Fibrinojen/Albümin Oranının COVID-19 Hastalarının Prognozundaki Değeri

Year 2022, Volume: 24 Issue: 2, 176 - 181, 30.08.2022

Esen Çiçekli , Saadet Sayan , Elif Sarıca Darol , Dilcan Kotan

https://doi.org/10.18678/dtfd.1108086

Cited By: 2

Abstract

Amaç: Fibrinojen ve albümin inflamasyonda rol oynayabilen proteinlerdendir. Bu çalışmada, koronavirüs hastalığı 2019 (coronavirus disease 2019, COVID-19) hastalarında fibrinojen, albümin ve fibrinojen/albümin oranı (FAR) düzeylerinin hastalık şiddeti ve prognoz belirteçleri olarak rolünün araştırılması amaçlanmıştır.
Gereç ve Yöntemler: Çalışmada Mart ve Mayıs 2020 tarihleri arasında COVID-19 tanısı ile Sakarya Eğitim ve Araştırma Hastanesi Nöroloji Kliniği’ne yatırılan 19 ve 84 yaş arasındaki 71 hasta geriye dönük olarak analiz edildi. Hastaların fibrinojen, albümin, FAR, D-dimer, trombosit ve C-reaktif protein (CRP) düzeyleri, hastanede kalış süresinin uzunluğu, hayatta kalma ve COVID-19 klinik şiddetine göre karşılaştırıldı.
Bulgular: Hastaların 28’i (%39,4) erkek ve 43’ü (%60,6) kadın olup yaş ortalaması 55,7±20,7 yıl idi. COVID-19 klinik şiddetine göre ayrılmış olan gruplar arasında yaş, fibrinojen, albümin, FAR, D-dimer ve CRP değerleri açısından anlamlı bir farklılık vardı (tüm p değerleri <0,001). Ayrıca, hastanede daha uzun süre yatan hastalarda fibrinojen, FAR, D-dimer ve CRP değerleri anlamlı olarak daha yüksek bulunurken, bu hastalarda albümin düzeyleri daha düşüktü (tüm p değerleri <0,001). Hayatta kalamayan hastalarda yaşayan hastalara göre FAR değerleri daha yüksek ve albümin değerleri daha düşüktü (sırasıyla, p=0.025 ve p<0.001).
Sonuç: FAR seviyeleri, COVID-19 hastalarında ölüm riskini tahmin etmede faydalı olabilir. Ayrıca hastalığın şiddeti ve hastanede kalış süresi arttıkça daha yüksek seviyelere sahip olduğu için prognozu belirlemede de yardımcı ve faydalı olabilir.

Keywords

COVID-19, fibrinojen, albumin, fibrinojen/albumin

The Value of Fibrinogen/Albumin Ratio on Prognosis of COVID-19 Patients

Abstract

Aim: Fibrinogen and albumin are proteins that play a role in inflammation. In this study, it was aimed to investigate the role of fibrinogen, albumin, and fibrinogen/albumin ratio (FAR) levels as markers of disease severity and prognosis in coronavirus disease 2019 (COVID-19) patients.
Material and Methods: Seventy-one patients aged between 19 and 84 years diagnosed with COVID-19 who were hospitalized in Sakarya University Training and Research Hospital, Neurology Department between March and May 2020 were analyzed retrospectively. Fibrinogen, albumin, FAR, D-dimer, platelet, and C-reactive protein (CRP) levels of the patients were compared according to the length of hospitalization duration, survival, and clinical severity of COVID-19.
Results: Twenty-eight (%39.4) of the patients were male and 43 (%60.6) were female, and the mean age was 55.7±20.7 years. There was a significant difference between the groups of COVID-19 clinical severity in terms of age, fibrinogen, albumin, FAR, D-dimer, and CRP values (all p values were <0.001). Also, significantly higher fibrinogen, FAR, D-dimer, and CRP values were found in patients hospitalized longer, while the albumin level was lower in these patients (all p values were <0.001). FAR values were higher and albumin values were lower in non-surviving patients compared to surviving patients (p=0.025 and p<0.001, respectively).
Conclusion: FAR levels may be useful in predicting mortality risk in COVID-19 patients. In addition, it may be helpful and useful in determining the prognosis since it has higher levels as the severity of the disease and the length of hospital stay increase.

Keywords

fibrinogen, albumin, fibrinogen/albumin ratio, COVID-19

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