Acil Serviste Karbonmonoksit Zehirlenmesi Tanısı Alan Hastalarda Plazma Total Tiyol Seviyelerinin Değerlendirilmesi

Year 2023, Volume: 5 Issue: 1, 1 - 4, 30.04.2023

Orhan Delice , Murat Daş , Gülhan Kurtoğlu Çelik , Havva Şahin Kavaklı , Salim Neşelioğlu , Semra Işıkoğlu Hatıl

https://doi.org/10.51262/ejtox.1242709

Cited By: 1

Abstract

Keywords

karbon monoksit zehirlenmesi,, oksidatif stres, total tiyol seviyeleri

Evaluation of Plasma Total Thiol Levels in Patients with Carbon Monoxide Poisoning in the Emergency Department

Abstract

Objective: The study aimed to measure the levels of total thiol, an antioxidant parameter, in patients who presented to the emergency department (ED) with carbon monoxide (CO) poisoning under normobaric oxygen therapy (NBOT), evaluate the time-dependent changes in total thiol levels within the first 6 hours, and examine the course of antioxidants in CO poisoning.
Materials and Method: The study population consisted of 85 patients diagnosed with CO poisoning in the ED and 50 volunteers. Total thiol level was measured in the study group at the admission (T0), first (T1) and sixth hour (T6). Carboxyhemoglobin levels, cardiac markers, electrocardiography, and routinely requested tests were investigated in patients with poisoning. The total thiol level was measured in the volunteer group.
Results: There was a significant decrease in total thiol mean levels between T0 and T1 (p <0.01), a significant increase between T1 and T6 (p <0.01), and a significant increase between T0 and T6 (p <0.01). No significant difference was found for T6 total thiol mean level between the patient and the control group (p >0.05).
Conclusion: The significant decrease in the total thiol mean value from T0 to T1 may suggest that the oxidative stress continues within the first hour, and the initiation of the significant increase in the total thiol level within T1 may indicate that the oxidative stress decreased with treatment. Six hours of NBOT protocol is sufficient for acute CO poisoning in patients not requiring HBOT.

Keywords

carbon monoxide poisoning, oxidative stress, total thiol level

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