Biberiye (Rosmarinus officinalis L.) Ekstraktının SW1353 Kondrosarkom Hücrelerinin Oksidan Stres İndeksleri ve Çoğalma Kapasiteleri Üzerindeki Etkileri

Year 2023, , 111 - 117, 01.08.2023

Berivan Cecen Leyla Didem Kozacı

https://doi.org/10.32707/ercivet.1332189

Abstract

Artrit, eklem ağrısı, şişme ve hareket kısıtlılığı gibi semptomlarla karakterizedir. Hastalığın tedavisinde temel amaç ağrı ve iltihabı ortadan kaldırmak ve eklem fonksiyonlarını korumaktır. Artriti tedavi etmek veya bazı rahatsızlıklarını önlemek için belirli formlarda çeşitli bitkisel ilaçlar uygulanır. Bu çalışmada biberiye ekstraktının SW1353 hücre hattı üzerindeki proliferasyon kapasitesi, toplam antioksidan seviyesi (TAS), toplam oksidan seviyesi (TOS) ve oksidatif stres indeksinin (OSİ) etkileri incelenmiştir. Yüksek dozlarda ortaya çıkan biberiye ekstraktının sitotoksik etkisi, farma- kovijilansı kullanımında oldukça dikkat çekmektedir. Bulgularımız, antioksidan özelliklerinden bağımsız olarak düşük konsantrasyonlarda biberiye ekstraktının artritten kaynaklı kıkırdak hasarı tedavisinde kullanılabileceğini göstermektedir.

Keywords

Antioksidan, biberiye özü, kondrosarkom, oksidatif stres indeksi

The Effects of Rosemary (Rosmarinus officinalis L.) Extract on the Oxidant Stress Indexes and Proliferation Capacities of SW1353 Chondrosarcoma Cells

Abstract

Arthritis is characterized by symptoms such as joint pain, swelling, and limitation of movement. The main objectives of treating the disease are eliminating pain and inflammation and protecting joint functions. Several herbal remedies have been reported to be applied in specific forms to treat arthritis or prevent some ailments. In this study, the effects of rosemary extract (RE) were examined in terms of proliferation capacity, total antioxidant status (TAS) and total oxidant status (TOS) and oxidative stress index (OSI) on SW1353 cell line to see whether rosemary extract can be used in the treatment of arthritis. The cytotoxic effect of RE, which appears in high doses, draws attention to its pharmacovigilance in its use. Our findings indicate that RE at low concentrations, regardless of its antioxidant proper- ties, may be utilized to treat arthritis associated with cartilage damage.

Keywords

Antioxidant, chondrosarcoma, oxidative stress index, rosemary extract

References

• Andrade JM, Faustino C, Garcia C, Ladeiras D, Reis CP, Rijo P. Rosmarinus officinalis L.: An update review of its phytochemistry and biological activity. Future Sci OA 2018; 4(4): 283.
• Bagherifard A, Kadijani AA, Yahyazadeh H, Rezaza- deh J, Azizi M, Akbari A, Mirzaei A. The value of serum total oxidant to the antioxidant ratio as a bi- omarker of knee osteoarthritis. Clin Nutr ESPEN 2020; 38: 118-23.
• Bolukbas C, Bolukbas FF, Horoz M, Aslan M, Celik H, Erel O. Increased oxidative stress associated with the severity of the liver disease in various forms of hepatitis B virus infection. BMC Infect Dis 2005; 5 (1): 95.
• Cheung S, Tai J. Anti-proliferative and antioxidant properties of rosemary Rosmarinus officinalis. Oncol Rep 2007; 17(6): 1525-31.
• Chua JR, Jamal S, Riad M, Castrejon I, Malfait A, Block JA, Pincus T. Disease burden in osteoarthritis is similar to that of rheumatoid arthritis at initial rheu- matology visit and significantly greater six months later. Arthritis Rheum 2019; 71(8): 1276-84.
• Demirbag R, Gur M, Yilmaz R, Kunt AS, Erel O, An- dac MH. Influence of oxidative stress on the devel- opment of collateral circulation in total coronary occlusions. Int J Cardiol 2007; 116(1): 14-9.
• Erel O. A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin Biochem 2004; 37(4): 277-85.
• Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem 2005; 38(12): 1103-11.
• Garcia S. Role of semaphorins in immunopathologies and rheumatic diseases. Int J Mol Sci 2019; 20(2): 374.
• Genena AK, Hense H, Smânia Junior A, Souza SM de. Rosemary (Rosmarinus officinalis): A study of the composition, antioxidant and antimicrobial activi- ties of extracts obtained with supercritical carbon dioxide. Food Sci Technol 2008; 28(2): 463-9.
• Giles JL, Polak OJ, Landon J. Disease modifying drugs for rheumatological diseases: A brief history of everything. Donev R. ed. In: Advances in Protein Chemistry and Structural Biology. United Kingdom: Elsevier 2020; pp. 313-48.
• González-Vallinas M, Reglero G, Ramírez de Molina A. Rosemary (Rosmarinus officinalis L.) extract as a potential complementary agent in anticancer therapy. Nutr Cancer 2015; 67(8): 1223-31.
• Hatai B, Banerjee SK. The role of reactive oxygen species (ROS) in osteoarthritis patients. J Pharma- cogn Phytochem 2019; 8(3): 2287-9.
• Jaglanian A, Tsiani E. Rosemary extract inhibits pro- liferation, survival, akt, and mTOR signaling in triple- negative breast cancer cells. Int J Mol Sci 2020; 21 (3): 810.
• Ko S-Y. Effects of plant-derived natural products on inflammatory bone destructive disease. Int J Oral Biol 2019; 44(4): 130-43.
• Ketsawatsakul U. Modulation by bicarbonate of the protective effects of phenolic antioxidants on peroxynitrite-mediated cell cytotoxicity. Science Asia 2007; 33: 273-82.
• Kolasinski SL, Neogi T, Hochberg MC, Oatis C, Guy- att G, Block J, Callahan L, Copenhaver C, Dodge C, Felson D. American College of Rheumatology/ Arthritis Foundation guideline for the management of osteoarthritis of the hand, hip, and knee. Arthritis Rheum 2020; 72(2): 220-33.
• Kose AHP, Patel P, Wani S. Association of herbal plant in Rheumatoid Arthritis studies using in silico approach. IJARIIT 2019; 5(3): 1648-54.
• Lepetsos P, Papavassiliou KA, Papavassiliou AG. Redox and NF-κB signaling in osteoarthritis. Free Radic Biol Med 2019; 132: 90-100.
• Malayoğlu HB. Biberiyenin (Rosmarinus officinalis L.) antioksidan etkisi. Hayvansal Üretim 2010; 51(2): 59 -67.
• Manivasagam T, Arunadevi S, Essa MM, Sara- vanaBabu C, Borah A, Thenmozhi AJ, Qoronfleh MW. Role of oxidative stress and antioxidants in autism. Essa MM, Qoronfleh MW. eds. In: Personal- ized Food Intervention and Therapy for Autism Spectrum Disorder Management. Switzerland: Springer 2020; pp. 193-206.
• Mengoni ES, Vichera G, Rigano LA, Rodriguez- Puebla ML, Galliano SR, Cafferata EE, Pivetta OH, Moreno S, Vojnov AA. Suppression of COX-2, IL-1β and TNF-α expression and leukocyte infiltration in inflamed skin by bioactive compounds from Rosma- rinus officinalis L. Fitoterapia 2011; 82(3): 414-21.
• Miao M, Collins J, Bahnson E, Chubinskaya S, Lo- eser R. Reactive oxygen species regulate fibron- ectin fragments-induced map kinase signaling and metalloproteinase 13 release in human chondro- cytes through nadph oxidase 2 and endocytosis of chondrocyte integrins. Osteoarthr Cartil 2020; 28: S45-6.
• Moore J, Yousef M, Tsiani E. Anticancer effects of rosemary (Rosmarinus officinalis L.) extract and rosemary extract polyphenols. Nutrients 2016; 8 (11): 731.
• Moussa Z, Judeh ZMA, Ahmed SA. Nonenzymatic exogenous and endogenous entioxidants. Das K. ed. In: Free Radical Medicine and Biology. United Kingdom: IntechOpen 2019; p. 95-116.
• Neha K, Haider MR, Pathak A, Yar MS. Medicinal prospects of antioxidants: A review. Eur J Med Chem 2019; 178: 687-704.
• Ng JY, Azizudin AM. Rheumatoid arthritis and osteo- arthritis clinical practice guidelines provide few com- plementary and alternative medicine therapy recom- mendations: A systematic review. Clin Rheumatol 2020; 39(10): 2861-73.
• Ngo DH, Ngo DN, Kim S-K, Vo TS. Antiproliferative effect of aminoethyl-chitooligosaccharide on human Lung A549 cancer cells. Biomolecules 2019; 9(5): 195.
• Oliviero F, Scanu A, Zamudio-Cuevas Y, Punzi L, Spinella P. Anti-inflammatory effects of polyphenols in arthritis. J Sci Food Agric 2018; 98(5): 1653-9.
• Poprac P, Jomova K, Simunkova M, Kollar V, Rhodes CJ, Valko M. Targeting free radicals in oxi- dative stress-related human diseases. Trends Phar- macol Sci 2017; 38(7): 592-607.
• Pradhan A, Bagchi A, De S, Mitra S, Mukherjee S, Ghosh P, Ghosh A, Chatterjee M. Role of redox imbalance and cytokines in mediating oxidative damage and disease progression of patients with rheumatoid arthritis. Free Radic Res 2019; 53(7): 768-79.
• Rehman S, Nabi B, Baboota S, Ali J. Natural Anti- inflammatory agents for the management of osteo- arthritis. Brahmachari G. ed. In: Discovery and De- velopment of Anti-Inflammatory Agents from Natural Products. United Kingdom: Elsevier 2019; pp. 101- 40.
• Saxena R, Batra J. Arthritis as a disease of aging and changes in antioxidant status. Preedy VR and Patel VB. Ed. In: Aging. United Kingdom: Elsevier 2020; pp. 83-94.
• Scheckel KA, Degner SC, Romagnolo DF. Rosma- rinic acid antagonizes activator protein-1– dependent activation of cyclooxygenase-2 expres- sion in human cancer and nonmalignant cell lines. J Nutr 2008; 138(11): 2098-105.
• Schmidt HM, Kelley EE, Straub AC. The impact of xanthine oxidase (XO) on hemolytic diseases. Re- dox Biol 2019; 21: 101072.
• Schroeder K, Pincus T, Bergman M. AB1194 striking differences in the course of osteoarthritis (OA) com- pared to rheumatoid arthritis (RA) over the first 24 months of rheumatology care at one private practice setting. Ann Rheum Dis 2020; 79(1): 1887.
• Shen Y, Han J, Zheng X, Ai B, Yang Y, Xiao D, Zheng L, Sheng Z. Rosemary leaf extract inhibits glycation, breast cancer proliferation and diabetes risks. Appl Sci 2020; 10(7): 2249.
• Sinbad OO, Folorunsho AA, Olabisi OL, Ayoola OA, Temitope EJ. Vitamins as antioxidants. J Food Sci 2019; 2(3): 214-35.
• Suleman M, Khan A, Baqi A, Kakar MS, Ayub M. 2. Antioxidants, its role in preventing free radicals and infectious diseases in human body. Pure Appl Biol 2019; 8(1): 380-8.
• Tejero J, Shiva S, Gladwin MT. Sources of vascular nitric oxide and reactive oxygen species and their regulation. Physiol Rev 2019; 99(1): 311-79.
• Tsiani E. P1. 03-03 Inhibition of H1299 Lung cancer cell proliferation and survival by rosemary extract Is associated with AMPK activation. J Thorac Oncol 2019; 14(10): S418.
• Vallverdú-Queralt A, Regueiro J, Martínez-Huélamo M, Alvarenga JFR, Leal LN, Lamuela-Raventos RM. A comprehensive study on the phenolic profile of widely used culinary herbs and spices: Rosemary, thyme, oregano, cinnamon, cumin and bay. Food Chem 2014; 154: 299-307.
• Vlavcheski F, Tsiani E. Attenuation of free fatty acid- induced muscle insulin resistance by rosemary ex- tract. Nutrients 2018; 10(11): 1623.
• Wu L, Pan Y. Reactive oxygen species mediate TNF- α-induced inflammatory response in bone marrow mesenchymal cells. Iran J Basic Med Sci 2019; 22 (11): 1296.
• Zahan O-M, Serban O, Gherman C, Fodor D. The evaluation of oxidative stress in osteoarthritis. Med Pharm Rep 2020; 93(1): 12-22.
• Zhao D, Gu M-Y, Xu JL, Zhang LJ, Ryu SY, Yang HO. Anti-neuroinflammatory effects of 12- dehydrogingerdione in LPS-activated microglia through inhibiting Akt/IKK/NF-κB pathway and acti- vating Nrf-2/HO-1 pathway. Biomol Ther (Seoul) 2019; 27(1): 92-100.