Bir Güvercin Sürüsünde Aspergillus fumigatus Enfeksiyonu

Year 2015, Volume: 12 Issue: 2, 147 - 152, 01.08.2015

Öznur Aslan , Duygu Yaman İlknur Karaca Bekdik , Seçil Abay , Görkem Ekebaş

Abstract

Bu çalışma ile yaklaşık 80 güvercinin olduğu bir sürüde A. fumigatus enfeksiyonu klinik, mikrobiyolojik ve
histopatolojik olarak belirlendi. Güvercinlerde klinik olarak iştahsızlık, zayıflama, yeşil sulu ishal, kusma, halsizlik,
solunum güçlüğü, seromüköz burun akıntısı ve ölüm belirlendi. Ölen güvercinlerin nekropsi muayenesinde
akciğer lobları üzerinde çok sayıda toplu iğne başı büyüklüğünde sarımsı-gri renkli nodüller gözlendi. Nodüllerde
Aspergillus’un karakteristik hifaları belirlendi ve kültürün mikrobiyolojik muayenesinde Aspergillus fumigatus olduğu
tanımlandı. Tedavi amacıyla içme sularına 15 gün ara ile üç gün nistatin, (Mikostatin® oral süspansiyon
100.000 IU/ml, Bristol-Myers squibb) 500.000 IU/L dozunda uygulandığında klinik bulguların düzeldiği belirlendi.

Keywords

Aspergillus fumigatus, güvercin, nistatin

Aspergillus fumigatus Infection in a Pigeon Flock

Abstract

In this study, Aspergillus fumigatus infection in a flock of near 80 pigeons, was described in terms
of clinical, microbiological and histopathological aspects. At the clinical examinations were determined inappetance,
green watery diarrhea, vomiting, weakness, lethargy, dyspnea, seromucous discharge from nostrils and
death. The lungs showed multiple pinhead- size yellowish to grayish nodules at the necropsy examinations of
pigeons. Histology demonstrated hyphae characteristic of Aspergillus was recovered as Aspergillus fumigatus in
microbiological examination of culture. The clinical symptoms have been observed to improve by adding nystatin
(Mikostatin® oral suspension 100.000 IU/ml, Bristol-Myers squibb) to drinking water at 500.000 IU/L doses, twice
in 15 days except for 3 days.

Keywords

Aspergillus fumigatus, nystatin, pigeon

References

• 1. Abrams GA, Paul-Murphy J, Ramer JC, Murphy CJ. Aspergillus blepharitis and dermatitis in a peregrine falcon-gyrfalcon hybrid (Falco peregrinus x Falco rusticolus). J Avian Med Surg 2001; 15(2): 114-20.
• 2. Arné P, Thierry S, Wang D, Deville M, Le Loc’h G, Desoutter A, Féménia F, Nieguitsila A, Huang W, Chermette R, Guillot J. Aspergillus fumigatus in poultry. Int J Microbiol 2011; 2011:746356, Published online Jun 14, 2011. doi: 10.1155/2011/746356.
• 3. Barton JT, Daft BM, Read DH, Kinde H, Bickford AA. Tracheal aspergillosis in 6 1/2-week-old chickens caused by Aspergillus flavus. Avian Dis 1992; 36(4): 1081-5.
• 4. Bauck L, Hillyer A, Hoefer H. Rhinitis: Case reports. The Annual Conference of the Association of Avian Veterinarians. September, 134, 1992; New Orleans-USA.
• 5. Beernaert LA, Pasmans F, Haesebrouck F, Martel A. Modelling Aspergillus fumigatus infections in racing pigeons (Columba livia domestica). Avian Pathol 2008; 37(5): 545-9.
• 6. Beernaert LA, Frank Pasmans F, Baert K, Van Waeyenberghe L, Chiers K, Haesebrouck F, Martel A. Designing a treatment protocol with voriconazole to eliminate Aspergillus fumigatus from experimentally inoculated pigeons. Vet Microbiol 2009; 139(3-4): 393-7.
• 7. Beernaert LA, Pasmans F, Van Waeyenberghe L, Haesebrouck F, Martel A. Aspergillus infections in birds: A review. Avian Pathol 2010; 39(5): 325-31.
• 8. Carrasco L, Lima Jr JS, Halfen DC, Salguero FJ, Sanchez-Cordon P, Becker G. Systemic Aspergillosis in an oiled Magallanic penguin (Spheniscus magellanicus). J Vet Med B Infect Dis Vet Public Health 2001; 48(7): 551-4.
• 9. Forbes NA. Aspergillosis in raptors. Vet Rec 1991; 128(11): 263.
• 10. Gümüşsoy KS, Uyanik F, Atasever A, Çam Y. Experimental Aspergillus fumigatus infection in quails and results of treatment with itraconazole. J Vet Med 2004; 51(1): 34-8.
• 11. Hadrich I, Drira I, Neji S, Mahfoud N, Ranque S, Makni F, Ayadi A. Microsatellite typing of Aspergillus flavus from clinical and environmental avian isolates. J Med Microbiol 2013; 62(1): 121-5.
• 12. Hernandez-Divers SJ. Endosurgical debridement and diode laser ablation of lung and air sac granulomas in psittacine birds. J Avian Med Surg 2002; 16(2):138-45.
• 13. İçen H, Işık N, Yeşilmen S, Tuzcu M, Sekin S. Diagnosis and treatment of aspergillosis in an ostrich flock. Kafkas Univ Vet Fak Derg 2011; 17(4): 671-4.
• 14. Jones MP, Orosz SE. The diagnosis of aspergillosis in birds. Semin Avian Exot Pet 2000; 9(2): 52-8.
• 15. Jones MP, Orosz SE, Cox SK, Frazier DL. Pharmacokinetic disposition of itraconazole in red-tailed hawks (Buteo jamaicensis). J Avian Med Surg 2000; 14(1): 15-22.
• 16. Jung K, Kim Y, Lee H, Kim JT. Aspergillus fumigatus infection in two wild Eurasian black vultures (Aegypius monachus Linnaeus) with carbofuran insecticide poisoning: A case report. Vet J 2009; 179(2):307-32.
• 17. Kelly TR, Vennen KM, Duncan R, Sleeman JM. Lymphoproliferative disorder in a great horned owl (Bubo virginianus). J Avian Med Surg 2004; 18(4): 263-8.
• 18. Keskin O, Çimtay İ. Devekuşlarında aspergillozisin tedavisinde ketokonazolun etkinliğinin araştırılması. Vet Hekim Mikrobiyol Derg 2002; 2(2): 27-30.
• 19. Khosravi AR, Shokri H, Ziglari T, Naeini AR, Mousavi Z, Hashemi H. Outbreak of severe disseminated aspergillosis in a flock of ostrich (Struthio camelus). Mycoses 2008; 51(6): 557-9.
• 20. Kurtdede A. Kafes Kuşlarının Muayenesi ve Hastalıkları. Genişletilmiş İkinci Baskı. Ankara: Azim Matbaacılık, 2002; p.88.
• 21. Low M, Berggen A, Morgan KJ, Alley MR. Aspergillosis in a North Island robin (Petroica longipes). New Zeal Vet J 2005; 53(6): 462-4.
• 22. Luna LG, ed. Manual of Histologic Staining Methods of The Armed Forces Institute of Pathology. Third Edition. New York: Blakiston Division, McGraw-Hill,1968; p.229.
• 23. McMillan MC, Petrak ML. Retrospective study of aspergillosis in pet birds. J Avian Med Surg 1989; 3(4): 211-5.
• 24. Oglesbee BL. Mycotic diseases. Altman RB ed. In: Avian Medicine and Surgery First Edition. Philadelphia: PA: WB Saunders Company,1997; pp. 323-61.
• 25. Phalen DN. Respiratory medicine of cage and aviary birds. Vet Clin North Am Exot Anim Pract 2000; 3(2): 423-52.
• 26. Raczyński E, Kempski W. Aspergillosis of ornamental and wild birds in 1986-1995. Med Weter 1997; 53: 153-5.
• 27. Reihill JA, Moore JE, Elborn JS, Ennis M. Effect of Aspergillus fumigatus and Candida albicans on pro-inflammatory response in cystic fibrosis epithelium. J Cyst Fibros 2011; 10(6): 401-6.
• 28. Reissig EC, Uzal FA, Schettino A, Robles CA. Pulmonary aspergillosis in a great rhea (Rhea americana). Avian Dis 2002; 46(3): 754-6.
• 29. Rochette F, Engelen M, Bossche HV. Antifungal agents of use in animal health practical applications. J Vet Pharmacol Ther 2003; 26(1): 31-53.
• 30. Soike D, Köhler B, Albrecht K. A circovirus-like infection in geese related to a runting syndrome. Avian Pathol 1999; 28(2): 199-202.
• 31. Stone WB, Okoniewski JC. Necropsy findings and environmental contaminants in common loons from New York. J Wildl Dis 2001; 37(1): 178-84.
• 32. Suleiman MM, Duncan N, Eloff JN, Naidoo V. A controlled study to determine the efficacy of Loxostylis alata (Anacardiaceae) in the treatment of aspergillus in a chicken (Gallus domesticus) model in comparison to ketoconazole. Vet Res 2012; 8: 210-9.
• 33. Tell LA. Aspergillosis in mammals and birds: Impact on veterinary medicine. Med Mycol 2005; 43(1): 71-3.
• 34. Tokarzewski S, Ziolkowska G, Lopuszynski W, Nozdryn-Plotnicki Z. Aspergillus fumigatus infection in a pigeon flock. Bull Vet Inst Pulawy 2007; 51: 563-7.
• 35. Tsai SS, Park JH, Hirai K, Itakura C. Aspergillosis and candidiasis in psittacine and passeriforme birds with particular reference to nasal lesions. Avian Pathol 1992; 21(4): 699-709.
• 36. Westerhof I. Treatment of tracheal obstruction in psittacine birds using a suction technique: A retrospective study of 19 birds. J Avian Mede Surg 1995; 9(1): 45-9.
• 37. Vanden Bossche H, Engelen M, Rochette F. Antifungal agents of use in animal health - chemical, biochemical and pharmacological aspects. J Vet Pharmacol Therap 2003; 26(1): 5-29.
• 38. Vanderheyden N. Aspergillosis in psittacine chicks. Annual Conference, Association of Avian Veterinarians. August 31-September 4, 1993; Nashville, Tennessee, USA.
• 39. Verstappen FALM, Dorrestein GM. Aspergillosis in Amazon parrots after corticosteroid therapy for smoke-inhalation injury. J Avian Med Surg 2005; 19(2): 138-41.
• 40. Young EA, Cornish TE, Little SE. Concomitant mycotic and verminous pneumonia in a Blue Jay from Georgia. J Wildl Dis 1998; 34(3): 625-8.