The Evaluation of SCUBE-1 and sCD40L Levels in Diabetic Nephropathy

Year 2019, Volume: 21 Issue: 3, 243 - 247, 30.12.2019

Hilal Karakaş Mehmet Ali Eren , İsmail Koyuncu , İdris Kırhan , Tevfik Sabuncu

https://doi.org/10.18678/dtfd.638343

Cited By: 1

Abstract

Aim: There is a close link between diabetic nephropathy and atherosclerotic heart disease. We aimed to evaluate the changes of SCUBE-1 and sCD40L, which play role in the course of atherosclerosis, with the progression of nephropathy in patients with type 2 diabetes.

Material and Methods: Thirty healthy subjects (group 1) and 74 patients with type 2 diabetes (divided into 3 groups as normal albuminuria group (group 2, n=33), moderately increased albuminuria group (group 3, n=22) and severely increased albuminuria group (group 4, n=19)) were enrolled in the study. Plasma SCUBE-1 and sCD40L levels were measured using the enzyme-linked immunosorbent assay technique.

Results: Mean SCUBE-1 levels were significantly higher in group 4 compared to group 1 and group 2 (p=0.005 and p=0.014, respectively) and in group 3 compared to group 1 and group 2 (p=0.011 and p=0.028, respectively). Mean sCD40L levels were significantly higher in group 4 than in other three groups (all p<0.001), and in group 3 than in group 1 and group 2 (p=0.001 and p=0.016, respectively). Furthermore, SCUBE-1 level was positively correlated with total cholesterol level (r=0.212, p=0.031) and triglyceride (r=0.194, p=0.049). Likewise, sCD40L level was positively correlated with only creatinine level (r=0.297, p=0.002).

Conclusion: SCUBE-1 and sCD40L levels increased with the progression of nephropathy in type 2 diabetes. This increment suggested that SCUBE-1 and sCD40L may play key role in the course of atherosclerosis due to diabetic nephropathy and, diabetic nephropathy may affect the levels of these parameters.

Keywords

SCUBE-1, sCD40L, atherosclerosis, diabetic nephropathy

Supporting Institution

Harran University Scientific Research Coordination Board

Project Number

17020

Diyabetik Nefropatide SCUBE-1 ve sCD40L Seviyelerinin İncelenmesi

Abstract

Amaç: Diyabetik nefropati ve aterosklerorik kalp hastalıkları arasında yakın bir ilişki mevcuttur. Biz de, ateroskleroz sürecinde rol oynadığı bilinen SCUBE-1 ve sCD40L’ın tip 2 diyabeti olan hastalarda, nefropatinin ilerlemesi ile birlikte nasıl değiştiğini araştırmayı amaçladık.

Gereç ve Yöntemler: Otuz sağlıklı kişi (grup 1) ve 74 tip 2 diyabeti olan hasta (normal albuminüri grubu (grup 2, n=33), orta derece artmış albuminüri grubu (grup 3, n=22) ve şiddetli derecede artmış albuminüri grubu (grup 4, n=19) olarak üç gruba ayrıldı) çalışmaya dahil edildi. Plazma SCUBE-1 ve sCD40L seviyeleri, enzim-bağlı immunosorbent analiz tekniği kullanılarak ölçüldü.

Bulgular: Ortalama SCUBE-1 seviyeleri grup 1 ve grup 2 ile karşılaştırıldığında, grup 4’te (sırasıyla p=0,005 ve p=0,014) ve grup 1 ve grup 2 ile karşılaştırıldığında grup 3’te (sırasıyla p=0,011 ve p=0,028) anlamlı olarak yüksekti. Ortalama sCD40L seviyeleri grup 4’te diğer üç gruptan (tüm p<0,001) ve grup 3’te ise grup 1 ve grup 2’den (sırasıyla p=0,001 ve p=0,016) anlamlı olarak yüksekti. Ayrıca SCUBE-1 seviyeleri total kolesterol seviyesi (r=0,220; p=0,025) ve trigliserit (r=0,194; p=0,049) ile pozitif yönlü koreleydi. Yanı sıra, sCD40L seviyesi ise sadece kreatinin seviyesi (r=0,297; p=0,002) ile pozitif yönlü koreleydi.

Sonuç: SCUBE-1 ve sCD40L seviyeleri tip 2 diyabette nefropatinin progresyonu ile artmaktadır. Bu artış SCUBE-1 ve sCD40L’ın diyabetik nefropatiye bağlı ateroskleroz sürecinde anahtar rol oynuyor olabileceğini ve diyabetik nefropatinin bu parametrelerin seviyelerini etkiliyor olabileceğini düşündürmektedir.

Keywords

SCUBE-1, sCD40L, ateroskleroz, diyabetik nefropati

Project Number

17020

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