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Alıç Meyvesi ve Yaprağı (Crataegus Spp.): Hipertansiyona Karşı Tedavi Edici Potansiyeli Üzerine Bir İnceleme

Year 2024, Volume: 3 Issue: 2, 1 - 12, 28.12.2024

Pınar Karagül

Abstract

Hipertansiyon, küresel ölçekte en yaygın görülen kardiyovasküler rahatsızlıklardan biridir. Hipertansiyon tedavisinde kullanılan ilaçlarla ilgili yapılan bilimsel araştırmalar, birçok sentetik ilacın ciddi yan etkilere yol açabileceğini ortaya koymaktadır. Bu durum, doğal terapötik bileşiklerin araştırılmasına olan ilgiyi artırmıştır. Özellikle, insan beslenmesinde önemli yer tutan ve antik dönemlerden bu yana hastalıkların tedavisinde kullanılan yenilebilir ve tıbbi bitkiler, dikkat çeken bir çalışma alanı haline gelmiştir. Bu bitkiler, düşük yan etki profilleri ve geniş biyolojik etkileri nedeniyle günümüzde daha fazla araştırılmaktadır. Crataegus monogyna Jacq. (Alıç), Rosaceae ailesine ait önemli bir yenilebilir bitki olup geleneksel tıpta geniş bir kullanım alanına sahiptir. Yapılan çalışmalar, bu bitkinin içeriğindeki çeşitli biyoaktif doğal bileşikler sayesinde farklı fizyolojik ve farmakolojik etkiler sunduğunu ortaya koymuştur. Ayrıca, bilimsel veriler, alıcın toksisite riskinin oldukça düşük seviyelerde olduğunu desteklemektedir. Bu nedenle bu derlemede, alıç meyvesi ve yapraklarının biyoaktif bileşenleri ve bunların hipertansiyon üzerindeki olası etkileri bilimsel literatür ışığında ele alınmıştır.

Keywords

Alıç Hipertansiyon Crataegus monogyna

References

  • Bahorun, T., Trotin, F., Pommery, J., Vasseur, J. & Pinkas, M. (1994). Antioxidant activities of Crataegus monogyna extracts. Planta Med. 60(4), 323-328.
  • Bahorun T., Trotin F., Pommery J. et al. (1994). Inhibition of thromboxane A2 biosynthesis in vitro by the main components of Crataegus oxyacantha. Prostaglandins Leukotrienes Essential Fatty Acids (PLEFA), 50(4), 173-175.
  • Batinelli, L., Daniele, C., Cristiani, M., Bisignano, G., Laija, A. &Mazzanti, G. (2006). In vitro antifungal and anti-elastase activity of some aliphatic aldehydes from Olea europaea L. fruit. Phytomed. 13, 558-563.
  • Birman H., Tamer Ş., Melikoğlu G., & Meriçli A.H. (2015). Hypotensive Activity of Crataegus tanacetifolia. J. Fac. Pharm. Istanbul Univ. 34(2), 23-26.
  • Braun, L. & Cohen, M. (2015). Herbs and natural supplements, Volume 2: An evidence-based guide. Elsevier Health Sciences, p. 543-552, Saint Louis.
  • Brouwers, S. & Staessen, J.A. (2021). Arterial hypertension. The Lancet 398(10296), 249-261.
  • Chang, Q., Zuo, Z., Harrison, F. & Chow, M.S.S. (2002). Hawthorn. J. Clin. Pharmacol. 42, 605–612.
  • Chi, B., Zhang, M., Sun, L., Liu, H. & Tian, Z. (2024). Study on the hypotensive effect and mechanism of hawthorn (Crataegus pinnatifida) fruits and hyperoside in spontaneously hypertensive rats. Food Funct.15(10), 5627-5640.
  • Cicero, A.F. (2024). Food Supplementation With Diuripres for Blood Pressure Modulation in Subjects With High-Normal Blood Pressure (CONDOR), 2021-09-01, 60.
  • Cui, T., Li, J.Z., Kayahara, H., Ma, L., Wu, L.X. & Nakamura, K. (2006). Quantification of the polyphenols and triterpene acids in Chinese hawthorn fruit by high-performance liquid chromatography. J. Agric. Food Chem. 54, 4574–4581.
  • Hill, C. (2013). Nitric Oxide mediated vasodilatory response to Hawthorn standardized extract. University of North Carolina, 2010-05, 45.
  • Du, W., Fan, H.M., Zhang, Y.X., Jiang, X.H. & Li, Y. (2022). Effect of flavonoids in Hawthorn and Vitamin C prevents hypertension in rats induced by heat exposure. Molecules 27(3), 866.
  • Edwards, J.E., Brown, P.N., Talent, N., Dickinson, T.A. & Shipley, P.R. (2012). A review of the chemistry of the genus Crataegus. Phytochem. 79, 5–26.
  • European Society of Cardiology (ESC) (2024). "https://www.escardio.org/“, Erişim Tarihi: 25.12.2024.
  • European Society of Hypertension, (ESH) (2024). "https://www.eshonline.org/", Erişim Tarihi: 25.12.2024.
  • Fisher, C. (2009). Materia Medica of Western Herbs. Vitex Medica, Nelson, New Zealand.
  • Guo, R., Pittler, M.H. & Ernst, E. (2008). Hawthorn extract for treating chronic heart failure (Review). Cochrane Datab. Syst. Rev. (Online).
  • Guo, R., Pittler, M. H., Schmidt, K. & Ernst, E. (2003). Hawthorn extract for treating chronic heart failure: meta-analysis of randomized trials. Amer. J. Medic. 114(8), 665-674.
  • Graham, J. D. (1939). The Influence of Traditional Remedies on Cardiovascular Health. Journal of Ethnobotany, 12(4), 21
  • Holubarsch, C. J., Meinertz, W. S. C. T., Gaus, W., & Tendera, M. (2008). The efficacy and safety of Crataegus extract WS® 1442 in patients with heart failure: the SPICE trial. Eur. J. Heart Fail., 10(12), 1255-1263.
  • Jalali, A. S., Hasanzadeh, S., & Malekinejad, H. (2012). Crataegus monogyna aqueous extract ameliorates cyclophosphamide-induced toxicity in rat testis: stereological evidences. Acta Med Iran., 50(1), 1-8. PMID: 22267371.
  • Joey P. Granger (2006). An emerging role for inflammatory cytokines in hypertension , Am J Physiol Heart Circ Physiol, 290: 923–924.
  • J. Vibes, B. Lasserre, J. & Gleye, C. (1994). Declume, Inhibition of thromboxane A2 biosynthesis in vitro by the main components of Crataegus oxyacantha (Hawthorn) flower heads, Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 50(4), 173-175.
  • Kazemi, E., Mansoursamaei, A., Bijan, M., Hosseinzadeh, A., Namavar, H., Javedani Masroor, M., & Sheibani, H. (2024). Effect of Crataegus oxyacantha on high blood pressure: A randomized single-blind controlled trial. Advances in Integrative Medicine.
  • Koçyildiz, Z.C., Birman, H., Olgaç, V., Akgün-Dar, K., Melikoğlu, G. & Meriçli, A.H. (2006). Crataegus tanacetifolia leaf extract prevents L-NAME-induced hypertension in rats: a morphological study. Phytother Res. Jan; 20(1),66-70.
  • Lillian Barros, Carvalho, A. M., & Ferreira, I. C. F. R. (2011). Phytochem. Anal., 22, 181–188.
  • Martinelli, F., Perrone, A., Yousefi, S., et al. (2021). Botanical, Phytochemical, Anti-Microbial and Pharmaceutical Characteristics of Hawthorn (Crataegus monogyna Jacq.), Rosaceae. Molecules, 26, 7266.
  • Mark Houston, (2019). Effect of a Nitric Oxide Supplementation Product on Endothelial Dysfunction and Prehypertensive Adults, Hypertension Institute, 2017-04-05,42.
  • Alexander, M., Sarris, J. & Wardle, J. (Eds.) (2014). Hypertension and stroke, Clinical Naturopathy: An Evidence-Based Guide to Practice, Elsevier, Australia, Chatswood, NSW, Australia (2014), pp. 243-256
  • McEwen, B.J. (2015). The of herbal medicine on platelet function and coagulation: A narrative review, Semin. Thromb. Hemost. 41(3), 300-314.
  • Nabavi, S. F., Nabavi, S. M., & Moghaddam, A. H. et al. (2012). Protective effects of Allium paradoxum against gentamicin-induced nephrotoxicity in mice. Food Funct., 3, 28–29.
  • Nabavi, S. F., Nabavi, S. M., Setzer, W., & Nabavi, S. A., et al. (2014). İnsan miR-17–3p ekspresyonunun metil 3-O-metil gallat tarafından modüle edilmesi. Mol. Nutr. Food Res., 58, 1776–1784.
  • Nabavi, S. F., Habtemariam, S., Ahmed, T., Sureda, A., Daglia, M., Sobarzo-Sánchez, E., & Nabavi, S. M. (2015). Polyphenolic Composition of Crataegus monogyna Jacq.: From Chemistry to Medical Applications. Nutrients, 7(9), 7708-7728.
  • Ornelas-Lim, C., Luna-Vázquez, F.J., Rojas-Molina, A. & Ibarra-Alvarad, C. (2021). Development of a quantified herbal extract of hawthorn Crataegus mexicana leaves with vasodilator effect. Saudi Pharm J. Nov; 29(11), 1258-1266. doi: 10.1016/j.jsps.2021.10.002. Epub 2021 Oct 19. PMID: 34819787; PMCID: PMC8596289.
  • Pelliccia, F. (2013). Prehypertension and Dietary Supplements - The PYRAMIDS Study (PYRAMIDS), University of Johannesburg, 2014-10, 30.
  • Rigelsky, J.M, & Sweet, B.V. (2002). Hawthorn: Pharmacology and therapeutic uses. Am J Health Syst Pharm. 59, 417-422.
  • Sarris, J., & Wardle, J. (2014). Hypertension and stroke. In Clinical Naturopathy: An Evidence-Based Guide to Practice (pp. 243-256). Elsevier Australia, Chatswood, NSW, Australia.
  • Sutherland, J. A. (2001). Selected complementary methods and nursing care of the hypertensive client. Holist. Nurs. Pract., 15(4), 4-11.
  • Walker AF, Marakis G, Morris AP, Robinson PA. (2002). Promising hypotensive effect of hawthorn extract: a randomized double-blind pilot study of mild, essential hypertension. Phytother Res. Feb;16(1):48-54. doi: 10.1002/ptr.947. PMID: 11807965.
  • World Health Organization (2013). Global Brief on Hypertension: Silent Killer, Global Public Health Crisis. Erişim adresi: https://iris.who.int/bitstream/handle/10665/79059/W?sequence=1
  • Yang, B., & Liu, P. (2012). Composition and health effects of phenolic compounds in hawthorn (Crataegus spp.) of different origins. J. Sci. Food Agric., 92, 1578–1590.
  • Zheng, X., Li, X., Chen, M., Yang, P., Zhao, X., Zeng, L., OuYang, Y., Yang, Z. & Tian, Z. (2019). The protective role of hawthorn fruit extract against high salt-induced hypertension in Dahl salt-sensitive rats: impact on oxidative stress and metabolic patterns. Food Funct. Feb 20;10(2), 849-858. doi: 10.1039/c8fo01818a. PMID: 30681096.
  • Zorniak, M., Szydlo, B., & Krzeminski, T. F. (2017). Crataegus special extract WS 1442: up-to-date review of experimental and clinical experiences. J. Physiol. Pharmacol., 68(4), 521-526. PMID: 29151068.

Year 2024, Volume: 3 Issue: 2, 1 - 12, 28.12.2024

Pınar Karagül

Abstract

References

  • Bahorun, T., Trotin, F., Pommery, J., Vasseur, J. & Pinkas, M. (1994). Antioxidant activities of Crataegus monogyna extracts. Planta Med. 60(4), 323-328.
  • Bahorun T., Trotin F., Pommery J. et al. (1994). Inhibition of thromboxane A2 biosynthesis in vitro by the main components of Crataegus oxyacantha. Prostaglandins Leukotrienes Essential Fatty Acids (PLEFA), 50(4), 173-175.
  • Batinelli, L., Daniele, C., Cristiani, M., Bisignano, G., Laija, A. &Mazzanti, G. (2006). In vitro antifungal and anti-elastase activity of some aliphatic aldehydes from Olea europaea L. fruit. Phytomed. 13, 558-563.
  • Birman H., Tamer Ş., Melikoğlu G., & Meriçli A.H. (2015). Hypotensive Activity of Crataegus tanacetifolia. J. Fac. Pharm. Istanbul Univ. 34(2), 23-26.
  • Braun, L. & Cohen, M. (2015). Herbs and natural supplements, Volume 2: An evidence-based guide. Elsevier Health Sciences, p. 543-552, Saint Louis.
  • Brouwers, S. & Staessen, J.A. (2021). Arterial hypertension. The Lancet 398(10296), 249-261.
  • Chang, Q., Zuo, Z., Harrison, F. & Chow, M.S.S. (2002). Hawthorn. J. Clin. Pharmacol. 42, 605–612.
  • Chi, B., Zhang, M., Sun, L., Liu, H. & Tian, Z. (2024). Study on the hypotensive effect and mechanism of hawthorn (Crataegus pinnatifida) fruits and hyperoside in spontaneously hypertensive rats. Food Funct.15(10), 5627-5640.
  • Cicero, A.F. (2024). Food Supplementation With Diuripres for Blood Pressure Modulation in Subjects With High-Normal Blood Pressure (CONDOR), 2021-09-01, 60.
  • Cui, T., Li, J.Z., Kayahara, H., Ma, L., Wu, L.X. & Nakamura, K. (2006). Quantification of the polyphenols and triterpene acids in Chinese hawthorn fruit by high-performance liquid chromatography. J. Agric. Food Chem. 54, 4574–4581.
  • Hill, C. (2013). Nitric Oxide mediated vasodilatory response to Hawthorn standardized extract. University of North Carolina, 2010-05, 45.
  • Du, W., Fan, H.M., Zhang, Y.X., Jiang, X.H. & Li, Y. (2022). Effect of flavonoids in Hawthorn and Vitamin C prevents hypertension in rats induced by heat exposure. Molecules 27(3), 866.
  • Edwards, J.E., Brown, P.N., Talent, N., Dickinson, T.A. & Shipley, P.R. (2012). A review of the chemistry of the genus Crataegus. Phytochem. 79, 5–26.
  • European Society of Cardiology (ESC) (2024). "https://www.escardio.org/“, Erişim Tarihi: 25.12.2024.
  • European Society of Hypertension, (ESH) (2024). "https://www.eshonline.org/", Erişim Tarihi: 25.12.2024.
  • Fisher, C. (2009). Materia Medica of Western Herbs. Vitex Medica, Nelson, New Zealand.
  • Guo, R., Pittler, M.H. & Ernst, E. (2008). Hawthorn extract for treating chronic heart failure (Review). Cochrane Datab. Syst. Rev. (Online).
  • Guo, R., Pittler, M. H., Schmidt, K. & Ernst, E. (2003). Hawthorn extract for treating chronic heart failure: meta-analysis of randomized trials. Amer. J. Medic. 114(8), 665-674.
  • Graham, J. D. (1939). The Influence of Traditional Remedies on Cardiovascular Health. Journal of Ethnobotany, 12(4), 21
  • Holubarsch, C. J., Meinertz, W. S. C. T., Gaus, W., & Tendera, M. (2008). The efficacy and safety of Crataegus extract WS® 1442 in patients with heart failure: the SPICE trial. Eur. J. Heart Fail., 10(12), 1255-1263.
  • Jalali, A. S., Hasanzadeh, S., & Malekinejad, H. (2012). Crataegus monogyna aqueous extract ameliorates cyclophosphamide-induced toxicity in rat testis: stereological evidences. Acta Med Iran., 50(1), 1-8. PMID: 22267371.
  • Joey P. Granger (2006). An emerging role for inflammatory cytokines in hypertension , Am J Physiol Heart Circ Physiol, 290: 923–924.
  • J. Vibes, B. Lasserre, J. & Gleye, C. (1994). Declume, Inhibition of thromboxane A2 biosynthesis in vitro by the main components of Crataegus oxyacantha (Hawthorn) flower heads, Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 50(4), 173-175.
  • Kazemi, E., Mansoursamaei, A., Bijan, M., Hosseinzadeh, A., Namavar, H., Javedani Masroor, M., & Sheibani, H. (2024). Effect of Crataegus oxyacantha on high blood pressure: A randomized single-blind controlled trial. Advances in Integrative Medicine.
  • Koçyildiz, Z.C., Birman, H., Olgaç, V., Akgün-Dar, K., Melikoğlu, G. & Meriçli, A.H. (2006). Crataegus tanacetifolia leaf extract prevents L-NAME-induced hypertension in rats: a morphological study. Phytother Res. Jan; 20(1),66-70.
  • Lillian Barros, Carvalho, A. M., & Ferreira, I. C. F. R. (2011). Phytochem. Anal., 22, 181–188.
  • Martinelli, F., Perrone, A., Yousefi, S., et al. (2021). Botanical, Phytochemical, Anti-Microbial and Pharmaceutical Characteristics of Hawthorn (Crataegus monogyna Jacq.), Rosaceae. Molecules, 26, 7266.
  • Mark Houston, (2019). Effect of a Nitric Oxide Supplementation Product on Endothelial Dysfunction and Prehypertensive Adults, Hypertension Institute, 2017-04-05,42.
  • Alexander, M., Sarris, J. & Wardle, J. (Eds.) (2014). Hypertension and stroke, Clinical Naturopathy: An Evidence-Based Guide to Practice, Elsevier, Australia, Chatswood, NSW, Australia (2014), pp. 243-256
  • McEwen, B.J. (2015). The of herbal medicine on platelet function and coagulation: A narrative review, Semin. Thromb. Hemost. 41(3), 300-314.
  • Nabavi, S. F., Nabavi, S. M., & Moghaddam, A. H. et al. (2012). Protective effects of Allium paradoxum against gentamicin-induced nephrotoxicity in mice. Food Funct., 3, 28–29.
  • Nabavi, S. F., Nabavi, S. M., Setzer, W., & Nabavi, S. A., et al. (2014). İnsan miR-17–3p ekspresyonunun metil 3-O-metil gallat tarafından modüle edilmesi. Mol. Nutr. Food Res., 58, 1776–1784.
  • Nabavi, S. F., Habtemariam, S., Ahmed, T., Sureda, A., Daglia, M., Sobarzo-Sánchez, E., & Nabavi, S. M. (2015). Polyphenolic Composition of Crataegus monogyna Jacq.: From Chemistry to Medical Applications. Nutrients, 7(9), 7708-7728.
  • Ornelas-Lim, C., Luna-Vázquez, F.J., Rojas-Molina, A. & Ibarra-Alvarad, C. (2021). Development of a quantified herbal extract of hawthorn Crataegus mexicana leaves with vasodilator effect. Saudi Pharm J. Nov; 29(11), 1258-1266. doi: 10.1016/j.jsps.2021.10.002. Epub 2021 Oct 19. PMID: 34819787; PMCID: PMC8596289.
  • Pelliccia, F. (2013). Prehypertension and Dietary Supplements - The PYRAMIDS Study (PYRAMIDS), University of Johannesburg, 2014-10, 30.
  • Rigelsky, J.M, & Sweet, B.V. (2002). Hawthorn: Pharmacology and therapeutic uses. Am J Health Syst Pharm. 59, 417-422.
  • Sarris, J., & Wardle, J. (2014). Hypertension and stroke. In Clinical Naturopathy: An Evidence-Based Guide to Practice (pp. 243-256). Elsevier Australia, Chatswood, NSW, Australia.
  • Sutherland, J. A. (2001). Selected complementary methods and nursing care of the hypertensive client. Holist. Nurs. Pract., 15(4), 4-11.
  • Walker AF, Marakis G, Morris AP, Robinson PA. (2002). Promising hypotensive effect of hawthorn extract: a randomized double-blind pilot study of mild, essential hypertension. Phytother Res. Feb;16(1):48-54. doi: 10.1002/ptr.947. PMID: 11807965.
  • World Health Organization (2013). Global Brief on Hypertension: Silent Killer, Global Public Health Crisis. Erişim adresi: https://iris.who.int/bitstream/handle/10665/79059/W?sequence=1
  • Yang, B., & Liu, P. (2012). Composition and health effects of phenolic compounds in hawthorn (Crataegus spp.) of different origins. J. Sci. Food Agric., 92, 1578–1590.
  • Zheng, X., Li, X., Chen, M., Yang, P., Zhao, X., Zeng, L., OuYang, Y., Yang, Z. & Tian, Z. (2019). The protective role of hawthorn fruit extract against high salt-induced hypertension in Dahl salt-sensitive rats: impact on oxidative stress and metabolic patterns. Food Funct. Feb 20;10(2), 849-858. doi: 10.1039/c8fo01818a. PMID: 30681096.
  • Zorniak, M., Szydlo, B., & Krzeminski, T. F. (2017). Crataegus special extract WS 1442: up-to-date review of experimental and clinical experiences. J. Physiol. Pharmacol., 68(4), 521-526. PMID: 29151068.
There are 43 citations in total.

Details

Primary Language Turkish
Subjects Horticultural Production (Other)
Journal Section Süs ve Tıbbi Bitkiler Botanik Bahçesi Dergisi 3(2)
Authors

Pınar Karagül

Publication Date December 28, 2024
Submission Date December 7, 2024
Acceptance Date December 25, 2024
Published in Issue Year 2024 Volume: 3 Issue: 2

Cite

APA Karagül, P. (2024). Alıç Meyvesi ve Yaprağı (Crataegus Spp.): Hipertansiyona Karşı Tedavi Edici Potansiyeli Üzerine Bir İnceleme. Düzce Üniversitesi Süs Ve Tıbbi Bitkiler Botanik Bahçesi Dergisi, 3(2), 1-12.
AMA Karagül P. Alıç Meyvesi ve Yaprağı (Crataegus Spp.): Hipertansiyona Karşı Tedavi Edici Potansiyeli Üzerine Bir İnceleme. DUSTIBID. December 2024;3(2):1-12.
Chicago Karagül, Pınar. “Alıç Meyvesi Ve Yaprağı (Crataegus Spp.): Hipertansiyona Karşı Tedavi Edici Potansiyeli Üzerine Bir İnceleme”. Düzce Üniversitesi Süs Ve Tıbbi Bitkiler Botanik Bahçesi Dergisi 3, no. 2 (December 2024): 1-12.
EndNote Karagül P (December 1, 2024) Alıç Meyvesi ve Yaprağı (Crataegus Spp.): Hipertansiyona Karşı Tedavi Edici Potansiyeli Üzerine Bir İnceleme. Düzce Üniversitesi Süs ve Tıbbi Bitkiler Botanik Bahçesi Dergisi 3 2 1–12.
IEEE P. Karagül, “Alıç Meyvesi ve Yaprağı (Crataegus Spp.): Hipertansiyona Karşı Tedavi Edici Potansiyeli Üzerine Bir İnceleme”, DUSTIBID, vol. 3, no. 2, pp. 1–12, 2024.
ISNAD Karagül, Pınar. “Alıç Meyvesi Ve Yaprağı (Crataegus Spp.): Hipertansiyona Karşı Tedavi Edici Potansiyeli Üzerine Bir İnceleme”. Düzce Üniversitesi Süs ve Tıbbi Bitkiler Botanik Bahçesi Dergisi 3/2 (December 2024), 1-12.
JAMA Karagül P. Alıç Meyvesi ve Yaprağı (Crataegus Spp.): Hipertansiyona Karşı Tedavi Edici Potansiyeli Üzerine Bir İnceleme. DUSTIBID. 2024;3:1–12.
MLA Karagül, Pınar. “Alıç Meyvesi Ve Yaprağı (Crataegus Spp.): Hipertansiyona Karşı Tedavi Edici Potansiyeli Üzerine Bir İnceleme”. Düzce Üniversitesi Süs Ve Tıbbi Bitkiler Botanik Bahçesi Dergisi, vol. 3, no. 2, 2024, pp. 1-12.
Vancouver Karagül P. Alıç Meyvesi ve Yaprağı (Crataegus Spp.): Hipertansiyona Karşı Tedavi Edici Potansiyeli Üzerine Bir İnceleme. DUSTIBID. 2024;3(2):1-12.
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