Rotavirus Enfeksiyonunun Moleküler Patogenezi

Year 2019, , 60 - 67, 25.03.2019

Zeynep Akkutay Yoldar

https://doi.org/10.32707/ercivet.537997

Cited By: 1

Abstract

Rotaviruslar çocuklar ve birçok hayvan türünün yeni doğanlarında ishalin en önemli nedenlerindendir. Çevre şartlarında uzun süre değişmeden kalabilen virusun gıda ve su ile de yayılması mümkündür. Ağız yoluyla organizmaya giren virus; ince bağırsak epitellerinde çoğalarak saçılımını gerçekleştirir ve ishale yol açar. Virusun çoğalması ve viral patogenez konularında yapılan araştırmalar virus ile mücadelede araştırmacılara ışık tutmaktadır. Bu derleme rotavirus enfeksiyonunun moleküler patogenezi hakkında genel bilgi verilmesi amacıyla hazırlanmıştır.

Keywords

Patogenez, replikasyon, rotavirus

References

• 1. Alkan F, Gulyaz V, Timurkan MO, Iyisan S, Ozdemir S, Turan N, Buonavoglia C, Martella V. A large outbreak of enteritis in goat flocks in Marmara, Turkey, by G8P [1] group A rotaviruses. Arch Virol 2012; 157(6):1183-7. 2. Alkan F, Ozkul A, Oguzoglu TC, Timurkan MO, Caliskan E, Martella V, Burgu I. Distribution of G (VP7) and P (VP4) genotypes of group A bovine rotaviruses from Turkish calves with diarrhea, 1997-2008. Vet Microbiol 2010; 141(3): 231-7. 3. Aoki,ST, Settembre EC, Trask SD, Greenberg HB, Harrison SC, Dormitzer PR. Structure of rotavirus outer-layer protein VP7 bound with a neutralizing Fab. Science 2009; 324(5933), 1444-7. 4. Arias CF, Dector MA, Segovia L, López T, Camacho M, Isa P, Espinosa R, López S. RNA silencing of rotavirus gene expression. Virus Res 2004; 102(1): 43-51. 5. Baker TS, Olson NH, Fuller SD. Adding the third dimension to virus life cycles: Three-dimensional reconstruction of icosahedral viruses from cryo-electron micrographs. Microbiol Mol Biol R 1999; 63(4): 862-922. 6. Ball JM, Tian P, Zeng CQ, Morris AP, Estes MK. Age-dependent diarrhea induced by a rotaviral nonstructural glycoprotein. Science 1996; 272(5258): 101-4. 7. Banda K, Kang G, Varki A. 'Sialidase sensitivity' of rotaviruses revisited. Nat Chem Biol 2009; 5(2): 71. 8. Barro M, Patton JT. Rotavirus nonstructural protein 1 subverts innate immune response by inducing degradation of IFN regulatory factor 3. PNAS 2005; 102(11): 4114-9. 9. Berois M, Sapin C, Erk I, Poncet D, Cohen J. Rotavirus nonstructural protein NSP5 interacts with major core protein VP2. J Virol 2003; 77(3): 1757-63. 10. Blackhall J, Munoz M, Fuentes A, Magnusson G. Analysis of rotavirus nonstructural protein NSP5 phosphorylation. J Virol 1998; 72(8): 6398-405. 11. Blutt SE, Fenaux M, Warfield KL, Greenberg HB, Conner ME. Active viremia in rotavirus-infected mice. J Virol 2006; 80(13): 6702-5. 12. Boudreaux CE, Vile DC, Gilmore BL, Tanner JR, Kelly DF, McDonald SM. Rotavirus core shell subdomains involved in polymerase encapsidation into virus-like particles. J Gen Virol 2013; 94(8): 1818-26. 13. Cabral-Romero C, Padilla-Noriega L. Association of rotavirus viroplasms with microtubules through NSP2 and NSP5. Mem I Oswaldo Cruz 2006; 101(6): 603-11. 14. Ciarlet M, Crawford SE, Estes MK. Differential infection of polarized epithelial cell lines by sialic acid-dependent and sialic acid-independent rotavirus strains. J Virol 2001; 75(23): 11834-50. 15. Crawford SE, Mukherjee SK, Estes MK, Lawton JA, Shaw AL, Ramig RF, Prasad BV. Trypsin cleavage stabilizes the rotavirus VP4 spike. J Virol 2001; 75(13): 6052-61. 16. Desselberger U. Rotaviruses. Virus Res 2014; 190: 75-96. 17. Dickey M, Jamison L, Michaud L, Care M, Bernstein DI, Staat MA. Rotavirus meningoencephalitis in a previously healthy child and a review of the literature. Pediatr Infect Dis 2009; 28(4): 318-21. 18. Dóró R, László B, Martella V, Leshem E, Gentsch J, Parashar U, Bányai K. Review of global rotavirus strain prevalence data from six years post vaccine licensure surveillance: Is there evidence of strain selection from vaccine pressure? Infect Genet Evol 2014; 28: 446-61. 19. Dormitzer PR, Sun ZY, Wagner G, Harrison SC. The rhesus rotavirus VP4 sialic acid binding domain has a galectin fold with a novel carbohydrate binding site. EMBO J 2002; 21(5): 885-97. 20. Estes MK, Cohen JE. Rotavirus gene structure and function. Microbiol Rev 1989; 53(4): 410-49. 21. Estes M, Kapikian A. Rotaviruses. Knipe DM. Howley PM. Griffin DE. Lamb RA. Martin MA. Roizman B. Straus SE. eds. In: Fields virology. Fourth Edition. Philadelphia: Kluwer/Lippincott, Williams and Wilkins, 2007; pp.1917-74. 22. Estes MK, Greenberg HB. Rotaviruses. Knipe DM. Howley PM. Cohen JI. Griffin DE. Lamb R. Martin MA. Racaniello VR. Roizman B. eds. In: Fields Virology. Sixth Edition Philadelphia: Wolters Kluwer Health/Lippincott Williams and Wilkins, 2013; pp.1347-401. 23. Ge Y, Mansell A, Ussher JE, Brooks AE, Manning K, Wang CJ, Taylor JA. Rotavirus NSP4 triggers secretion of proinflammatory cytokines from macrophages via toll-like receptor 2. J Virol 2013; 87(20): 11160-7. 24. Graff JW, Mitzel DN, Weisend CM, Flenniken ML, Hardy ME. Interferon regulatory factor 3 is a cellular partner of rotavirus NSP1. J Virol 2002; 76(18): 9545-50. 25. González AM, Azevedo MS, Saif LJ. Intestinal and systemic immunity to rotavirus in animal models and humans. Vajdy M. ed. In: Immunity Against Mucosal Pathogens. Dordrecht: Springer, 2008; pp. 263-97. 26. Harb M, Becker MM, Vitour D, Baron CH, Vende P, Brown SC, Bolte S, Arold ST, Poncet D. Nuclear localization of cytoplasmic poly (A)-binding protein upon rotavirus infection involves the interaction of NSP3 with eIF4G and RoXaN. J Virol 2008; 82(22): 11283-93. 27. Hirsch AJ. The use of RNAi-based screens to identify host proteins involved in viral replication. Future Microbiol 2010; 5(2): 303-11. 28. Hu L, Chow DC, Patton JT, Palzkill T, Estes MK, Prasad BV. Crystallographic analysis of rotavirus NSP2-RNA complex reveals specific recognition of 5′ GG sequence for RTPase activity. J Virol 2012; 86(19): 10547-57. 29. Hyser JM, Collinson-Pautz MR, Utama B, Estes MK. Rotavirus disrupts calcium homeostasis by NSP4 viroporin activity. MBio 2010; 1(5): e00265-10. 30. Jayaram H, Estes MK, Prasad BV. Emerging themes in rotavirus cell entry, genome organization, transcription and replication. Virus Res 2004; 101(1): 67-81. 31. Jayaram H, Taraporewala Z, Patton JT, Prasad BV. Rotavirus protein involved in genome replication and packaging exhibits a HIT-like fold. Nature 2002; 417(6886): 311. 32. Jones S. A brush with rotavirus. Nat Rev Microbiol 2006; 4(12): 877-8. 33. Karol S, Suludere Z, Ayvalı C. Biyoloji Terimleri Sözlüğü. Beşinci Baskı. Ankara: TDK Yayınları, 2010; s. 306. 34. Karayel I, Fehér E, Marton S, Coskun N, Bányai K, Alkan F. Putative vaccine breakthrough event associated with heterotypic rotavirus infection in newborn calves, Turkey, 2015. Vet Microbiol 2017; 201: 7-13. 35. Kumar M, Jayaram H, Vasquez-Del Carpio R, Jiang X, Taraporewala ZF, Jacobson RH, Patton JT, Prasad BV. Crystallographic and biochemical analysis of rotavirus NSP2 with nucleotides reveals a nucleoside diphosphate kinase-like activity. J Virol 2007; 81(22): 12272-84. 36. Lawton JA, Estes MK, Prasad BV. Three-dimensional visualization of mRNA release from actively transcribing rotavirus particles. Nat Struct Mol Biol 1997; 4(2): 118. 37. López T, Camacho M, Zayas M, Nájera R, Sánchez R, Arias CF, López S. Silencing the morphogenesis of rotavirus. J Virol 2005; 79(1): 184-92. 38. Lorrot M, Vasseur M. How do the rotavirus NSP4 and bacterial enterotoxins lead differently to diarrhea? Virol J 2007; 4(1): 31. 39. Ludert JE, Michelangeli F, Gil F, Liprandi F, Esparza J. Penetration and uncoating of rotaviruses in cultured cells. Intervirology 1987; 27(2): 95-101. 40. Long CP, McDonald SM. Rotavirus genome replication: Some assembly required. PLoS Pathog 2017; 13(4): e1006242. 41. Martella V, Ciarlet M, Baselga R, Arista S, Elia G, Lorusso E, Banyai K, Terio V, Madio A, Ruggeri FM, Falcone E. Sequence analysis of the VP7 and VP4 genes identifies a novel VP7 gene allele of porcine rotaviruses, sharing a common evolutionary origin with human G2 rotaviruses. Virology 2005; 337(1): 111-23. 42. Martella V, Ciarlet M, Banyai K, Lorusso E, Cavalli A, Corrente M, Elia G, Arista S, Camero M, Desario C, Decaro N. Identification of a novel VP4 genotype carried by a serotype G5 porcine rotavirus strain. Virology 2006; 346(2): 301-11. 43. Matthijnssens J, Ciarlet M, McDonald SM, Attoui H, Bányai K, Brister JR, Buesa J, Esona MD, Estes MK, Gentsch JR, Iturriza-Gómara M. Uniformity of rotavirus strain nomenclature proposed by the Rotavirus Classification Working Group (RCWG). Arch Virol 2011; 156(8): 1397-413. 44. Matthijnssens J, Van Ranst M. Genotype constellation and evolution of group A rotaviruses infecting humans. Curr Opin Virol 2012; 2(4): 426-33. 45. McClain B, Settembre E, Temple BR, Bellamy AR, Harrison SC. X-ray crystal structure of the rotavirus inner capsid particle at 3.8 Å resolution. J Mol Biol 2010; 397(2): 587-99. 46. McDonald SM, Patton JT. Assortment and packaging of the segmented rotavirus genome. Trends Microbiol 2011; 19(3): 136-44. 47. Montero H, Arias CF, Lopez S. Rotavirus nonstructural protein NSP3 is not required for viral protein synthesis. J Virol 2006; 80(18): 9031-8. 48. O'brien JA, Taylor JA, Bellamy AR. Probing the structure of rotavirus NSP4: a short sequence at the extreme C terminus mediates binding to the inner capsid particle. J Virol 2000; 74(11): 5388-94. 49. Pesavento JB, Crawford SE, Estes MK, Prasad BV. Rotavirus proteins: Structure and assembly. Roy P. ed. In: Reoviruses: Entry, Assembly and Morphogenesis. Berlin: Springer, 2006; pp. 189-219. 50. Prasad BV, Rothnagel R, Zeng CY, Jakana J, Lawton JA, Chiu W, Estes MK. Visualization of ordered genomic RNA and localization of transcriptional complexes in rotavirus. Nature 1996; 382(6590): 471. 51. Ramig RF. Pathogenesis of intestinal and systemic rotavirus infection. J Virol 2004; 78(19): 10213-20. 52. Reidy N, Lennon G, Fanning S, Power E, O'Shea H. Molecular characterisation and analysis of bovine rotavirus strains circulating in Ireland 2002-2004. Vet Microbiol 2006; 117(2-4): 242-7. 53. Rubio RM, Mora SI, Romero P, Arias CF, López S. Rotavirus prevents the expression of host responses by blocking the nucleocytoplasmic transport of polyadenylated mRNAs. J Virol 2013; 87(11): 6336-45. 54. Sastri NP, Crawford SE, Estes MK. Pleiotropic properties of rotavirus nonstructural protein 4 (NSP4) and their effects on viral replication and pathogenesis. Svensson L. Desselberger U. Estes M. Greenberg H. eds. In: Viral Gastroenteritis. Oxford: Academic Press Elsevier, 2016; pp.145-74. 55. Settembre EC, Chen JZ, Dormitzer PR, Grigorieff N, Harrison SC. Atomic model of an infectious rotavirus particle. EMBO J 2011; 30(2): 408-16. 56. Silvestri LS, Taraporewala ZF, Patton JT. Rotavirus replication: plus-sense templates for double-stranded RNA synthesis are made in viroplasms. J Virol 2004; 78(14): 7763-74. 57. Taraporewala ZF, Kumar M, Prasad BV, Patton JT. Structure and function of the rotavirus NSP2 octamer, an essential component of the viroplasm. Patton JT. ed. In: Segmented Double-Stranded Rna Viruses: Structure and Molecular Biology. Norfolk: Caister Academic Press, 2008; pp. 273-89. 58. Trask SD, Ogden KM, Patton JT. Interactions among capsid proteins orchestrate rotavirus particle functions. Curr Opin Virology 2012; 2(4): 373-9. 59. von Sochaczewski CO, Pintelon I, Brouns I, Dreier A, Klemann C, Timmermans JP, Petersen C, Kuebler JF. Rotavirus particles in the extrahepatic bile duct in experimental biliary atresia. J Pediatr Surg 2014; 49(4): 520-4. 60. Vonsover A, Shif IL, Silberstein I, Rudich H, Aboudy YA, Mendelson E, Shulman L, Nakagomi T, Nakagomi O. Identification of feline-and canine-like rotaviruses isolated from humans by restriction fragment length polymorphism assay. J Clin Microbiol 1993; 31(7): 1783-7. 61. Zhang YD, Li H, Liu H, Pan YF. Expression, purification, crystallization and preliminary X-ray diffraction analysis of the VP8* sialic acid-binding domain of porcine rotavirus strain OSU. Acta Crystallogr F 2007; 63(2): 93-5.