Sol Ventriküler Miyokardiyal Performans İndeksinin (Tei indeksi) Term ve Prematüre Yenidoğan Buzağılarda Karşılaştırılması

Year 2021, Volume: 14 Issue: 1, 27 - 30, 30.06.2021

Amir Naseri , Kürşat Turgut , Enes Akyüz , Aybars Akar , Ramazan Yıldız , İsmail Şen

https://doi.org/10.47027/duvetfd.878370

Abstract

Yenidoğan kalbi, hem biyokimyasal hem de yapısal özellikler açısından yetişkin kalbinden farklıdır. İnsan neonatolojisindeki ekokardiyografik çalışmalar, prematüre bebeklerin sol ventrikülünün (LV) miyokardiyal fonksiyonunun zamanında doğan bebeklerden farklı olduğunu göstermektedir. Şimdiye kadar neonatal hayvanlarda miyokardiyal performans indeksini (MPI) içeren hiçbir çalışmaya rastlanılmamıştır. Bu çalışmanın amacı prematüre buzağılarda LV MPI'yi değerlendirmek ve sağlıklı yeni doğmuş buzağılarla karşılaştırmaktır. Gününde doğmuş 10 sağlıklı buzağı ve 20 prematüre buzağı çalışmaya dahil edildi. Ekokardiyografik değerlendirmeler doğumdan sonraki 1, 2 ve 3. günlerde yapıldı ve izovolümik kontraksiyon zamanı (IVCT), izovolümik relaksasyon süresi (IVRT), ejeksiyon zamanı (ET) ve MPI PW doku Doppler görüntüleme (PW-TDI) ile değerlendirildi. Çalışmanın sonuçları, prematüre buzağıların LV IVRT'sinin sağlıklı term buzağılara göre daha kısa olduğunu gösterdi. Sağlıklı gününde doğmuş buzağıların LVMPI değeri prematüre buzağılara göre daha yüksekti. Sonuç olarak, MPI ölçümü neonatal buzağılarda uygulanabilir bir yöntemdir. Prematüre buzağıların MPI'sindeki önemli düşüşler ve daha kısa IVRT, duktus arteriyozusun (DA) kapanmamasının ve azalmış afterload'un bir sonucu olarak ortaya çıkabilmektedir. Ekokardiyografi ve Doppler görüntüleme tekniği, neonatal buzağılarda kardiyovasküler sistemi incelemek ve izlemek için yararlı araçlar olduğu ortaya konulmuştur.

Keywords

Doppler, Ekokardiyografi, Miyokard performans indeksi, Prematüre

The Comparison of Left Ventricular Myocardial Performance Index (Tei index) in Term and Prema-ture Neonatal Calves

Abstract

The neonatal heart is different from the adult heart in regard to both biochemical and structural features. Echocardiographic studies in human neonatology show that the myocardial function of left ventricle (LV) of premature infants differs from term infants. No study involving myocardial performance index (MPI) in neonatal animals has been performed until now. The objective of the present study was to evaluate LV MPI in premature calves and compare it to healthy newborn term calves. Ten healthy term and 20 premature calves were used. Echocardiographic evaluations were performed at days 1, 2, and 3 after birth and isovolumic contraction time (IVCT), isovolumic relaxation time (IVRT), ejection time (ET), and MPI calculated with PW tissue Doppler imaging (PW-TDI). Results of the study showed that the IVRT of the LV of premature calves was shorter than seen in healthy term calves. The LVMPI of healthy term calves was also higher than in premature calves. In conclusion, MPI measurement is feasible in neonatal calves. Significant decrements in MPI and shorter IVRT of preterm calves could be the result of the non-closure of the ductus arteriosus (DA), and along with the decreased afterload. Echocardiography and Doppler imaging technique are useful tools for exploring and follow up the cardiovascular system in neonatal calves.

Keywords

Doppler, echocardiography, myocardial performance index, premature

References

• 1. Mourani PM, Ivy DD, Rosenberg AA, Fagan TE, Abman SH. (2008). Left Ventricular Diastolic Dysfunction in Bronchopulmonary Dysplasia. J Pediatr. 152(2): 291-293. doi:10.1016/j.jpeds.2007.11.006
• 2. Czernik C, Rhode S, Metze B, Schmalisch G, Bührer C. (2012). Persistently elevated right ventricular index of myocardial performance in preterm infants with incipient bronchopulmonary dysplasia. PLoS One. 7(6). doi:10.1371/journal.pone.0038352
• 3. Tei C. (1995). New non-invasive index for combined systolic and diastolic ventricular function. J Cardiol. 26(2): 135-136.
• 4. Tekten T, Onbaşili AO, Ceyhan C, Ünal S, Aǧaoǧlu P. (2003). Tissue Doppler myocardial performance index. Turk Kardiyol Dern Ars. 31(5): 262-269.
• 5. Moller JE, Sondergaard E, Poulsen SH, Appleton CP, Egstrup K. (2001). Serial Doppler echocardiographic assessment of left and right ventricular performance after a first myocardial infarction. J Am Soc Echocardiogr. 14(4): 249-255. doi:10.1067/mje.2001.111478
• 6. Brunelli CP, Poulsen SH, Nielsen JC. (2000). The Influence of Heart Rate on the Doppler-Derived Myocardial Performance Index. J Am Soc Echocardiogr. 13(5): 0379-0384. doi:10.1067/mje.2000.104061
• 7. Tei C, Dujardin KS, Hodge DO, et al. (1996). Doppler echocardiographic index for assessment of global right ventricular function. J Am Soc Echocardiogr. 9(6): 838-847. doi:10.1016/S0894-7317(96)90476-9
• 8. Nishimura E, Ikeda S, Naito T, et al. (1999). Evaluation of right-ventricular function by Doppler echocardiography in patients with chronic respiratory failure. J Int Med Res. 27(2): 65-73. doi:10.1177/030006059902700202
• 9. Moller JE, Poulsen SH, Egstrup K. (1999). Effect of preload alternations on a new Doppler echocardiographic index of combined systolic and diastolic performance. In: Journal of the American Society of Echocardiography. 12: 1065-1072. doi:10.1016/S0894-7317(99)70103-3
• 10. Goroshi M, Chand D. (2016). Myocardial Performance Index (Tei Index): A simple tool to identify cardiac dysfunction in patients with diabetes mellitus. Indian Heart J. 68(1): 83-87. doi:10.1016/j.ihj.2015.06.022
• 11. Bokiniec R, Własienko P, Borszewska-Kornacka MK, Madajczak D, Szymkiewicz-Dangel J. (2016). Myocardial performance index (Tei index) in term and preterm neonates during the neonatal period. Kardiol Pol. 74(9): 1002-1009. doi:10.5603/KP.a2016.0056
• 12. Murase M, Ishida A, Morisawa T. (2009). Left and right ventricular myocardial performance index (Tei index) in very-low-birth-weight infants. Pediatr Cardiol. 30(7): 928-935. doi:10.1007/s00246-009-9464-8
• 13. Teitel DF, Iwamoto HS, Rudolph AM. (1990). Changes in the pulmonary circulation during birth-related events. Pediatr Res. 27(4): 372-378. doi:10.1203/00006450-199004000-00010
• 14. Agha HM, Hamza HS, Kotby A, Ganzoury MEL, Soliman N. (2017). Predictors of transient left ventricular dysfunction following transcatheter patent ductus arteriosus closure in pediatric age LV systolic dysfunction after transcatheter PDA closure. J Saudi Hear Assoc. 29(4): 244-251. doi:10.1016/j.jsha.2017.02.002
• 15. Elsheikh RG, Hegab MS, Salama MM. (2015). Echocardiograpic Evaluation of Short-term Outcome of Patent Ductus Arteriosus Closure using Amplatzer Occluder Device. J Cardiovasc Dis Diagnosis. 3(220): 2. doi:10.4172/2329-9517.1000220
• 16. Naseri A, Turgut K, Sen I, Ider M. (2020). Chronological echocardiographic evaluation of left ventricular systolic and diastolic function in term and premature neonatal calves. Theriogenology. 158: 461-469. doi:10.1016/j.theriogenology.2020.10.011
• 17. Aydogdu U, Yildiz R, Guzelbektes H, Coskun A, Sen I. (2016). Cardiac biomarkers in premature calves with respiratory distress syndrome. Acta Vet Hung. 64(1): 38-46. doi:10.1556/004.2016.004
• 18. Radostits O, Gay C, Hinchcliff K, Constable P. (2007). A Textbook of the Diseases of Cattle, Horses, Sheep, Pigs and Goats: Veterinary Medicine. Vol 10. Elsevier Health Sciences.
• 19. Yildiz R, Ok M. (2017). Clinical efficacy of combinations of nebulised fluticasone, salbutamol and furosemide on lung function in premature calves with respiratory distress syndrome. Vet Med (Praha). 62(10): 541-552. doi:10.17221/34/2017-VETMED
• 20. AmorosO EC, Dawes GS, Mott JC. (1958). Patency of the ductus arteriosus in the newborn calf and foal. Br Heart J. 20(1): 92-96. doi:10.1136/hrt.20.1.92
• 21. Kozák-Bárány A, Jokinen E, Saraste M, Tuominen J, Välimäki I. (2001). Development of left ventricular systolic and diastolic function in preterm infants during the first month of life: A prospective follow-up study. J Pediatr. 139(4): 539-545. doi:10.1067/mpd.2001.118199
• 22. Hirose A, Khoo NS, Aziz K, et al. (2015). Evolution of left ventricular function in the preterm infant. J Am Soc Echocardiogr. 28(3): 302-308. doi:10.1016/j.echo.2014.10.017
• 23. Noori S, Friedlich P, Seri I, Wong P. (2007). Changes in Myocardial Function and Hemodynamics after Ligation of the Ductus Arteriosus in Preterm Infants. J Pediatr. 150(6):597-602. doi:10.1016/j.jpeds.2007.01.035