Yeni Tiyazol Bazlı Tiyosemikarbazon Komplekslerinin Sentezi ve in vitro Biyolojik Değerlendirmeleri

Year 2024, Volume: 12 Issue: 3, 1389 - 1397, 31.07.2024

Dilek Nartop , Elvan Hasanoğlu Özkan , Hatice Öğütçü , Nurdan Kurnaz Yetim

https://doi.org/10.29130/dubited.1402771

Abstract

Sunulan bu çalışmada, yeni heterosiklik tiyazol bazlı tiyosemikarbazon Ag(I) kompleksleri (Hc1, Hc2, Hc3) template yöntem ile elde edildi. Sentezlenen tiyosemikarbazon bileşiklerinin yapıları bazı spektroskopik teknikler (element analizi, infrared spektra (IR), termogravimetrik analiz (TGA), organic elemental analiz, ve magnetik duyarlılık ölçümleri) ile karakterize edildi. Yeni heterosiklik tiyazol bazlı tiyosemikarbazon Ag(I) komplekslerinin biyolojik aktiviteleri potansiyel antimikrobiyal ajanlar olarak seçilmiş hastalık yapıcı patojenlere (Micrococcus luteus ATCC9341, Staphylococcus epidermidis ATCC12228, Bacillus cereus RSKK863, Pseudomonas aeroginosa ATCC27853, Klebsiella pneumonia ATCC27853, Enterobacter aerogenes ATCC51342, Salmonella typhi H NCTC9018394, Shigella dysenteria NCTC2966, Proteusv vulgaris RSKK96026, Candida albicans Y-1200-NIH) karşı in vitro olarak incelendi.

Keywords

Ag(I) kompleksi, Tiyazol, Tiyosemikarbazon, Biyolojik aktivite

Ethical Statement

Gerekli değil

Supporting Institution

Düzce University Scientific Project (Project no: 2021.05.03.1215)Üniversitesi

Thanks

Bu çalışma Düzce Üniversitesi Blilmsel Araştırma Projesi tarafondan desteklenmiştir (Project no: 2021.05.03.1215).

Synthesis and in vitro Biological Assessments of Novel Thiazole-Based Thiosemicarbazone Complexes

Abstract

In the present work, novel heterocyclic thiazole-based thiosemicarbazone Ag(I) complexes (Hc1, Hc2, Hc3) were obtained using the template method. The structures of synthesized thiosemicarbazone compounds were determined by some spectroscopic techniques (element analysis, infrared spectra (IR), thermogravimetric analysis (TGA), organic elemental analysis, and magnetic susceptibility measurements). The biological activities of novel heterocyclic thiazole-based thiosemicarbazone Ag(I) complexes werev screenedv in vitro against selected disease-causing pathogens (Micrococcus luteus ATCC9341, Staphylococcus epidermidis ATCC12228, Bacillus cereus RSKK863, Pseudomonas aeroginosa ATCC27853, Klebsiella pneumonia ATCC27853, Enterobacter aerogenes ATCC51342, Salmonellav typhi H NCTC9018394, Shigella dysenteria NCTC2966, Proteus vulgaris RSKK96026, Candidav albicans Y-1200-NIH) were as potential antimicrobial agents. It was determined that the thiazole-based thiosemicarbazone Ag(I) complexes exhibited high or moderate antibacterial and antifungal activity.

Keywords

Ag(I) complex, Thiazole, Thiosemicarbazone, Biological activity

Ethical Statement

Not necessary

Supporting Institution

Düzce University Scientific Project (Project no: 2021.05.03.1215).

Thanks

This work is supported by Düzce University Scientific Project (Project no: 2021.05.03.1215).

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