Effect of Multiple-Dose Administration of Cefquinome on Hematological and Biochemical Parameters in Horse

Year 2019, Volume: 12 Issue: 1, 46 - 52, 30.06.2019

Feray Altan , Hanifi Erol , Semih Altan , Mustafa Arıcan , Muammer Elmas , Kamil Üney

Abstract

The negative impact of multiple ascending doses
of cefquinome (CFQ) on hematological and serum biochemical profile of horse
unknown. The objective of this study was to evaluate the effect of multiple
ascending doses of cefquinome (CFQ) in horses on the following hematological
(WBCs, LYM, MON, GRA, RBCs, HB, HT, MCV, MCH, MCHC, RDW, and PLT) and
biochemical parameters (ALB, ALP, ALT, AST, CH, CR, GGT, LDH, TB, TP, TRIG, and
BUN). The study was performed on the sixteen mature horses (4.6 ± 2.1 years,
302 ± 38 kg). Four dosages of CFQ were applied as Group I; 1 mg/kg, Group II; 2
mg/kg, Group III; 4 mg/kg and Group IV; 6 mg/kg, and each animal received
intravenously a total of 13 injections, administered every 12 h for 7 days. The
hematological and biochemical parameters of horses were monitored on the before
0 day and 1, 3, 7, and 14 days after the administration of the first CFQ. No
significant differences in serum biochemical parameters were found amongst the
groups (p>0.05). Significant differences were found in certain hematological
parameters (MONO, GRAN, RBC, HB, HCT, MCH, and PCT) amongst the groups
(p<0.05) within the reference ranges. These results indicate that the
administration of multiple doses of up to 6 mg/kg of CFQ in the horse had no
clinically significant impact on the blood parameters measured.

Keywords

Horse, safety, cefquinome

Supporting Institution

This study was supported by the Scientific and Technological Research Council of Turkey (SUBAPK).

Atlarda Sefkuinomun Çoklu Doz Uygulamalarının Hematolojik ve Biyokimyasal Parametreler Üzerine Etkisi

Abstract

Sefkuinomun (CFQ) çoklu doz uygulamalarının,
atların hematolojik ve biyokimyasal profilleri üzerinde bir etkisi olup
olmadığı bilinmemektedir. Bu çalışmanın amacı, atlarda çoklu artan CFQ dozlarının
bazı hematolojik (WBC, LYM, MON, GRA, RBC, HB, HT, MCV, MCH, MCHC, RDW ve PLT)
ve biyokimyasal parametreler üzerine (ALB, ALP, ALT, AST, CH, CR, GGT, LDH, TB,
TP, TRIG ve BUN) etkisini belirlemektir. Araştırma 16 adet erişkin at (4.6 ±
2.1 yaş, 302 ± 38 kg) üzerinde gerçekleştirildi. Atlara damar içi olarak 7 gün
boyunca her 12 saatte dört doz seviyesinde CFQ uygulandı: Grup I; 1 mg/kg, Grup
II; 2 mg/kg, Grup III; 4 mg/kg, Grup IV; 6 mg/kg) uygulanan toplam 13
enjeksiyon gerçekleştirildi. Belirlenen hematolojik ve biyokimyasal
parametreler ilaç uygulamasından önce (0 gün) ve ilk CFQ dozunun
uygulanmasından 1, 3, 7 ve 14 gün sonra izlendi. Tedavi günlerinde gruplar
arasında serum biyokimyasal parametrelerinde anlamlı bir fark bulunmadı (p>
0.05). Hematolojik parametrelerde (MONO, GRAN, RBC, HB, HCT, MCH ve PCT) doz
grupları arasında referans değerler içinde anlamlı farklar bulundu (p
<0.05). Bu sonuçlar, atlarda CFQ’un 6 mg/kg kadar çoklu doz uygulamalarının,
değerlendirilen kan parametreleri üzerinde klinik olarak önemli bir etkisi
olmadığını göstermektedir.

Keywords

At, güvenilirlik, sefkuinom

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