1-(4-Klorobenzil)-2-(piridin-2-yl) benzimidazol Biyoaktif Organik Bileşiğinin Sentezi ve Karakterizasyonu

Year 2023, Volume: 11 Issue: 2, 775 - 786, 30.04.2023

Meltem Oğuz , Ersin Orhan

https://doi.org/10.29130/dubited.1104207

Abstract

Bu çalışmada 1-(4-klorobenzil)-2-(piridin-2-yl)-1H-benzo[d]imidazol genel formülüne sahip organik bileşiği, 2- (2-piridil)benzimidazol’ün potasyum karbonat (K2CO3) ile reaksiyona sokulması ve ardından 4-klorobenzil klorür ile tepkimesi sonucu hazırlandı. Sentezlenen organik bileşik IR, UV-VIS, 1H, 13C NMR spektroskopisi ve ESI-MS spektroskopisi dahil standart tekniklerle karakterize edildi. Benzimidazol türevi bileşiğinin termal bozunma ölçüm verileri incelendi. Bu ölçümler termogravimetrik analiz (TGA) ve diferansiyel termal analiz
(DTA) teknikleri ile yapıldı ve floresans spektrum değerleri kaydedildi.

Keywords

Floresans, piridil benzimidazol, termal bozunma, biyolojik aktivite

Supporting Institution

Düzce Üniversitesi

Project Number

2022.05.03.1304

Thanks

Bu çalışma Düzce Üniversitesi Bilimsel Araştırma Projeleri tarafından desteklenmiştir (Proje no: 2022.05.03.1304).

Synthesis and Characterization of 1-(4-Chlorobenzyl)-2-(pyridine-2- yl)benzimidazole Bioactive Organic Compound

Abstract

In this study, the organic compound with the general formula 1-(4-chlorobenzyl)-2-(pyridin-2-yl)-1H- benzo[d]imidazole was reacted with 2-(2-pyridyl)benzimidazole with potassium carbonate (K2CO3). It was prepared subsequent reaction with 4-chlorobenzyl chloride. The synthesized organic compound was characterized by standard techniques including IR, UV-VIS, 1H, 13C NMR spectroscopy and ESI-MS spectroscopy. Thermal degradation measurement data of benzimidazole derivative compound were examined. These measurements were made with thermogravimetric analysis (TGA) and differential thermal analysis (DTA) techniques and fluorescence
Spectrum values were recorded.

Keywords

Fluorescence, pyridyl benzimidazole, thermal decomposition, biological activity

Project Number

2022.05.03.1304

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