Kitosan-Gümüş Nanopartikülü ve Kitosan-Gümüş-Grafen Oksit Nanokompozitinin Sentezi, Karakterizasyonu ve Antimikrobiyal Aktivitelerinin Belirlenmesi

Year 2018, Volume: 15 Issue: 3, 208 - 215, 04.12.2018

Dilşad Onbaşlı

https://doi.org/10.32707/ercivet.477291

Abstract

Mikrobiyal patojenlerde antibiyotik dirençliliği dünyada ciddi bir sağlık sorunu haline gelmiştir. Son yıllarda, anti-mikrobiyal aktiviteye sahip yeni bileşikler geliştirmek için daha etkili alternatif tedavi yaklaşımları araştırılmaktadır. Na-nopartiküller (NP) sahip oldukları üstün özellikler nedeniyle, antibakteriyel etki, kanser terapisi, ilaç ve gen taşıyıcı sis-temler gibi birçok alanda uygulama bulmaktadır. Bu çalışmada, hidrotermal yöntemle sentezlenen yeni nesil bir anti-mikrobiyal ajan olarak kitosan-gümüş nanopartükülü (K-Ag-NP) ve kitosan-Gümüş-Grafen Oksit (K-Ag-GO) nanokom-poziti (NK) kullanılmıştır. Bu maddeler UV-visible (UV-vis) absorpsiyon spektroskopisi ve taramalı elektron mikroskobu (SEM) ile karakterize edilmiştir. Aynı zamanda bu maddelerin Escherichia coli ATCC 35218, Staphylococcus aureus ATCC 25923, Streptococcus. mutans ATCC 68175, Bacillus subtilis ATCC 6633, Candida albicans ATCC 90028 suşla-rına karşı antimikrobiyal aktiviteleri disk difüzyon tekniği kullanılarak araştırılmıştır. Elde ettiğimiz veriler bu maddelerin antibakteriyel etkiye sahip olduğunu göstermiştir.

Keywords

Antimikrobiyal aktivite, grafen oksit nanokompoziti, gümüş nanopartikülü, kitosan

References

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