Abstract
Asinik hücreli karsinom (AHK) nadir görülen, yavaş büyüme hızına sahip, düşük dereceli malign tükürük bezi neoplazisidir. Tümör en sık parotiste saptanmakta olup minör tükürük bezi yerleşimi nadirdir. Tükürük bezinin neoplastik ve nonneoplastik lezyonlarında psammom cismi varlığı nadirdir. Burada maksiller sinüs yerleşimli, psammom cisimlerinden zengin, AHK olgusu ayırıcı tanıları ile birlikte sunulmaktadır. 59 yaşında erkek hasta bir yıldır devam eden burun tıkanıklığı şikayeti ile hastanemize başvurdu. Hastanın radyolojik görüntülemelerinde maksiller sinüsde, komşu kemik yapılarda ekspansiyona neden olan kitlesel bir lezyon görüldü. Maksillektomi materyalinde makroskopik olarak 6 cm çapındaki tümör izlendi. Tümörden hazırlanan kesitlerde, arada psammom cismi özelliğinde mikrokalsifikasyonlar içeren, asinüs benzeri yapılar izlendi. Tümör hücreleri bazofilik granuler sitoplazmalı, yuvarlak oval nukleuslu idi. Tümör hücreleri PAS ve dPAS ile sitoplazmik granuler tarzda boyandı. Olgu psammom cisimlerinden zengin AHK olarak raporlandı.
Keywords
References
- Simpson RHV, Chiosea S, Katabi N, Leivo I, Vielh P, Williams MD. World Health Organization classification of head and neck tumours. In: Acinic cell carcinoma. El-Naggar AE, Chan JKC, Grandis JR, Takata T, Slootweg PJ. (eds). Lyon: IARC; 2017. p. 166.
- Negahban S, Daneshbod Y, Khademi B, Seif I. Papillary cystic acinic cell carcinoma with many psammom bodies, so-called psammoma body-rich papillary cystic acinic cell carcinoma: report of a case with fine needle aspiration findings. Acta Cytol. 2009; 53: 440-4.
- Ali SZ. Acinic-cell carcinoma, papillary cystic variant: a diagnostic dilemma in salivary gland aspiration. Diagn Cytopathol. 2002;27:244-50.
- Das DK. Psammoma body: a product af dystrophic calcification or of a biologically active process that aims at limiting the growth and spread of tumor? Diagn Cytopathol. 2009;37:534-41.
- Frierson HF, Fechner RE. Chronic sialadenitis with psammoma bodies mimicking neoplasia in a Fine needle aspiration specimen from the submandibular gland. Am J Clin Pathol. 1991;95:884-8.
- Bottles K, Lowhagen T. Psammoma bodies in the aspiration cytology smears of an acinic-cell tumor. Acta Cytol. 1985;29:191-2.
- Whitlatch SP. Psammoma bodies in fine-needle aspiration biopsies of acinic cell tumor. Diagn Cytopathol. 1986;2:268-9.
- Zhang XP, Jiang GY, Zhang QF, Xu HT, Li QC, Wang EH. Primary acinic cell carcinoma of the lung with psammoma bodies: A case report and review of literature. Pathol Res Pract. 2017;213: 405-9.
- Seethala RR, Stenman G. Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Tumors of the Salivary Gland. Head Neck Pathol. 2017;11: 55-67.
- Drut R, Giménez PO. Acinic cell carcinoma of salivary gland with massive deposits of globular amyloid. Int J Surg Pathol. 2008;16:202-7.
Abstract
Acinic cell carcinoma (ACC) is a rarely seen, slowly growing, low-grade malignant neoplasia of the salivary gland. ACC is most frequently detected in the parotid gland, rarely it is localized in a minor salivary gland. Rarely psammoma bodies are seen in neoplasic, and nonneoplasic lesions of the salivary gland. Herein a case with psammoma body-rich ACC is presented together with its differential diagnosis. A 59-year-old male patient consulted our hospital with complaint of stuffy nose persisting for a year. His radiological examination revealed the presence of a mass lesion in the maxillary sinus which expanded neighbouring bony structures. Macroscopically a tumoral mass with a diameter of 6 cm was observed in maxillectomy specimen in sections prepared from the tumor, acini-like structures containing microcalcifications were observed. Tumor cells had basophilic granular cytoplasm, and round or oval shaped nuclei. Tumor cells stained with PAS and dPAS demonstrated cytoplasmic granules. The case was reported as “psammoma body-rich ACC”.
Keywords
References
- Simpson RHV, Chiosea S, Katabi N, Leivo I, Vielh P, Williams MD. World Health Organization classification of head and neck tumours. In: Acinic cell carcinoma. El-Naggar AE, Chan JKC, Grandis JR, Takata T, Slootweg PJ. (eds). Lyon: IARC; 2017. p. 166.
- Negahban S, Daneshbod Y, Khademi B, Seif I. Papillary cystic acinic cell carcinoma with many psammom bodies, so-called psammoma body-rich papillary cystic acinic cell carcinoma: report of a case with fine needle aspiration findings. Acta Cytol. 2009; 53: 440-4.
- Ali SZ. Acinic-cell carcinoma, papillary cystic variant: a diagnostic dilemma in salivary gland aspiration. Diagn Cytopathol. 2002;27:244-50.
- Das DK. Psammoma body: a product af dystrophic calcification or of a biologically active process that aims at limiting the growth and spread of tumor? Diagn Cytopathol. 2009;37:534-41.
- Frierson HF, Fechner RE. Chronic sialadenitis with psammoma bodies mimicking neoplasia in a Fine needle aspiration specimen from the submandibular gland. Am J Clin Pathol. 1991;95:884-8.
- Bottles K, Lowhagen T. Psammoma bodies in the aspiration cytology smears of an acinic-cell tumor. Acta Cytol. 1985;29:191-2.
- Whitlatch SP. Psammoma bodies in fine-needle aspiration biopsies of acinic cell tumor. Diagn Cytopathol. 1986;2:268-9.
- Zhang XP, Jiang GY, Zhang QF, Xu HT, Li QC, Wang EH. Primary acinic cell carcinoma of the lung with psammoma bodies: A case report and review of literature. Pathol Res Pract. 2017;213: 405-9.
- Seethala RR, Stenman G. Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Tumors of the Salivary Gland. Head Neck Pathol. 2017;11: 55-67.
- Drut R, Giménez PO. Acinic cell carcinoma of salivary gland with massive deposits of globular amyloid. Int J Surg Pathol. 2008;16:202-7.
Details
| Primary Language | English |
|---|---|
| Subjects | Clinical Sciences |
| Journal Section | Case Studies |
| Authors | |
| Publication Date | August 31, 2020 |
| Submission Date | March 18, 2020 |
| Published in Issue | Year 2020 Volume: 34 Issue: 2 |