Synthesis of New p-Alkylaminophenol Compounds and Investigation of Their Antimicrobial and Antioxidant Activity

Year 2019, Issue: 16, 701 - 706, 31.08.2019

Yeliz Ulaş , Ahmet İsmail Özkan , Veysel Tolan

https://doi.org/10.31590/ejosat.582483

Cited By: 6

Abstract

Alkylaminophenols are synthetic derivatives well
known for their anticancer activity. In this work, we report the antimicrobial
and antioxidant activity of such compounds. A series (4,5,6) of
alkylaminophenol compounds were prepared with very high yields by Petasis
reaction. Synthesized compounds were characterized by ¹H-NMR and ¹³C-NMR.
The obtained compounds were tested against Gram-positive and Gram-negative
bacteria. The compound 4 showed antimicrobial activity at a concentration of 10
mg/mL, while the 6 compound showed activity on S. aureus. Phenolic compounds
have attracted attention due to their proximal and antioxidant activities.
Since alkylaminophenols have phenolic structure, their antioxidant activity has
been investigated. Thus, drug-active substances with high antioxidant capacity
against diabetes, heart disease, and cancer were synthesized.

Keywords

Alkylaminophenol

Supporting Institution

Bursa Uludag University Scientific Research Projects Unit

Project Number

KUAP(F)-2015/22

Yeni p-alkilaminofenol Bileşiklerinin Sentezi ve Antimikrobiyal ve Antioksidan Aktivitelerinin Araştırılması

Abstract

Alkilaminofenoller antikanser aktivitelerine
sahip iyi bilinen organik yapılardır. Bu çalışmada, yüksek verimlerle petasis
reaksiyonuyla  bir seri (4,5,6)  alkilaminofenol bileşiği sentezlendi.
Sentezlenen bileşikler 'H-NMR ve ¹³C-NMR ile karakterize edildi.
Ardından,bu bileşiklerin antimikrobiyal ve antioksidan aktivitelerini incelendi.
Elde edilen bileşikler, Gram pozitif ve Gram negatif bakterilere karşı test
edildi. 4 nolu bileşiğin , 10 mg / mL konsantrasyonda antimikrobiyal aktivite
gösterirken, 6 nolu bileşiğin, S. aureus'ta aktivite gösterdiği görüldü.
Fenolik bileşikler proksimal ve antioksidan aktivitelerinden dolayı dikkat
çekici yapılardır. Alkilaminofenoller fenolik yapıya sahip olduklarından
antioksidan aktiviteleri de araştırılmıştır. Diyabete, kalp hastalığına ve
kansere karşı yüksek antioksidan kapasiteye sahip ilaç aktif maddeleri;  ilk kez sentezlenmiştir.

Keywords

Alkilaminofenol

Project Number

KUAP(F)-2015/22

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