Sütten Kesilmiş Kuzularda Büyüme Performansı, Pasif Bağışıklık ve Sağlık Arasındaki Ilişki

Year 2024, , 117 - 122, 02.08.2024

Erhan Gökçe , Cemalettin Ayvazoğlu , Pınar Cihan , Onur Atakisi , Ali Haydar Kırmızıgül , Hidayet Metin Erdoğan

https://doi.org/10.32707/ercivet.1517202

Abstract

Bu çalışmanın amacı, sütten kesim dönemi kuzularda pasif bağışıklık transferi ile bazı hastalıklar (ishal, pnömoni, fatigue anoreksi sendromu-FAS) ve büyüme performansı [vücut ağırlığı (BW) ve ortalama günlük ağılık artışı (ADG)] arasındaki ilişkiyi araştırmaktır. Toplam olarak 347 kuzudan kolostrum alınımından ya da doğumdan sonra 24±1 saat kan örnekleri toplanmış ve her bir kuzu için serum IgG konsantrasyonu ticari bir ELISA kiti kullanılarak ölçülmüştür. Kuzular doğumdan hemen sonra (kolostrum alımından önce) tartılmış ve 28. günde (neonatal dönemin sonunda) ve 84. günde (sütten kesim yaşı) tekrar tartılmıştır. Kuzuların ADG'si yaşamın 0 ila 28. günleri arasında, yaşamın 29 ila 84. günleri arasında ve yaşamın 0 ila 84. günleri arasında hesaplanmıştır. Neonatal dönemde ishalli ve FAS tanılı ve postneonatal dönemde pnömonili kuzuların büyüme performansı (BW ve ADG) aynı dönemdeki sağlıklı kuzulara göre önemli ölçüde düşük bulundu (P<0.05). Doğumdan sonraki 24. saatte serum IgG konsantrasyonu (SIgGC-24) <600 mg/dL ve <1000 mg/ml olan kuzuların canlı ağırlıkları 28. ve 84. günlerde SIgGC-24 >600 mg/dL ve >1000 mg/ml olan kuzulardan önemli ölçüde daha düşüktü (P <0.001). Benzer şekilde, SIgGC-24 <600 mg/dL ve <1000 mg/ml olan kuzu-ların günlük canlı ağırlık artışının 0-28, 29-84 ve 0-84 yaş günlerinde SIgGC-24 >600 mg/dL ve >1000 mg/ml olan kuzulardan önemli ölçüde daha düşüktü (P<0.001). Sonuç olarak, bulgularımız düşük serum IgG konsantrasyonunu ile birlikte pnömoni, ishal ve FAS bulunması kuzularda sütten kesim öncesi büyüme performansını azaltmaktadır.

Keywords

Büyüme performansı, IgG eşik değerleri, kuzu, sağlık

Relationship Between Growth Performance, Passive Immunity and Health In Preweaned Lambs

Abstract

This study was designed to investigate associations between transfer of passive immunity, selected illness-es (diarrhoea, pneumonia, and fatigue anorexia syndrome-FAS) and growth performance [body weight (BW) and aver-age daily gain (ADG)] in preweaned lambs. A total of 347 lambs were blood sampled at 24±1 h of age after birth and the serum IgG concentration for each lamb was measured after colostrum intake using a commercial ELISA kit. Lambs were weighed on a scale immediately after birth (before colostrum intake) and reweighed on day 28 (end of neonatal period) and day 84 (age of weaning). Lambs ADG was calculated from 0 to 28 d of life, from 29 to 84d of life, and from 0 to 84 d of life. Growth performance (BW and ADG) of lambs with diarrhoea and FAS in the neonatal period and with pneumonia in the postneonatal period was significantly lower than that of healthy lambs of the same period (P<0.05). BW of lambs with serum IgG concentration at 24th hour after the birth (SIgGC-24)<600 mg/dL and <1000 mg/ml was significantly lower on days 28 and 84 than that of lambs with SIgGC-24 >600 mg/dL and >1000 mg/ml (P<0.001). Simi-larly, the ADG of lambs with SIgGC-24 <600 mg/dL and <1000 mg/ml was significantly lower on days from 0-28, 29-84 and 0-84 of age than those of lambs with SIgGC-24 >600 mg/dL and >1000 mg/ml (P<0.001). In conclusion, our find-ings show that low serum IgG concentration in lambs, as well as the presence of pneumonia, diarrhea and FAS, reduc-es growth performance in pre-weaning lambs.

Keywords

Growth, health, IgG cut off, lambs, performance

References

• Agenbag B, Swinbourne AM, Petrovski K, van Wet-tere WH. Lambs need colostrum: A review. Livest Sci 2021; 251: 104624.
• Ahmadi M, Boldura O, Milovanov C, Dronca D, Mircu C, Hutu I, Tulcan C. 2016. Colostrum from different animal species-A product for health status enhancement. Bulletin UASVM Anim Sci Biotech 2016; 73(1): 2016.
• Ali MAE, Sayed-Ahmed ME. Relationship between passive immunity levels and morbidity, mortality and growth rates of friesian calves in Egypt. J Anim Poult Prod 2020; 11(12): 629-36.
• Alves AC, Alves NG, Ascari IJ, Junqueira FB, Coutinho AS, Lima RR, Abreu LR. Colostrum com-position of Santa Inês sheep and passive transfer of immunity to lambs. J Dairy Sci 2015; 98(6): 3706-16.
• Andrés S, Jiménez A, Sánchez J, Alonso JM, Gómez L, Lopez F, Rey J. Evaluation of some etiological factors predisposing to diarrhoea in lambs in “La Serena” (Southwest Spain). Small Rum Res 2007; 70(2-3): 272-5.
• Atkinson DJ, Von Keyserlingk MAG, Weary DM. Benchmarking passive transfer of immunity and growth in dairy calves. J Dairy Sci 2017; 100(5): 3773-82.
• Aydogdu U, Coskun A, Yuksel M, Basbug O, Agaoglu ZT. The effect of dystocia on passive immune status, oxidative stress, venous blood gas and acid-base balance in lambs. Small Rum Res 2018; 166: 115-20.
• Bond C. Evaluation of lamb colostrum supplements. Vet Rec 2020; 187(11): e100.
• Britti D, Massimini G, Peli A, Luciani A, Boari A. Evaluation of serum enzyme activities as predictors of passive transfer status in lambs. J Am Vet Med Assoc 2005; 226(6): 951-5.
• Caldow GL, White DG, Kelsey M, Peters AR, Solly KJ. Relationship of calf antibody status to disease and performance. Vet Rec 1988; 122(3): 63-5.
• Elsohaby I, Cameron M, Elmoslemany A, McClure J, Keefe G. Effect of passive transfer of immunity on growth performance of preweaned dairy calves. Can J Vet Res 2019; 83(2): 90-6.
• Gascoigne E, Davies P. An approach to neonatal lamb post-mortem examinations. Livestock 2019; 24(4): 193-8.
• Gilbert RP, Gaskins CT, Hillers JK, Parker CF, McGuire TC. Genetic and environmental factors affecting immunoglobulin G1 concentrations in ewe colostrum and lamb serum. J Anim Sci 1988; 66(4): 855-63.
• Gokce E, Atakisi O, Kirmizigul AH, Unver A, Erdogan HM. Passive immunity in lambs: Serum lactoferrin concentrations as a predictor of IgG concentration and its relation to health status from birth to 12 weeks of life. Small Rum Res 2014; 116(2-3): 219-28.
• Gokce E, Erdogan HM. An epidemiological study on neonatal lamb health. Kafkas Univ Vet Fak Derg 2009; 15(2): 225-36.
• Gokce E, Kirmizigul AH, Atakisi O, Kuru M, Erdogan HM. Passive immunity in lambs: Colostral and se-rum γ-glutamyltransferase as a predictor of IgG concentration and related to the diseases from birth to 12 weeks of life. Vet Med 2021a; 66(2): 45-57.
• Gökçe E, Atakişi O, Kırmızıgül AH, Erdoğan HM. Risk factors associated with passive immunity, health, birth weight and growth performance in lambs: II. Effects of passive immunity and some risk factors on growth performance during the first 12 weeks of life. Kafkas Univ Vet Fak Derg 2013; 19(4): 619-27.
• Gökçe E, Atakişi O, Kırmızıgül AH, Erdogan HM. Interrelationships of serum and colostral IgG (passive immunity) with total protein concentration-sand health in lambs. Kafkas Univ Vet Fak Derg 2019; 25(3): 387-96.
• Gökçe E, Cihan P, Atakişi E, Kırmızıgül AH, Erdoğan HM. Oxidative stress in neonatal lambs and its rela-tion to health status and passive colostral immunity. Vet Immunol Immunopathol 2022; 251: 110470.
• Gökçe E, Sözmen M, Gülmez C, Bozukluhan B, Gökce G, Atakişi E, Erdoğan HM. Carnitine concentrations in healthy and septicaemia suspected neonatal calves and its relation to passive immunty. Turk J Vet Anim Sci 2021b; 45(2): 229-37.
• Hedegaard CJ, Heegaard PM. Passive immunisation, an old idea revisited: basic principles and application to modern animal production systems. Vet Im-munol Immunopathol 2016; 174: 50-63.
• Hernández-Castellano LE, Almeida AM, Ventosa M, Coelho AV, Castro N, Argüello A. The effect of colostrum intake on blood plasma proteome profile in newborn lambs: Low abundance proteins. BMC Vet Res 2014; 10(1):1-9.
• Herndon CN, Shanthalingam S, Knowles DP, Call DR, Srikumaran S. Comparison of passively transferred antibodies in bighorn and domestic lambs reveals one factor in differential susceptibility of these species to Mannheimia haemolytica-induced pneumonia. Clin Vaccine Immun 2011; 18(7): 1133-8.
• Johnson T, Jacobson BT, Jones, K, Mosdal C, Jones S, Vitkovic M, Bimczok D. Transfer and persistence of bovine immunoglobulins in lambs fed a colostrum replacer. Vet Rec 2022; 191(10): 1974.
• Kenyon PR, Roca Fraga FJ, Blumer S, Thompson AN. Triplet lambs and their dams–a review of current knowledge and management systems. New Zealand J Agric Res 2019; 62(4): 399-437.
• Kozyr VS, Antonenko PP, Mylostyvyi RV, Suslova NI, Skliarov PM, Reshetnychenko OP, Pushkar TD, Sapronova VO, Pokhyl OM. Effect of herbal feed additives on the quality of colostrum, immunological indicators of newborn calves blood and growth energy of young animals. Theor Appl Vet Med 2019; 7(3): 137-42.
• Massimini G, Mastellone V, Britti D, Lombardi P, Av-allone L. Effect of passive transfer status on preweaning growth performance in dairy goat kids. J Am Vet Med Assoc 2007; 231(12): 1873-7.
• Massimini G, Britti D, Peli A, Cinotti S. Effect of passive transfer status on preweaning growth performance in dairy lambs. J Am Vet Med Assoc 2006; 229(1): 111-5.
• Mastellone V, Massimini G, Pero ME, Cortese L, Pi-antedosi D, Lombardi P, Avallone L. Effects of passive transfer status on growth performance in buffalo calves. Asian-Australas J Anim Sci 2011; 24(7): 952-6.
• Nocek JE, Braund DG, Warner RG. Influence of neo-natal colostrum administration, immunoglobulin, and continued feeding of colostrum on calf gain, health, and serum protein. J Dairy Sci 1984; 67(2): 319-33.
• Pesca C, Forti K, Felici A, Scoccia E, Forte C, An-tenucci P, Crotti S. Enzootic pneumonia in sheep: ewe and lamb immune response after Mannheimia haemolytica vaccine administration under field condition in Italy. Large Anim Rev 2020; 26(2): 73-6.
• Santiago MR, Fagundes GB, do Nascimento DM, Faustino LR, da Silva CMG, Dias FEF, Cavalcante TV. Use of digital Brix refractometer to estimate total protein levels in Santa Inês ewes’ colostrum and lambs’ blood serum. Small Rum Res 2020; 182: 78-80.
• Tsiligianni T, Dovolou E, Amiridis GS. Efficacy of feeding cow colostrum to newborn lambs. Livestock Sci 2012; 149(3): 305-9.
• Turquino CF, Flaiban KKM, Lisbôa JAN. Transferên-cia de imunidade passiva em cordeiros de corte manejados extensivamente em clima tropical. Pesqui Vet Bras 2011; 31(3): 199-205.
• Vatankhah, M. Relationship between immunoglobulin concentrations in the ewe’s serum and colostrum, and lamb’s serum in Lori-Bakhtiari sheep, Iran. J Appl Anim Sci 2013; 3(3): 539-44.
• Windeyer MC, Leslie KE, Godden SM, Hodgins DC, Lissemore KD, LeBlanc SJ. Factors associated with morbidity, mortality, and growth of dairy heifer calves up to 3 months of age. Prev Vet Med 2014; 113(2): 2.