Bisfenol A İçerikli Rezin Esaslı Dental Materyallerde Bisfenol A Salınımı ve İnsan Vücuduna Östrojenik Etkilerinin İncelenmesi

Year 2021, , 109 - 121, 30.12.2021

Sena Gürsoy , Ebru Emekli Alturfan

https://doi.org/10.29228/erd.14

Abstract

Dünyada her yıl 5 milyon tonu aşkın üretim kapasitesiyle en çok kullanılan ürün olan Bisfenol A, endokrin bozucu kimyasallar arasında yer almaktadır. Dayanıklı yapısıyla plastikler, gıda saklama kapları, plastik su şişeleri, elektronik cihazlar, metal konserve ve içecek kutularının iç yüzey kaplamaları, bebek biberonları, diş hekimliğinde kullanılan dolgu malzemeleri ve çürükten koruma amacıyla yaygın kullanılan fissür örtücüler gibi çok çeşitli ve yaygın alanda karşımıza çıkmaktadır. Geniş bir yelpazede kullanım alanına sahip olan Bisfenol A, canlılarda ksenoöstrojen olarak etki göstermektedir. Diş hekimliğinde kullanılan bazı materyaller, hava, su, toprak, besinler gibi çeşitli kaynaklardan Bisfenol A ile maruziyet söz konusudur ve bu maruziyetler sonucu vücutta toksik etkiler görülebilmektedir. Bisfenol A ile maruziyetle meydana gelebilecek etkilerin önemli bir halk sağlığı problemi olduğu düşünülmekte ve bu konuda yapılan çalışmalar her geçen gün artmaktadır.
Bu derlemede Bisfenol A’nın yapısı, insan vücudundaki yazgısıyla beraber doz bağımlı östrojenik etkileri, diş hekimliğinde kullanılan kompozit restoratif dolgu materyali ve fissür örtücülerindeki yeri ile Bisfenol A sızıntılarının östrojenik etkileri arasındaki bağlantı incelenmiştir. İncelenen çalışmalar net bir kanıda buluşmasa da, dental tedavilerde kompozit ve fissür örtücü uygulanması ile Bisfenol A ile maruziyet söz konusu olabileceği ve uzun dönemde sağlık üzerine olumsuz etkileri olabileceği ortaya konmuştur.

Keywords

Bisfenol A, kompozit, fissür örtücü, östrojen

Bisphenol A Release in Resin-Based Dental Materials Containing Bisphenol A and Investigation of Estrogenic Effects on Human Body

Abstract

Bisphenol A, which is the most used product in the world with a production capacity of more than 5 million tons every year, is among the endocrine disrupting chemicals. With its durable structure, plastics, food storage containers, plastic water bottles, electronic devices, inner surface coatings of metal can and beverage cans, baby bottles, filling materials used in dentistry and fissure sealants that are widely used for decay protection, are encountered in a wide range of and widespread areas. Bisphenol A has a wide range of uses and acts as a xenoestrogen. There are several exposure routes of Bisphenol A from various sources such as some materials used in dentistry, air, water, soil and nutrients and toxic effects can be seen in the body as a result of these exposures. These effects are considered to be an important public health problem, and studies on this subject are increasing day by day.
In this review, the structure of Bisphenol A, its dose-dependent estrogenic effects along with its fate in the human body, its place in composite restorative filling materials and fissure sealants used in dentistry, and the relationship between the estrogenic effects of Bisphenol A leaks were investigated. Although the studies examined do not meet a clear conclusion, it has been revealed that the application of composite and fissure sealant in dental treatments may lead to Bisphenol A exposure and may have negative effects on health in the long term.

Keywords

bisphenol a, composite, fissure sealant, estrogen

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