Nazal polipozisi olan hastaların trombosit dağılım aralığı (TDA) verileri: Klinik ciddiyet açısından önemli mi?

Year 2017, Volume: 7 Issue: 1, 33 - 37, 30.04.2017

Ahmet Hamdi Kepekçi , Gökalp Dizdar Ali Bestemi Kepekçi

Abstract

Objective: The purpose of the present study was to investigate whether high platelet distribution width (PDW) levels correlated with nasal polyps or not.
Methods: The study was performed retrospectively in 99 patients who underwent endoscopic sinus surgery for nasal polyposis. Data were collected from the routine preoperative hemograms of the patients. The study group was compared with an age- and sex-matched control group including 150 healthy subjects. The Mann-Whitney U test was used to compare the results of the two groups.
Results: The PDW level for the study group was 14.49±2.08, while for the control group it was 13.76±2.14. The PDW levels of the study group were higher than those of the control group, and this difference was statistically significant (p<0.05).
Conclusion: The rise of the PDW levels in patients with nasal polyposis should be investigated for the diagnostic value, and the rise of PDW levels in patients with nasal polyposis may be used for its diagnostic evaluation.

Keywords

nazal polipozis, trombosit dağılım aralığı, enflamasyon

References

• 1. Mackay IS. Rhinitis: mechanisms and management. London: Royal Society of Medicine Services; 1989.
• 2. Hosemann W, Göde U, Wagner W. Epidemiology, pathophysiology of nasal polyposis, and spectrum of endonasal sinus surgery. Am J Otolaryngol 1994;15:85–98.
• 3. Grigoreas C, Vourdas D, Petalas K, Simeonidis G, Demeroutis I, Tsioulos T. Nasal polyps in patients with rhinitis and asthma. Allergy Asthma Proc 2002;23:169–74.
• 4. Arnold GDM, Lund VJ. Clinical rhinology. New York, NY: Thieme; 1990.
• 5. Settipane RA, Peters AT, Chiu AG. Chapter 6: Nasal polyps. Am J Rhinol Allergy 2013;27 Suppl 1:S20–5.
• 6. Newton JR, Ah-See KW. A review of nasal polyposis. Ther Clin Risk Manag 2008;4:507–12.
• 7. Peric A, Vojvodic D, Peric AV, Radulovic V, Miljanovic O. Correlation between cytokine levels in nasal fluid and scored clinical parameters in patients with nasal polyposis. Indian J Otolaryngol Head Neck Surg 2013;65(Suppl 2):295–300.
• 8. Bachert C, Geveart P. Effect of intranasal corticosteroids on release of cytokines and inflammatory mediators. Allergy 1999;54 Suppl 57:116–23.
• 9. Bachert C, Wagenmann M, Hauser U, Rudack C. IL-5 synthesis is upregulated in human nasal polyp tissue. J Allergy Clin Immunol 1997;99(6 Pt 1):837–42.
• 10. Simon HU, Yousefi S, Schranz C, Schapowal A, Bachert C, Blaser K. Direct demonstration of delayed eosinophil apoptosis as a mechanism causing tissue eosinophilia. J Immunol 1997;158: 3902–8.
• 11. Vagdatli E, Gounari E, Lazaridou E, Katsibourlia E, Tsikopoulou F, Labrianou I. Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia 2010;14:28–32.
• 12. Henn V, Slupsky JR, Grafe M, et al. CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. Nature 1998;391(6667):591–4.
• 13. Farias MG, Schunck EG, Dal Bó S, de Castro SM. Definition of reference ranges for the platelet distribution width (PDW): a local need. Clin Chem Lab Med 2010;48:255–7.
• 14. Yilmaz H, Yilmaz G, Mentefle A, Kostako¤lu U, Karahan SC, Köksal ‹. Prognostic impact of platelet distribution width in patients with Crimean–Congo hemorrhagic fever. J Med Virol 2016;88:1862–6.
• 15. Rinia AB, Kostamo K, Ebbens FA, van Drunen CM, Fokkens WJ. Nasal polyposis: a cellular-based approach to answering questions. Allergy 2007;62:348–58.
• 16. Staikuniene J, Vaitkus S, Japertiene LM, Ryskiene S. Association of chronic rhinosinusitis with nasal polyps and asthma: clinical and radiological features, allergy and inflammation markers. Medicina (Kaunas) 2008;44:257–65.
• 17. Boos CJ, Beevers GD, Lip GY. Assessment of platelet activation indices using the ADVIATM 120 amongst ‘high-risk’patients with hypertension. Ann Med 2007;39:72–8.
• 18. Van Cott EM, Fletcher SR, Kratz A. Effects of the blood-collection tube material and long-term storage on platelet activation parameters on the ADVIA 120/2120 hematology system. Lab Hematol 2004;11:71–5.
• 19. Ceylan B, Mete B, Fincanci M, et al. A new model using platelet indices to predict liver fibrosis in patients with chronic hepatitis B infection. Wien Klin Wochenschr 2013;125:453–60.
• 20. Taniguchi M, Higashi N, Ono E, Mita H, Akiyama K. Hyperleukotrieneuria in patients with allergic and inflammatory disease. Allergol Int 2008;57:313–20.
• 21. Di Capite J, Nelson C, Bates G, Parekh AB. Targeting Ca 2+ release–activated Ca 2+ channel channels and leukotriene receptors provides a novel combination strategy for treating nasal polyposis. J Allergy Clin Immunol 2009;124:1014–21.e1–3.
• 22. Tozkoparan E, Deniz O, Ucar E, Bilgic H, Ekiz K. Changes in platelet count and indices in pulmonary tuberculosis. Clin Chem Lab Med 2007;45:1009–13.
• 23. Celikbilek A, Tanik N, Zararsiz G, Celikbilek M. Do platelet indices have a role in benign paroxysmal positional vertigo? Neurol Res 2014;36:763–8.
• 24. Mirvakili A, Dadgarnia MH, Baradaranfar MH, Atighechi S, Zand V, Ansari A. Role of platelet parameters on sudden sensorineural hearing loss: a case-control study in Iran. PloS One 2016;11: e0148149
• 25. Kurt OK, Yildiz N. The importance of laboratory parameters in patients with obstructive sleep apnea syndrome. Blood Coagul Fibrinol 2013;24:371–4.
• 26. Jindal S, Gupta S, Gupta R, et al. Platelet indices in diabetes mellitus: indicators of diabetic microvascular complications. Hematology 2011;16:86–9.
• 27. Topal E, Celiksoy MH, Catal F, Karakoc HT, Karadag A, Sancak R. The platelet parameters as inflammatory markers in preschool children with atopic eczema. Clin Lab 2015;61:493–6.
• 28. Chandrashekar L, Rajappa M, Sundar I, et al. Platelet activation in chronic urticaria and its correlation with disease severity. Platelets 2014;25:162–5.