Case Report
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Year 2019, Volume: 1 Issue: 2, 65 - 68, 17.07.2019

Seda Dağar , Emine Emektar , Meral Tandoğan , Şeref Kerem Çorbacıoğlu , Hüseyin Uzunosmanoğlu , Yunsur Çevik

Abstract

Serotonin sendromu hayatı tehdit eden, istenmeyen bir ilaç reaksiyonudur. Yüksek serotonin düzeylerine ikincil olarak merkezi ve periferik serotonin reseptörlerinde aşırı aktivasyonun neden olduğu semptomların bir birleşimidir. İkinci kuşak bir antipsikotik ajan olan Olanzapin, serotonin reseptörünün bir antagonistidir. Serotonin antagonizmasının etkisine rağmen, olanzapinin serotonin sendromunu paradoksal olarak tetikleyebileceği bildirilmiştir. Bu olgu sunumunda, büllöz ilaç reaksiyonunun eşlik ettiği kronik olanzapin kullanımı nedeniyle oluşan serotonin sendromlu bir hastayı sunuyoruz.

Keywords

serotonin sendromu olanzapin atipik antipsikotik

References

  • 1- Volpi-Abadie J, Kaye AM, Kaye AD. Serotonin syndrome. Ochsner J. 2013; 13(4): 533-40.
  • 2- Monte AA, Waksman JC. Chronic olanzapine, serotonin receptors, and subsequent serotonin toxicity. J Clin Psychopharmacol. 2010; 30(5): 628-9.
  • 3- Boyer EW, Shannon M. The serotonin syndrome. N Engl J Med. 2005; 352: 1112-20.
  • 4- Dunkley EJ, Isbister GK, Sibbritt D, Dawson AH, Whyte IM. The Hunter Serotonin Toxicity Criteria: simple and accurate diagnostic decision rules for serotonin toxicity. QJM. 2003; 96(9): 635-42.
  • 5- McDaniel WW. Serotonin syndrome: early management with cyproheptadine. Ann Pharmacother. 2001; 35(7-8): 870-873.
  • 6- Haslett CD, Kumar S. Can olanzapine be implicated in causing serotonin syndrome? Psychiatry Clin Neurosci. 2002; 56(5): 533-5.
  • 7- Isbister GK, Downes F, Whyte IM. Olanzapine and serotonin toxicity. Psychiatry Clin Neurosci. 2003; 57: 244.

A Rare Cause of Serotonin Syndrome: Chronic Olanzapine Use

Year 2019, Volume: 1 Issue: 2, 65 - 68, 17.07.2019

Seda Dağar , Emine Emektar , Meral Tandoğan , Şeref Kerem Çorbacıoğlu , Hüseyin Uzunosmanoğlu , Yunsur Çevik

Abstract

Serotonin syndrome is a life-threatening, undesirable drug
reaction. It is a combination of symptoms caused by over activation at central
and peripheral serotonin receptors secondary to high serotonin levels.
Olanzapine, a second generation antipsychotic agent, is an antagonist of
serotonin receptor. Despite the effect of serotonin antagonism, it is reported
that olanzapine may paradoxically trigger serotonin syndrome. In this case
report, we present a patient with SS due to chronic olanzapine use accompanied
by bullous drug reaction.

Keywords

serotonin syndrome olanzapine atypical antipsychotic

References

  • 1- Volpi-Abadie J, Kaye AM, Kaye AD. Serotonin syndrome. Ochsner J. 2013; 13(4): 533-40.
  • 2- Monte AA, Waksman JC. Chronic olanzapine, serotonin receptors, and subsequent serotonin toxicity. J Clin Psychopharmacol. 2010; 30(5): 628-9.
  • 3- Boyer EW, Shannon M. The serotonin syndrome. N Engl J Med. 2005; 352: 1112-20.
  • 4- Dunkley EJ, Isbister GK, Sibbritt D, Dawson AH, Whyte IM. The Hunter Serotonin Toxicity Criteria: simple and accurate diagnostic decision rules for serotonin toxicity. QJM. 2003; 96(9): 635-42.
  • 5- McDaniel WW. Serotonin syndrome: early management with cyproheptadine. Ann Pharmacother. 2001; 35(7-8): 870-873.
  • 6- Haslett CD, Kumar S. Can olanzapine be implicated in causing serotonin syndrome? Psychiatry Clin Neurosci. 2002; 56(5): 533-5.
  • 7- Isbister GK, Downes F, Whyte IM. Olanzapine and serotonin toxicity. Psychiatry Clin Neurosci. 2003; 57: 244.
There are 7 citations in total.

Details

Primary Language English
Subjects Emergency Medicine
Journal Section Case Reports
Authors

Seda Dağar 0000-0002-7874-382X

Emine Emektar 0000-0002-6056-4401

Meral Tandoğan 0000-0002-5407-7092

Şeref Kerem Çorbacıoğlu 0000-0001-7802-8087

Hüseyin Uzunosmanoğlu 0000-0002-4370-1283

Yunsur Çevik 0000-0003-1325-0909

Publication Date July 17, 2019
Submission Date January 14, 2019
Published in Issue Year 2019 Volume: 1 Issue: 2

Cite

APA Dağar, S., Emektar, E., Tandoğan, M., Çorbacıoğlu, Ş. K., et al. (2019). A Rare Cause of Serotonin Syndrome: Chronic Olanzapine Use. Eurasian Journal of Toxicology, 1(2), 65-68.
AMA Dağar S, Emektar E, Tandoğan M, Çorbacıoğlu ŞK, Uzunosmanoğlu H, Çevik Y. A Rare Cause of Serotonin Syndrome: Chronic Olanzapine Use. Eurasian J Tox. July 2019;1(2):65-68.
Chicago Dağar, Seda, Emine Emektar, Meral Tandoğan, Şeref Kerem Çorbacıoğlu, Hüseyin Uzunosmanoğlu, and Yunsur Çevik. “A Rare Cause of Serotonin Syndrome: Chronic Olanzapine Use”. Eurasian Journal of Toxicology 1, no. 2 (July 2019): 65-68.
EndNote Dağar S, Emektar E, Tandoğan M, Çorbacıoğlu ŞK, Uzunosmanoğlu H, Çevik Y (July 1, 2019) A Rare Cause of Serotonin Syndrome: Chronic Olanzapine Use. Eurasian Journal of Toxicology 1 2 65–68.
IEEE S. Dağar, E. Emektar, M. Tandoğan, Ş. K. Çorbacıoğlu, H. Uzunosmanoğlu, and Y. Çevik, “A Rare Cause of Serotonin Syndrome: Chronic Olanzapine Use”, Eurasian J Tox, vol. 1, no. 2, pp. 65–68, 2019.
ISNAD Dağar, Seda et al. “A Rare Cause of Serotonin Syndrome: Chronic Olanzapine Use”. Eurasian Journal of Toxicology 1/2 (July 2019), 65-68.
JAMA Dağar S, Emektar E, Tandoğan M, Çorbacıoğlu ŞK, Uzunosmanoğlu H, Çevik Y. A Rare Cause of Serotonin Syndrome: Chronic Olanzapine Use. Eurasian J Tox. 2019;1:65–68.
MLA Dağar, Seda et al. “A Rare Cause of Serotonin Syndrome: Chronic Olanzapine Use”. Eurasian Journal of Toxicology, vol. 1, no. 2, 2019, pp. 65-68.
Vancouver Dağar S, Emektar E, Tandoğan M, Çorbacıoğlu ŞK, Uzunosmanoğlu H, Çevik Y. A Rare Cause of Serotonin Syndrome: Chronic Olanzapine Use. Eurasian J Tox. 2019;1(2):65-8.
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