İskemik ve Hemorajik Serebrovasküler Olay Tanılı Hastalarda Kan Parametrelerinin Prognostik Değeri

Year 2024, Volume: 6 Issue: 3, 119 - 122, 31.12.2024

Sema Ayten

https://doi.org/10.55994/ejcc.1608086

Abstract

GİRİŞ
Serebral enfarktüs, intraserebral kanama (ICH) ve subaraknoid kanama (SAK) sonucu ortaya çıkan akut nörolojik yaralanma inmesi olarak tanımlanır. İnme olgularının %80-85'i iskemik gruptadır. Hemorajik inme bu olguların yaklaşık %10-30'undan sorumludur. Çalışmalar, ortaya çıkan inflamatuar yanıtın iskemik beyin hasarını ve nörolojik disfonksiyonu şiddetlendirdiğini göstermiştir.

GEREÇ VE YÖNTEM
İstanbul'da üçüncü basamak bir devlet hastanesine son altı ay içinde başvuran ve inme tanısı alan hastalar retrospektif olarak incelendi. Çalışmada inme tanısı konulan 116 hastanın başvuru anında alınan kan örnekleri incelendi ve tam kan sayımında nötrofil ve lenfosit değerleri kullanıldı. Nötrofil/Lenfosit oranları (NLO) bu değerler çıkarılarak hesaplandı. Hastaların hastanede kalış süreleri kaydedildi. Olguların NLO değerlerinin hastanede kalış süreleri ile korelasyonu incelendi.

BULGULAR
Çalışmaya dahil edilen 116 hastanın 100'ünde iskemik inme, 16'sında hemorajik inme vardı. İncelenen olguların 63'ü erkek, 53'ü kadındı. Yaş ortalaması 71,6±11,6 yıldı. Hemorajik inme ve iskemik inme grupları arasında yaş ve cinsiyet açısından istatistiksel olarak anlamlı fark yoktu. Hastaların hastanede kalış süreleri ile NLO değerleri arasındaki korelasyonu inceledik. İskemik inme ve hemorajik inme hasta gruplarında yatış süresi ile NLO arasında istatistiksel olarak anlamlı bir ilişki olmadığını saptadık. Benzer şekilde, hastanede kalış süresi ve NLO düzeylerini incelediğimizde, zayıf ve istatistiksel olarak anlamlı bir korelasyon olmadığını gösterdik.

SONUÇ
Literatürde yüksek nötrofil ve düşük lenfosit değerlerinin mortalite ve morbidite üzerine olumsuz etkisi olduğunu gösteren çok sayıda çalışma olmasına rağmen, bizim çalışmamızdaki gibi bir etkisi gösterilememiş çalışmalar da mevcuttur.

Keywords

SVO,İnme, nötrofil, lenfosit, NLO

Prognostic Value of Blood Parameters in Patients Diagnosed with Ischemic and Hemorrhagic Cerebrovascular Events

Abstract

INTRODUCTION
Cerebral infarction is defined as an acute neurological injury stroke that occurs as a result of intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SAH). 80-85% of stroke cases are ischemic group. Hemorrhagic stroke is responsible for approximately 10-30% of these cases. Studies have shown that the inflammatory response that occurs exacerbates ischemic brain injury and neurological dysfunction.

MATERIALS AND METHODS
Patients who were admitted to a tertiary state hospital in Istanbul in the last six months and diagnosed with stroke were retrospectively analyzed. Blood samples taken at the time of admission of 116 patients with stroke diagnosed in the study were examined and neutrophil and lymphocyte values in the complete blood count were used in the study. Neutrophil/Lymphocyte ratios (NLR) were calculated by subtracting these values. Hospitalization times of the patients were recorded. The correlation of NLR values of the cases with the length of hospital stay was examined.

RESULTS
Of the 116 patients included in the study, 100 had ischemic stroke and 16 had hemorrhagic stroke. Of the cases examined, 63 were male and 53 were female. The mean age was 71.6±11.6 years. There was no statistically significant difference between hemorrhagic stroke and ischemic stroke groups in terms of age and gender. We examined the correlation between the length of hospital stay and NLR values of the patients. We found that there was no statistically significant correlation between length of stay and NLR in ischemic stroke and hemorrhagic stroke patient groups. Likewise, when we examined the length of hospitalization and NLR levels, we showed that there was no weak and statistically significant correlation.

CONCLUSION
Although there are many studies in the literature showing that high neutrophil and low lymphocyte values have a negative effect on mortality and morbidity, there are also studies that have not been shown to have an effect as in our study.

Keywords

Stroke, neutrophil, lymphocyte, NLR

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