Pediatrik Non-Skatrisyel Alopesilerde Vitamin D ve Hematolojik Parametrelerin Değerlendirilmesi

Year 2025, Issue: Early Access

Betül Şereflican , Merve Dilcan , Mualla Polat

https://doi.org/10.18678/dtfd.1579685

Abstract

Amaç: D vitamini saç folikülü döngüsü için önemli bir faktördür. Alopesi areata (AA), androgenetik alopesi (AGA) ve telogen effluvium (TE) skarsız alopesilerin en sık görülen formlarıdır. Bu çalışmada non-skatrisyel alopesisi olan çocuk ve adölesanlarda D vitamini düzeylerinin ve hemogram parametrelerininin belirlenmesi amaçlanmıştır.
Gereç ve Yöntemler: Bu geriye dönük çalışmaya AA, AGA ve TE tanısı almış ve 18 yaş altı olan toplam 157 hasta dahil edildi. D vitamini düzeyleri ile nötrofil/lenfosit (neu/lym) ve platelet/lenfosit (plt/lym) oranları değerlendirildi. D vitamini düzeyleri başvuru dönemine göre sonbahar, kış, ilkbahar ve yaz olmak üzere dört farklı grupta incelendi.
Bulgular: Tüm hastaların 30'u AA, 11'i AGA ve 116'sı TE tanısı aldı. D vitamini düzeylerine bakılmış olan 153 hastanın 128'inde D vitamini eksikliği, 20'sinde yetersizlik, 5'inde ise yeterlilik saptandı. Gruplar arasında D vitamini düzeyleri açısından istatistiksel olarak anlamlı bir farklılık yoktu (p=0,114). Ayrıca, gruplar arasında D vitamini eksikliği ve yetersizliği açısından da istatistiksel olarak anlamlı bir fark bulunmadı (p=0,403). D vitamini düzeyleri erkeklerde kadınlara göre (p<0,001) ve sonbaharda kışa göre (p=0,043) anlamlı olarak daha yüksekti. Neu/lym oranı, TE hastalarında AA grubundaki hastalara göre anlamlı olarak daha yüksekti (p=0,005).
Sonuç: Tüm non-skatrisyel alopesilerin çok yüksek bir yüzdesinde D vitamini eksikliği görüldü. Neu/lym oranı TE'li hastalar için diğer non-skatrisyel alopesilerden daha uygun bir inflamatuar belirteç olabilir.

Keywords

Alopesi, alopesi areata, androgenetik alopesi, D vitamini

Evaluation of Vitamin D and Hematological Parameters in Pediatric Non-Scarring Alopecias

Abstract

Aim: Vitamin D is an important factor for the hair follicle cycle. Alopecia areata (AA), androgenetic alopecia (AGA), and telogen effluvium (TE) are the most common forms of non-scarring alopecia. This study aimed to define vitamin D levels and hemogram parameters in children and adolescents with non-cicatricial alopecia.
Material and Methods: A total of 157 patients under the age of 18 and diagnosed with AA, AGA, and TE were included in this retrospective study. Vitamin D levels, and neutrophil/lymphocyte (neu/lym) and platelet/lymphocyte (plt/lym) ratios were evaluated. Vitamin D levels were examined in four different groups according to the admission period as autumn, winter, spring, and summer.
Results: Of the patients, 30 were diagnosed with AA, 11 with AGA, and 116 with TE. Vitamin D deficiency was detected in 128 of 153 patients, of whom vitamin D levels were examined, insufficiency in 20, and sufficiency in 5. There was no statistically significant difference in vitamin D levels between groups (p=0.114). Also, no statistically significant difference was found between the groups in terms of vitamin D deficiency and insufficiency (p=0.403). Vitamin D levels were significantly higher in males than in females (p<0.001), and in autumn than in winter (p=0.043). The ratio of neu/lym in patients with TE was significantly higher than the patients in the AA group (p=0.005).
Conclusion: Vitamin D deficiency was seen in a very high percentage of all non-cicatricial alopecia. Neu/lym ratio may be a more appropriate inflammatory marker for patients with TE than the other nonscarring alopecia.

Keywords

Alopecia, alopecia areata, androgenetic alopecia, vitamin D

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