Evaluation of the Patients Admitted to Emergency Department with Paracetamol İntoxication

Year 2019, Volume: 1 Issue: 1, 11 - 14, 01.03.2019

Meral Tandoğan , Emine Emektar , Seda Dağar , Yücel Yüzbaşıoğlu Rabia Handan Karaatlı Yunsur Çevik

Abstract

Aim: We aimed to evaluate the demographical and
clinical variations and treatment and complications of the patients admitted to
emergency department (ED) with paracetamol intoxication.

Material and Method: This is a retrospective
study. Patients who were diagnosed as paracetamol intoxication at the ED of
Keçiören Health Research and Application Center Hospital included into the
study. Patients with missed data, pregnant patients and patients with drug
intoxications other than paracetamol were excluded. Statistical analysis was
performed using the Statistical Package for the Social Sciences version 16.0.  P-value less than 0.05 was considered
statistically significant.

Results:
 Fifty-five patient included into the study.
Mean age of the patients was 34±12 years and 63.6% of them were female. The amount of paracetamol
ingested was 11.02±4.04
gr and fourth hour paracetamol level was 28.8 µg/dl (IQR 25-75: 12.5-41.7).
There was a statistically significant weak correlation between the amount of
paracetamol ingested and the blood paracetamol level of the patients(r=0,475
ve p=0,04). Liver function
tests of the patients were elevated during the follow up and that was
statistically significant (p<0.05).

Conclusion:
According to the
results despite of more than half of the patients ingested paracetamol at toxic
doses, at most of them severity of intoxication was mild. Levels of the liver
function tests of the patients could increase at paracetamol intoxication
compared to baseline levels.

 

Keywords

Paracetamol, intoxication, liver function tests

Acil Servise Parasetamol İntoksikasyonu Nedeniyle Başvuran Hastaların Değerlendirilmesi

Abstract

Amaç: Bu çalışmada, acil kliniğine parasetamol intoksikasyonu nedeniyle başvuran hastaların; demografik, klinik değişkenleri, tedavileri ve komplikasyonlarını değerlendirmeyi amaçladık.

Materyal ve Metot: Bu çalışma retrospektif bir çalışmadır. Keçiören Sağlık Araştırma ve Uygulama Merkezi Hastanesi acil kliniğinde parasetamol intoksikasyonu tanısı alan hastalar çalışmaya dahil edildi. Verileri eksik olanlar, gebeler, parasetamol dışı ilaçlarla zehirlenen hastalar çalışma dışı bırakıldı. Verilerin analizi SPSS 16 programında yapıldı. p<0.05 istatistiksel olarak anlamlı kabul edildi.

Bulgular: Çalışmaya 55 hasta dahil edildi.  Hastaların yaş ortalaması 34±12 yıl olup, %63,6’sı kadındı. Hastaların aldıkları parasetamol miktarı 11.02±4.04 gr ve dördüncü saat parasetamol düzeyleri 28.8 µg/dl (IQR 25-75: 12.5-41.7) olarak bulundu. Hastaların aldıkları parasetamol miktarı ile kan parasetamol düzeyi arasında istatistiksel anlamlı zayıf düzeyde korelasyon saptandı (r=0,475 ve p=0,04). Hastaların takip süresince bakılan karaciğer fonksiyon testlerinde artış saptandı ve bu fark istatistiksel olarak anlamlıydı (p<0.05).

Sonuç: Çalışma bulgularımıza göre hastalarımız yarıdan fazlası toksik doz parasetamol almış olmasına rağmen büyük bir kısmında zehirlenme şiddetinin hafif olduğu görülmüştür. Parasetamol zehirlenmelerinde hastaların karaciğer fonksiyon testlerinde başlangıç değerlerine göre artış olabilmektedir.

Keywords

Parasetamol, zehirlenme, karaciğer fonksiyon testleri

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