Comparative Evaluation of Intramuscular, Intranasal, Oral and Intraosseal Administration of Midazolam, Ketamine Combination in Quail (Coturnix coturnix japonica)

Year 2018, Volume: 11 Issue: 2, 60 - 63, 31.12.2018

Sadık Yayla Engin Kılıç Uğur Aydın , İlksen Dönmez , Celal Şahin Ermutlu , Vedat Baran Mete Cihan , İsa Özaydın , Uğur Yıldız

Abstract

This study was aimed to compare the effects of
different delivery routes of midazolam ketamine combination in quails. Thirty
two adult male quails (Coturnix coturnix japonica) with a mean weight of
180-220 gr and a 25-week-old were used in this study.  The birds were divided into four groups of
eight animals each. In group I (Group IM), 6 mg/kg midazolam-100 mg/kg ketamine
combination was injected intramuscularly. It was given the same dose of this
combination intranasal in the group II (Group IN) and orally in the group III
(Group O). In the last group (Group IO), 2 mg/kg midazolam-20 mg/kg ketamine
was administered intraosseally. Induction, recovery time and depth of
anesthesia were evaluated. Pulse, systolic blood pressure, diastolic blood
pressure, respiratory rate and cloacal temperature were also monitored. The
anesthesia durations were determined as 28.88±5.87 min in group IM, 13.75±5.18
min in group IN, 14.88±4.79 min in group O and 38.13±8.84 min in group IO,
respectively. There were statistically significant differences between groups
in terms of both anesthesia duration and physiological values. As a result,
intramuscular and oral administration of the midazolam ketamine combination may
be preferred to many operative interventions, but intranasal use can be used
for clinical examination or diagnostic procedures because it does not provide
adequate anesthesia. It can be said that oral and intraosseous use may be
preferred in cases requiring longer duration of anesthesia in birds.

Keywords

Intranasal, Intraosseal, Midazolam-ketamine, Oral, Quail

Bıldırcınlarda (Coturnix coturnix japonica) Midazolam-Ketamin Kombinasyonunun İntramusküler, İntranasal, Oral ve İntraosseal Olarak Uygulanmasının Karşılaştırmalı Olarak Değerlendirilmesi

Abstract

Bu çalışmada midazolam ketamin kombinasyonunun
farklı veriliş yollarının etkilerinin karşılaştırmalı olarak değerlendirilmesi
amaçlandı. Çalışmada toplam 32 adet erkek, ortalama 180-220 gr ağırlığında ve
25 haftalık erişkin bıldırcın (Coturnix coturnix japonica) kullanıldı. Kuşlar
her birinde 8 hayvan olacak şekilde dört gruba ayrıldı. Grup I’de (Grup IM) 6
mg/kg dozunda midazolam-100 mg/kg ketamin kombinasyonu intamusküler olarak
enjekte edildi. Grup II’de aynı dozdaki kombinasyon intranasal (Grup IN), III.
gruba ise oral (Grup O) olarak uygulandı. Son gruba da 2 mg/kg midazolam-20
mg/kg ketamin intraosseal (Grup IO) olarak uygulandı. Anesteziye giriş ve çıkış
süreleri ve anestezi derinliği değerlendirildi. Ayrıca nabız, sistolik ve
diastolik kan basınçları ile solunum sayısı ve kloakal ısı takip edildi.
Anestezi süreleri sırasıyla grup IM’de 28.88±5.87, grup IN’de 13.75±5.18, grup
O’da 14.88±4.79 ve grup IO’de 38.13±8.84 olarak belirlendi. Gruplar arasında
hem anestezi süreleri hem de fizyolojik değerler bakımından istatistiksel
olarak anlamlı farklılıklar bulundu. Sonuç olarak midazolam ketamin
kombinasyonun intramusküler ve oral kullanımı birçok operatif girişim için
tercih edilebilir, fakat intranasal kullanım yeterli derinlikte anestezi
sağlayamadığından dolayı sadece klinik muayene ve diagnostik işlemler için kullanılabilir.
Oral ve intraosseal kullanımın daha uzun süreli bir anestezi gerektiren
olgularda tercih edilebileceği söylenebilir.

Keywords

Bıldırcın, İntranasal, İntraosseal, Midazolam-Ketamin, Oral

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