Inhibitory Properties of Aniline, Aminophenol Compounds and their N-acetylated Derivatives on Carbonic Anhydrase

Year 2018, Volume: 4 Issue: 1, 1 - 8, 31.05.2018

Kani Zilbeyaz , Nashia Stellenboom , Murat Guney , Murat Senturk

Abstract

Carbonic anhydrases (CAs) are a group of
metalloenzymes responsible for speeding up the conversion of carbon dioxide and
water to a bicarbonate ion and a proton. CAs is divided into seven well-defined
classes, namely, alpha, beta, gamma, delta, zeta, eta and theta. The alpha
class of CAs is found in animal systems and is involved in various
physiological and pathological processes. In some cases CA inhibition is
required to treat certain disorders. Over the years metal complexing anions and
sulfonamide compounds have been used extensively for this purpose. This paper
investigated the potential inhibitory properties of aminophenol (AP) compounds
and their acetylated derivatives against human cytosolic carbonic anhydrase
(hCA) isozymes I and II. 

Keywords

Carbonic anhydrase, aminophenol, inhibitory

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