Synthesis and characterization of new Piperazine-Dithiocarbamate compounds as potent MAO-A inhibitors

Year 2022, Volume: 1 Issue: 1, 1 - 7, 29.04.2022

Derya Osmaniye , Begüm Nurpelin Saglik , Serkan Levent , Yusuf Özkay , Zafer Asım Kaplancıklı

https://doi.org/10.55971/EJLS.1089254

Abstract

Monoamine oxidase (MAO) enzymes have an important place in neurodegenerative diseases. While MAO-A inhibitors are used in depression; MAO-B enzyme has an important place in Parkinson's disease. Within the scope of this study, 7 new piperazine-dithiocarbamate derivative compounds were synthesized. Structure determinations of the compounds were performed using 1H-NMR, ¹³C-NMR and HRMS spectroscopic methods. The MAO inhibitory activities of the compounds were determined by in vitro fluorometric methods. According to the obtained results, compound 2d with IC₅₀=0.108±0.004 µM; compound 2e exhibited inhibitory activity with an IC₅₀=0.074±0.003 µM.

Keywords

Dithiocarbamate, HRMS, Monoamine oxidase, NMR, Piperazine

Thanks

As the authors of this study, we thank Anadolu University Faculty of Pharmacy Central Laboratory for their support and contributions.

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