Fötal gelişim boyunca koyun ileumundaki Toll-like reseptör 2 ekspresyonu

Year 2019, Volume: 12 Issue: 2, 78 - 82, 31.12.2019

Mehmet Özbek , Emel Ergün , Levent Ergün , Feyzullah Beyaz , Füsun Erhan , Banu Kandil Nuh Yıldırım Özge Özgenç

Abstract

Toll
like reseptörler endojen veya mikrobiyal kompanentlerle aktive olan patern
tanıyan reseptörlerdir.
Bu reseptörler arasında, TLR2 intestinal inflamasyon,
nöromüsküler fonksiyon, enterik sinir sistemi yapısını ve nörokimyasal
kodlamayı düzenler.
Bu çalışmada, prenatal dönemde koyun ileumunda TLR2
ekspresyonunu immunohistokimyasal yöntemle araştırmayı amaçladık. Prenatal
dönemi 3 ayrı bölümde inceledik (60-100, 100-125, 125-150). İntestinal ve
folikülle ilişkili epitelde moderate boyanma gözlenirken, bazı epitel
hücrelerinde yoğun intrasitoplazmik immun reaksiyon gözledik. Ayrıca,
foliküllerdeki hücrelerin büyük çoğunluğunda pozitif reaksiyon belirlendi. Tunika
muskularis, lamina muskularis ve damar duvarlarındaki düz kaslarda da pozitif
reaksiyon gözlendi. Ayrıca, submukozal ve myenterik pleksuslardaki gangliyon
hücreleride pozitif boyanma gösterdi. Sonuç olarak, bu çalışma
prenatal gelişimde koyun ileumunda TLR2 ekspresyon profilini tanımlayan ilk
araştırmadır. İleumdaki TLR2 ontogenezisin doğum öncesi dönemde başladığı
gösterilmiştir.
Hemen hemen tüm intestinal epitel hücreleri ve enterik
nöronlar TLR2 ekspresyonu gösterdi. Düz kaslarda TLR2
ekspresyonunun varlığı, düz kasların kasılma görevi dışında bağışıklık sistemi
ile ilişkili olabileceğini göstermektedir.

Keywords

İleum, M hücresi, Peyer plakları, TLR2

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