Research Article
Year 2019,
Volume: 46 Issue: 2, 201 - 207, 11.06.2019
Abstract
Amaç: Helikobakter pilori pozitifliği, ülkemizde ve dünyada
yüksek prevalansa sahip olup kronik gastrit, peptik ülser, mukoza ile ilişkili
lenfoid doku lenfoması ve gastrik adenokarsinomla ilişkili bulunmuştur.
Helikobakter pilori pozitifliği, yaygın olarak görülmesi ve geniş bir patolojik
spektrumu olması nedeniyle halk sağlığı açısından önemlidir. Çalışmamızda
nötrofil lenfosit oranı ve ortalama trombosit hacmi ile helikobakter pilori
pozitifliği arasındaki ilişkiyi göstermeyi amaçladık.
Yöntemler: Çalışmaya dispeptik şikâyetleri olan hastalardan
dışkıda HP direkt antijen testi sonucuna göre HP pozitifliği saptanan 73 olgu
ve helikobakter pilori negatif olan 77 olgu çalışmaya alındı. Olgular
helikobakter pilori pozitif ve negatif olarak iki gruba ayrıldı. Gruplar
arasında laboratuvar parametreleri karşılaştırıldı.
Bulgular: Helikobakter pilori pozitif ve helikobakter pilori
negatif hasta grupları arasında yaş ortalaması ve cinsiyet arasında anlamlı
farklılık yoktu (sırasıyla p=0,26, p=0.621). Helikobakter pilori enfeksiyonu
tespit edilen hastalarda kandaki nötrofil sayısında artma (p=0,001) ve lenfosit
sayısında azalma (p=0,006) ile birlikte nötrofil lenfosit oranındaki belirgin
artış istatistiksel olarak anlamlıydı (p=0,001). Helikobakter pilori negatif
hasta grubuna göre helikobakter pilori pozitif hastalarda C-reaktif protein
düzeyleri anlamlı olarak yüksek (p=0,011) ve negatif akut faz reaktanı olarak
bilinen albümin anlamlı derecede düşüktü (p=0,014). Eritrosit sedimantasyon
hızı ve ferritin düzeyleri helikobakter pilori pozitif hasta grubunda daha
yüksekti ancak iki grup arasında istatistiksel olarak anlamlı fark yoktu. Her
iki grup arasında ortalama trombosit hacmi düzeyleri yönünden anlamlı fark
bulunamadı (p=0,477).
Sonuç: Çalışmamızda helikobakter pilori pozitif hastalarda
ortalama trombosit hacimlerinde anlamlı bir farklılık görülmezken bu hastalarda
artmış nötrofil lenfosit oranı tespit ettik. Dispeptik yakınmalarla gelen
hastalarda yüksek nötrofil lenfosit oranı helikobakter pilori pozitifliği için
bir belirteç olabilir.
References
- 1. Huang Y, Wang QL, Cheng DD, et all. Adhesion and Invasion of Gastric Mucosa Epithelial Cells by Helicobacter pylori. Front Cell Infect Microbiol. 2016; 22; 6: 159.
- 2. Zhang M, Zhou YZ, Li XY, et all. Seroepidemiology of Helicobacter pylori infection in elderly people in the Beijing region, China. World J Gastroenterol. 2014; 20: 3635-9.
- 3. Simard J C, Cesaro A, Chapeton-Montes J, et all. S100A8 and S100A9 induce cytokine expression and regulate the NLRP3 inflammasome via ROS-dependent activation of NF-κB1. PloS One, 2013; 19: 8-8.
- 4. Wang F, Meng W, Wang B, et all. Helicobacter pylori-induced gastric inflammation and gastric cancer. Cancer Lett. 2014; 345: 196-202.
- 5. Dalla Nora M, Hörner R, De Carli DM, et all. Is The Immunocromatograpic Fecal antigen Test Effective For Primary Diagnosis of Helicobacter Pylori Infection in Dyspeptic Patients? Arg Gastroenterol. 2016; 53: 224-7.
- 6. Yu H, Lee H, Herrmann A, et all. Revisiting STAT3 signalling in cancer: new and unexpected biological functions. Nat Rev Cancer 2014; 14: 736-46.
- 7. Nakagawa H, Tamura T, Mitsuda Y, et all. Significant association between serum interleukin-6 and Helicobacter pylori antibody levels among H. pylori-positive Japanese adults. Mediators Inflamm. 2013; 2013: 142358-5.
- 8. Jia Y, Qu B, Wang B, et all. Effects of Active and Latent H. Pylori Infection Coupled With Chronic Alcohol Ingestion on Cytokine Profiles and Markers of Oxidative Balance in Men Seropositive For H. Pylori CagA Ab: An Observational Study. Medicine (Baltimore). 2018; 97: 34.
- 9. Farah R, Hamza H, Khamisy-Farah R. A link between platelet to lymphocyte ratio and Helicobacter pylori infection. J Clin Lab Anal. 2018; 32: 1.
- 10. Patel A, Laffan MA, Waheed U, et all. Randomised trials of human albumin for adults with sepsis: Systematic review and meta-analysis with trial sequential analysis of all-cause mortality. BMJ. 2014; 22: 349-4561.
- 11. Ates I, Bulut M, Ozkayar N, et all. Association between high platelet indices and proteinuria in patients with hypertension. Ann Lab Med. 2015; 35: 630–4.
- 12. Matowicka J, Karna J. Markers of inflammation, activation of blood platelets and coagulation disorders in inflammatory bowel diseases. Postepy Hig Med Dosw. 2016; 70: 305-12.
- 13. Shah B, Sha D, Xie D, et all. The relationship between diabetes, metabolic syndrome, and platelet activity as measured by mean platelet volume: the National Health and Nutrition Examination Survey, 1999-2004. Diabetes Care. 2012; 35: 1074–1078.
- 14. Umit H, Umit EG. Helicobacter pylori and mean platelet volume: a relation way before ımmune thrombocytopenia? Eur Rev Med Pharmacol Sci. 2015; 19: 2818-23.
- 15. Güçlü M, Agan F. Association of Severity of Helicobacter pylori Infection with Peripheral Blood Neutrophil to Lymphocyte Ratio and Mean Platelet Volume. Euroasian J Hepatogastroenterol. 2017; 7: 11–16.
- 16. Topal F, Karaman K, Akbulut S, et all. The relationship between mean platelet volume levels and the inflammation in Helicobacter pylori gastritis. J Natl Med Assoc. 2010; 102: 726-30.
- 17. Farah R, Khamisy-Farah R. Association of neutrophil to lymphocyte ratio with presence and severity of gastritis due to Helicobacter pylori infection. J Clin Lab Anal. 2014; 28: 219–23.
- 18. Jafarzadeh A, Akbarpoor V, Nabizadeh M, et all. Total leukocyte counts and neutrophil-lymphocyte count ratios among Helicobacter pylori-infected patients with peptic ulcers: independent of bacterial CagA status. Southeast Asian J Trop Med Public Health. 2013; 44: 82–88.
- 19. Chen L, Xu W, Lee A, et all. The impact of Helicobacter pylori infection, eradication therapy and probiotic supplementation on gut microenvironment homeostasis: An open-label, randomized clinical trial. EBioMedicine 2018; 35: 87-96.
- 20. Westerik N, Reid G, Sybesma W, et all. The Probiotic Lactobacillus rhamnosus for Alleviation of Helicobacter pylori-Associated Gastric Pathology in East Africa. Front Microbiol. 2018; 14: 9-1873.
Year 2019,
Volume: 46 Issue: 2, 201 - 207, 11.06.2019
Abstract
References
- 1. Huang Y, Wang QL, Cheng DD, et all. Adhesion and Invasion of Gastric Mucosa Epithelial Cells by Helicobacter pylori. Front Cell Infect Microbiol. 2016; 22; 6: 159.
- 2. Zhang M, Zhou YZ, Li XY, et all. Seroepidemiology of Helicobacter pylori infection in elderly people in the Beijing region, China. World J Gastroenterol. 2014; 20: 3635-9.
- 3. Simard J C, Cesaro A, Chapeton-Montes J, et all. S100A8 and S100A9 induce cytokine expression and regulate the NLRP3 inflammasome via ROS-dependent activation of NF-κB1. PloS One, 2013; 19: 8-8.
- 4. Wang F, Meng W, Wang B, et all. Helicobacter pylori-induced gastric inflammation and gastric cancer. Cancer Lett. 2014; 345: 196-202.
- 5. Dalla Nora M, Hörner R, De Carli DM, et all. Is The Immunocromatograpic Fecal antigen Test Effective For Primary Diagnosis of Helicobacter Pylori Infection in Dyspeptic Patients? Arg Gastroenterol. 2016; 53: 224-7.
- 6. Yu H, Lee H, Herrmann A, et all. Revisiting STAT3 signalling in cancer: new and unexpected biological functions. Nat Rev Cancer 2014; 14: 736-46.
- 7. Nakagawa H, Tamura T, Mitsuda Y, et all. Significant association between serum interleukin-6 and Helicobacter pylori antibody levels among H. pylori-positive Japanese adults. Mediators Inflamm. 2013; 2013: 142358-5.
- 8. Jia Y, Qu B, Wang B, et all. Effects of Active and Latent H. Pylori Infection Coupled With Chronic Alcohol Ingestion on Cytokine Profiles and Markers of Oxidative Balance in Men Seropositive For H. Pylori CagA Ab: An Observational Study. Medicine (Baltimore). 2018; 97: 34.
- 9. Farah R, Hamza H, Khamisy-Farah R. A link between platelet to lymphocyte ratio and Helicobacter pylori infection. J Clin Lab Anal. 2018; 32: 1.
- 10. Patel A, Laffan MA, Waheed U, et all. Randomised trials of human albumin for adults with sepsis: Systematic review and meta-analysis with trial sequential analysis of all-cause mortality. BMJ. 2014; 22: 349-4561.
- 11. Ates I, Bulut M, Ozkayar N, et all. Association between high platelet indices and proteinuria in patients with hypertension. Ann Lab Med. 2015; 35: 630–4.
- 12. Matowicka J, Karna J. Markers of inflammation, activation of blood platelets and coagulation disorders in inflammatory bowel diseases. Postepy Hig Med Dosw. 2016; 70: 305-12.
- 13. Shah B, Sha D, Xie D, et all. The relationship between diabetes, metabolic syndrome, and platelet activity as measured by mean platelet volume: the National Health and Nutrition Examination Survey, 1999-2004. Diabetes Care. 2012; 35: 1074–1078.
- 14. Umit H, Umit EG. Helicobacter pylori and mean platelet volume: a relation way before ımmune thrombocytopenia? Eur Rev Med Pharmacol Sci. 2015; 19: 2818-23.
- 15. Güçlü M, Agan F. Association of Severity of Helicobacter pylori Infection with Peripheral Blood Neutrophil to Lymphocyte Ratio and Mean Platelet Volume. Euroasian J Hepatogastroenterol. 2017; 7: 11–16.
- 16. Topal F, Karaman K, Akbulut S, et all. The relationship between mean platelet volume levels and the inflammation in Helicobacter pylori gastritis. J Natl Med Assoc. 2010; 102: 726-30.
- 17. Farah R, Khamisy-Farah R. Association of neutrophil to lymphocyte ratio with presence and severity of gastritis due to Helicobacter pylori infection. J Clin Lab Anal. 2014; 28: 219–23.
- 18. Jafarzadeh A, Akbarpoor V, Nabizadeh M, et all. Total leukocyte counts and neutrophil-lymphocyte count ratios among Helicobacter pylori-infected patients with peptic ulcers: independent of bacterial CagA status. Southeast Asian J Trop Med Public Health. 2013; 44: 82–88.
- 19. Chen L, Xu W, Lee A, et all. The impact of Helicobacter pylori infection, eradication therapy and probiotic supplementation on gut microenvironment homeostasis: An open-label, randomized clinical trial. EBioMedicine 2018; 35: 87-96.
- 20. Westerik N, Reid G, Sybesma W, et all. The Probiotic Lactobacillus rhamnosus for Alleviation of Helicobacter pylori-Associated Gastric Pathology in East Africa. Front Microbiol. 2018; 14: 9-1873.
There are 20 citations in total.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Research Article |
| Authors | |
| Publication Date | June 11, 2019 |
| Submission Date | November 5, 2018 |
| Published in Issue | Year 2019 Volume: 46 Issue: 2 |