THE PLATELET-LYMPHOCYTE RATIO COMPARED WITH PNEUMONIA SEVERITY INDEX IN THE PREDICTION OF COMMUNITY-ACQUIRED PNEUMONIA

Year 2018, Volume: 32 Issue: 3, 191 - 200, 15.12.2018

Mustafa Bolatkale

https://doi.org/10.5505/deutfd.2018.82584

Cited By: 1

Abstract

Objective:
Community-acquired
pneumonia (CAP) is a frequent cause of hospitalization and a leading cause of
mortality worldwide. The pneumonia severity index (PSI) is a clinical
prediction score for determining short-term mortality and morbidity in patients
with community-acquired pneumonia. The usefulness of rapid biochemical tests in
predicting the severity of pneumonia have been investigated.
Platelet-lymphocyte ratio (PLR) have been proposed as indicators of systemic
inflammation and infection. The aim of this study was to investigate the
predictive value of PLR levels and its association with PSI in patients with CAP in the emergency department.

Material and Method: This
prospective case-control study included 78 patients admitted with CAP and 78
control patients. The PLR mean levels were compared between the study and
control group. PSI were calculated and C-reactive protein (CRP) were measured.
Correlation analyses were performed to investigate the association of PLR
levels with CRP, PSI and hospitalization.

Results:  PLR levels were significantly higher in the
study group compared to the control group (p <0.001).The PLR level of 140,5
had sensitivity of 70.5% and specificity of 82.1% and was positively correlated
with PSI, CRP and hospitalization (r = 0.333; p= 0.003, r = 0.478; p <0.001,
r=0.386; p<0.001). PLR levels were significantly higher in the inpatients
subgroup compared to the outpatients subgroup (p= 0,001).

Conclusion: PLR levels
significantly increased and positively correlated with PSI, CRP and
hospitalization in adult patients presenting with CAP. PLR may be considered as
a predictive biomarker of CAP.

Keywords

Pneumonia severity index, platelet-lymphocyte ratio, C-reactive protein, community acquired pneumonia

Toplumda gelişen pnömoninin öngörülmesinde trombosit-lenfosit oranı ve pnömoni ağırlık skorunun karşılaştırılması

Abstract

Amaç: Toplumda
gelişen pnömoni (TGP), hastaneye yatışın sık nedenidir ve dünya çapında önde
gelen ölüm nedenidir. Pnömoni ağırlık skoru (PAS), TGP hastalarında kısa süreli
mortaliteyi ve morbiditeyi belirlemek için kullanılan bir klinik tahmin
skorudur. Pnömoni ağırlığını belirlemek için hızlı biyokimyasal tetkiklere
yönelik çalışmalar yapılmaktadır. Trombosit-lenfosit oranı (TLO) sistemik
inflamasyon ve enfeksiyonun göstergesi olarak önerilmiştir. Bu çalışmanın amacı
acil serviste TGP'li hastalarda TLO düzeylerinin prediktif değerini ve PAS ile
ilişkisini araştırmaktır.

Gereç ve Yöntem: Bu
prospektif vaka kontrol çalışmasında 78 TGP ile başvuran hasta ve 78 kontrol
olgusu yer almıştır. Ortalama TLO düzeyleri çalışma ve kontrol grubu arasında
karşılaştırıldı. PAS'ları hesaplandı ve C-reaktif protein düzeyleri (CRP)
ölçüldü. TLO düzeylerinin CRP, PAS ve hastaneye yatış ile ilişkisini araştırmak
için korelasyon analizleri yapıldı.

Bulgular: Çalışma
grubunda TLO düzeyleri kontrol grubuna göre anlamlı yüksekti (p <0,001). TLO
düzeyi 140,5 için %70.5 duyarlılık ve %82.1 özgüllük saptandı. PAS, CRP ve
hastaneye yatış ile pozitif korelasyon gösterdi (r = 0,333; p= 0,003, r =
0,478; p <0,001, r=0,386; p<0,001). TLO düzeyleri yatış verilen hasta alt
grubunda ayaktan tedavi edilen alt grupla karşılaştırıldığında istatistiksel
olarak yüksekti (p= 0,001).

Sonuç: TGP
ile başvuran erişkin hastalarda kan TLO düzeyleri anlamlı olarak artmış ve PAS,
CRP ve hastaneye yatış ile pozitif korelasyon göstermiştir. TLO, TGP hastalığı
için prediktif bir biyobelirteç olarak düşünülebilir.

Keywords

Pnömoni ağırlık skoru, trombosit-lenfosit oranı, C-reaktif protein, toplumda gelişen pnömoni

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