The Effect of Lithium Toxicity on the Goldfish (Carassius auratus) Brain

Year 2022, Issue: 38, 435 - 439, 31.08.2022

Aslı Çilingir Yeltekin , Sama El-tekreti

https://doi.org/10.31590/ejosat.1139370

Abstract

Although lithium is widely used as a standard in decreasing episodes of depression and mania, for its long-term stabilization and efficacy in reducing suicide risk, its use has recently declined due to side effects and the associated toxicity burden. We did this study with the Carassius auratus fish as a model to learn about the adverse effects and toxicity of lithium on the brain. The spectrophotometric approach was used to investigate the effects of a lithium dosage (50 mg/L) in Carassius auratus at various periods (24 h, 48 h, 72 h, and 96). As a result, the enzymes catalase (CAT), Superoxide Dismutase (SOD), and Glutathione Peroxidase (GSH-Px) in the Carassius auratus brain were shown to be altered by lithium chloride (LiCl).

Keywords

lithium, carsssius auratus, toxicity, SOD, CAT, GSH-Px

Lityum Toksisitesinin Japon Balığı (Carassius auratus) Beynine Etkisi

Abstract

Lityum, depresyon ve mani ataklarını azaltmada yaygın olarak standart olarak kullanılmasına rağmen, uzun vadeli stabilizasyonu ve intihar riskini azaltmadaki etkinliği nedeniyle, kullanımı yan etkiler ve ilişkili toksisite yükü nedeniyle son zamanlarda azalmıştır. Bu çalışmayı, lityumun beyin üzerindeki olumsuz etkileri ve toksisitesini öğrenmek için model olarak Carassius auratus balığı ile yaptık. Lityum dozajının (50 mg/L) Carassius auratus'taki etkilerini çeşitli periyotlarda (24 saat, 48 saat, 72 saat ve 96) araştırmak için spektrofotometrik yaklaşım kullanıldı. Sonuç olarak Carassius auratus beynindeki Katalaz (CAT), Süperoksit Dismutaz (SOD) ve Glutatyon Peroksidaz (GSH-Px) enzimlerinin lityum klorür (LiCl) tarafından değiştirildiği gösterildi.

Keywords

toksite, lithuum, SOD, CAT, GSHP-x, carassius auratus

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