Synthesis, biological activity evaluation and molecular docking studies of novel thiazole derivatives

Year 2023, Volume: 2 Issue: 1, 1 - 24, 24.04.2023

Derya Osmaniye , Uğur Kayiş , Ülküye Dudu Gül , Yusuf Özkay , Zafer Asım Kaplancıklı

https://doi.org/10.55971/EJLS.1270394

Abstract

Resistance to existing drugs develops because of insensible use of antibacterial and antifungal drugs. Therefore, there is a need for the development of new drug candidate compounds. The thiazole ring has many biological activities. It is possible to include antibacterial and antifungal activities among these activities. In addition to these, the thiazole ring has been preferred because it is the bioisostere of the imidazole ring in the structure of many antifungal drugs. For this purpose, within the scope of this study, 7 new thiazole compounds were synthesized, and their structure determinations were carried out using HRMS, 1H-NMR, 13C-NMR spectroscopic methods. Their antibacterial and antifungal activities were investigated by in vitro methods. As a result of activity tests, compound 3e showed activity against C.krusei strain with MIC50=31.25 ug/mL. The potential effectiveness of the compound 3e on the 14alpha-demethylase enzyme (PDB ID:3LD6) was tested by in silico studies.

Keywords

Thiazole, Antibacterial Activity, Antifungal Activity, Molecular Docking

Thanks

As the authors of this study, we thank Anadolu University Faculty of Pharmacy Central Laboratory for their support and contributions.

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