Prevalence of BRAF Mutation in Papillary Thyroid Cancer

Year 2016, Volume: 43 Issue: 4, 569 - 575, 25.12.2016

Shatha Dmour Ala’a Al - Maaitah Tunc Eren Ozgur Ekinci Orhan Alimoglu

https://doi.org/10.5798/diclemedj.0921.2015.01.0521

Abstract

Objectives: Papillary thyroid cancer (PTC) is the most
common endocrine malignancy and the most common genetic anomaly with
PTC is the BRAF V600E mutation. This mutation is linked to many clinical
and pathological features and may have a diagnostic and therapeutic
role especially in the era of targeted therapy. The aim of this study is
to review the prevalence of BRAF V600E mutation in PTC, its
distribution according to the histological subtype and geographic area
and its association with the age of patients, gender, subtype and
recurrence of tumors.

Methods: The Pubmed database was searched to look for
articles about BRAF mutation in PTC. Outcomes of interest included
prevalence, age, gender, country, subtype and recurrence.

Results: The prevalence of BRAF V600E mutation in PTC
was 47%, with noticeably higher prevalence in the eastern countries. The
prevalence of BRAF V600E was also higher in the tall and classic
subtypes and could be associated with worse prognosis and higher risk of
recurrence.

Conclusions: The BRAF mutation, which is more prevalent in the eastern countries, is determined to be an important molecular marker for PTC.

Keywords

Papillary thyroid cancer, BRAF mutation

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