Parvoviral Enteritise Bağlı Septik veya Septik Olmayan Köpeklerde Hematolojik Durum

Year 2022, Volume: 15 Issue: 1, 45 - 52, 30.06.2022

Erdem Gülersoy , Amir Naseri

https://doi.org/10.47027/duvetfd.1100794

Abstract

1 yaşından küçük köpeklerde kanin parvovirus (CPV) önemli bir morbidite ve mortalite sebebidir. Kanin parvoviral enteritis (CPE), sepsis gelişimi için predispoze edici bir faktördür. Hastalığa verilen yangısal cevap, sepsis varlığında gözlenen değişimler için prediktif bir değere sahip olabilir. Bu sebeple, CPE’li septik bir köpeğe diagnostik yaklaşım klinik muayeneleri takiben hemogram gibi rutin laboravutar muayenelerini içermelidir. Bu çalışmanın hayvan materyalini 4-6 aylık, sağlıklı 7 adet (Kontrol Grubu), anoreksi, kusma ve hemorajik enteritis gibi CPE’nin klinik bulgularına sahip 54 adet hasta (CPE Grubu), toplam 61 adet köpek oluşturdu. 2001 SIRS kriterleri doğrultusunda CPE grubu köpekleri Septik CPE (n: 25) ve Non Septik CPE (n: 29) alt gruplarına ayrıldı. Tüm köpeklerin klinik muayeneleri ve venöz kan örneklerinden hemogram analizleri yapıldı. Kontrol grubu ile karşılaştırıldığında CPE grubu köpeklerinin RR, HR ve vücut sıcaklığı değerleri daha yüksek (p<0.000), CRT değeri ise daha kısaydı (p<0.014). Septik CPE ve Non Septik CPE gruplarının karşılaştırılmasında ise RR değeri Septik CPE grubunda daha düşüktü (p<0.001). Kontrol grubu ile karşılaştırıldığında CPE grubunun WBC, granülosit, MCH, MCHC ve Hb değerleri daha düşük (p<0.031), RDW değeri ise daha yüksekti (p<0.001). Septik CPE ve Non Septik CPE gruplarının karşılaştırmasında ise Septik CPE grubunun WBC, lenfosit, monosit, granülosit değerleri daha düşük (p<0.006), MCH değeri ise daha yüksekti (p<0.004). Sonuç olarak, ROC temelli diagnostic performans analizi doğrultusunda RR, WBC, lenfosit, MCH, monosit ve granülosit değerlerinin ise septik ve non septik CPE’li köpeklerin ayırt edilmesinde faydalı diagnostik bilgi sağlayıp, triajda hastalık şiddetini daha erken tanımlayıp erken müdahale ile hayatta kalma oranını arttırabileceği kanısına varıldı.

Keywords

Hemogram, köpek, parvoviral enterit, sepsis

Hematological Status in Septic or Non Septic Dogs due to Parvoviral Enteritis

Abstract

Canine parvovirus (CPV) is an important cause of morbidity and mortality for dogs younger than 1 year-old. Canine parvoviral enteritis (CPE) is a predisposing factor for the development of sepsis. The inflammatory response to the disease may have predictive value for the alterations in the presence of sepsis. Therefore, the diagnostic approach to a septic dog with CPE should include clinical examinations followed by routine laboratory examinations such as hemogram. In this study, a total of 61 dogs, aged 4-6 months, 7 healthy (Control Group) and 54 diseased dogs with clinical signs of CPE such as anorexia, vomiting and hemorrhagic enteritis (CPE Group) were used. CPE group was divided into Septic CPE (n: 25) and Non Septic CPE (n: 29) subgroups in accordance with 2001 systemic inflammatory response syndrome (SIRS) criterias. Clinical examinations and hemogram analysis from venous blood samples were performed. When compared to the Control group, the respiratory rate (RR), heart rate (HR) and body temperature of the dogs in the CPE group were higher (p<0.000) and the capillary refill time (CRT) was shorter (p<0.014). In the comparison of Septic CPE and Non Septic CPE groups, the RR was higher in the Septic CPE group (p<0.001). When compared to the Control group, the leukocytes (WBC), granulocyte, mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC) and hemoglobin (Hb) values of the CPE group were lower (p<0.031) and the reticulocyte distribution width (RDW) value was higher (p<0.001). In the comparison of Septic CPE and Non Septic CPE groups, WBC, lymphocyte, monocytes and granulocyte values of the Septic CPE group were lower (p<0.006) and MCH values were higher (p<0.004). As a result, it was concluded that in accordance with the receiver operating characteristic (ROC) based diagnostic performance analysis, RR, WBC, lymphocyte, MCH, monocytes and granulocyte values can provide useful diagnostic information in differentiating dogs with septic and non septic CPE and may help identifying the disease severity earlier in triage and increase survival rate with early intervention.

Keywords

Dog, hemogram, parvoviral enteritis, sepsis

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