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İMMÜNONÜTRİSYON VE KANSER

Year 2019, Volume: 6 Issue: 1, 93 - 101, 15.06.2019

Abstract

İmmün sistemi daha etkin kılmak amacıyla arjinin, glutamin, n-3 yağ asitleri ve nükleotitler gibi çeşitli besin öğeleri ile zenginleştirilerek uygulanan beslenme şekline immünonütrisyon adı verilmektedir. Onkolojik hastalara uygulanan immünonütrisyon desteği; cerrahi sonrası morbiditeyi, enfeksiyöz komplikasyon oranlarını, yara gelişimini ve hastanede yatış süresini azaltmaktadır. İmmün sistemin diyetle güçlendirilmesi kanser hastalarında önemli bir ek tedavi olarak kabul edilmeye başlanmıştır. Bu derlemede; onkoloji hastalarında önemli rolleri olan immünonütrientler ve bu besin öğelerinin etkileri hakkında literatür bilgisi doğrultusunda bilgi vermek amaçlanmaktadır.

References

  • Arends J, Bodoky G, Bozzetti F, et al. ESPEN guidelines on enteral nutrition: non-surgical oncology. Clin Nutr 2006; 25 (2): 245-259.
  • Arends J, Bachmann P, Baracos V, et al. ESPEN guidelines on nutrition in cancer patients. Clin Nutr 2016; 36 (1): 1-38.
  • August D, Huhmann MB. ASPEN clinical guidelines: Nutrition support therapy during adult anticancer treatment and in hematopoietic cell transplantation. J Parenter Enteral Nutr 2009; 33 (5): 472-500.
  • Barış N, Turgan N, Ersöz B. Argininin tıpsal biyokimyadaki önemi. Türk Klinik Biyokimya Derg 2004; 2 (2): 83-90.
  • Braga M, Gianotti L, Nespoli L, et al. Nutritional approach in malnourished surgical patients. Arch Surg 2002; 137 (2): 174-180.
  • Braga M, GianottiL, Radaelli G, et al. Perioperative immünonutrition in patients undergoing cancer surgery. Arch Surg 1999;134 (4): 428-433.
  • Chasapis C, Loutsidou AC, Spiliopoulou CA, et al. Zinc and human health. Arch Toxicol 2012; 86 (4): 521-534.
  • Chattopadhyay S, Saha A, Azam M, et al. Role of oral glutamine in alleviation and prevention of radiation-induced oral mucositis: A prospective randomized study. South Asian J Cancer 2014; 3 (1): 8-12.
  • Coşkun T. İmmünonütrisyondan farmakonütrisyona. Çocuk Sağlığı ve Hastalıkları Dergisi 2011; 54: 164-181.
  • Çoker A. İmmünonütrisyon. Yoğun Bakım Derneği Dergisi 2006; 4 (1): 40-44.
  • Fairweather-Tait S, Bao Y, Broadley MR, et al. Selenium in human health and disease. Antioxid Redox Signal 2011; 14 (7): 1337- 1383.
  • Farreras N, Artigas V, Cardona D, et al. Effect of early postoperative enteral immunonutrition on wound healing in patients undergoing surgery for gastric cancer. Clin Nutr 2005; 24 (1): 55-65.
  • Federico A, Iodice P, Federico P, et al. Effects of selenium and zinc supplementation on nutritional status in patients with cancer of digestive tract. Eur J Clin Nutr 2001; 55 (4): 293- 297.
  • Grimble R. Nutritional modulation of immune function. Proc Nutr Soc 2001; 60 (3): 389- 397.
  • Hoang B, Han B, Shaw DG, et al. Zinc as a possible preventive and therapeutic agent in pancreatic, prostate, and breast cancer. Eur J Cancer Prev 2016; 25 (5): 457-461.
  • Kanekiyo S, Takeda S, Iida M, et al. Efficacy of perioperative immunonutrition in esophageal cancer patients undergoing esophagectomy. Nutrition 2019; 59: 96-102.
  • Levis S, Pugsley M, Schneider C, et al. The effect of immünonutrition on veterans undergoing major surgery for gastrointestinal cancer. Fed Pract 2018; 35(Suppl 4): 49–S56.
  • Lın L, Que J, Lın LK, et al. Zinc supplementatıon to improve mucositis and dermatitis in patients after radıotherapy for head-and-neck cancers: a double-blind, randomized study. Int J Radiation Oncology Biol Phys 2006; 65 (3): 745-750.
  • Luis D, Izaola O, Aller R, et al. A randomized clinical trial with oral immunonutrition (ω3- enhanced formula vs. arginine-enhanced formula) in ambulatory head and neck cancer patients. Ann Nutr Metab 2005; 49 (2) :95-99.
  • May P, Barber A, D'Olimpio JT, et al. Reversal of cancer-related wasting using oral supplementation with a combination of β-hydroxy- β-methylbutyrate, arginine, and glutamine. Am J Surg 2002; 183 (4): 471-479.
  • Öztürk E. Kanser ve immünonütrisyon. İç Hastalıkları Dergisi 2010; 17 : 239-246.
  • Öztürk M. Preoperatif Alanin-Glutaminden Zenginleştirilmiş Diyetin Elektif Kolon Anastomozu Üzerine Etkileri (Deneysel Çalışma). Uzmanlık Tezi, Dr.Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi, İstanbul, 2004: 51.
  • Prieto I, Montemuino S, Luna J, et al. The role of immunonutritional support in cancer treatment: Current evidence. Clin Nutr 2017; 36 (6): 1457-1464.
  • Rajagopalan K, DeBerardinis RJ. Role of glutamine in cancer: Therapeutic and imaging implications. J Nucl Med 2011; 52 (7): 1005-1008.
  • Rayman M. Selenium and human health. Lancet 2012; 379 : 1256-1268.
  • Riso S, Aluffi P, Brugnani M, et al. Postoperative enteral immunonutrition in head and neck cancer patients. Clin Nutr 2000; 19 (6): 407- 412.
  • Suchner U, Kuhn KS, Fürst P. The scientific basis of immunonutrition. Proc Nutr Soc 2000; 59 (4): 553-563.
  • Tokatlı A. İmmünonütrisyon. Ankem Dergi 2002; 16 (3): 390-394.
  • Vidal-Casariego A, Calleja-Fernández A, Ballesteros-Pomar MD, et al. Efficacy of glutamine in the prevention of oral mucositis and acute radiation-induced esophagitis: A retrospective study. Nutr Cancer 2013; 65 (3) : 424-429.
  • Wu X, Tang J, Xie M. Serum and hair zinc levels in breast cancer: A meta-analysis. Sci Rep 2015; 5: 1-8.
  • Xu J, Zhong Y, Jing D, et al. Preoperative enteral immunonutrition improves postoperative outcome in patients with gastrointestinal cancer. World J Surg 2006; 30 (7): 1284- 1289.
  • Yıldırım Z, Bidev D, Büyükavcı M. Parenteral glutamine supplementation has no effect on chemotherapy-induced toxicity in children with non-hodgkin lymphoma. Am J Pediatr Hematol Oncol 2013; 35 (5): 371-376.
  • Yoshida S, Kaibara A, Ishibashi N. Glutamine supplementation in cancer patients. Nutrition 2001; 17 (9): 766-768.
  • Zhang Y, Gu Y, Guo T, et al. Perioperative immunonutrition for gastrointestinal cancer: A systematic review of randomized controlled trials. Surg Oncol 2012; 21 (2): 87-95.
  • Zheng G, Zheng Z, Zhao Y, et al. Clinical application of glutamine enhanced hypo-nitrogen hypo-caloric parenteral nutrition in postoperative stress period for gastric cancer patients with nutritional risk. Progress in Modern Biomedicine 2013: 13.
  • Ziegler T. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001; 131 (9): 2578-2584.
  • Ziegler T. Glutamine supplementation in bone marrow transplantation (BMT). Br J Nutr 2002; 87 (1): 9-15.
Year 2019, Volume: 6 Issue: 1, 93 - 101, 15.06.2019

Abstract

References

  • Arends J, Bodoky G, Bozzetti F, et al. ESPEN guidelines on enteral nutrition: non-surgical oncology. Clin Nutr 2006; 25 (2): 245-259.
  • Arends J, Bachmann P, Baracos V, et al. ESPEN guidelines on nutrition in cancer patients. Clin Nutr 2016; 36 (1): 1-38.
  • August D, Huhmann MB. ASPEN clinical guidelines: Nutrition support therapy during adult anticancer treatment and in hematopoietic cell transplantation. J Parenter Enteral Nutr 2009; 33 (5): 472-500.
  • Barış N, Turgan N, Ersöz B. Argininin tıpsal biyokimyadaki önemi. Türk Klinik Biyokimya Derg 2004; 2 (2): 83-90.
  • Braga M, Gianotti L, Nespoli L, et al. Nutritional approach in malnourished surgical patients. Arch Surg 2002; 137 (2): 174-180.
  • Braga M, GianottiL, Radaelli G, et al. Perioperative immünonutrition in patients undergoing cancer surgery. Arch Surg 1999;134 (4): 428-433.
  • Chasapis C, Loutsidou AC, Spiliopoulou CA, et al. Zinc and human health. Arch Toxicol 2012; 86 (4): 521-534.
  • Chattopadhyay S, Saha A, Azam M, et al. Role of oral glutamine in alleviation and prevention of radiation-induced oral mucositis: A prospective randomized study. South Asian J Cancer 2014; 3 (1): 8-12.
  • Coşkun T. İmmünonütrisyondan farmakonütrisyona. Çocuk Sağlığı ve Hastalıkları Dergisi 2011; 54: 164-181.
  • Çoker A. İmmünonütrisyon. Yoğun Bakım Derneği Dergisi 2006; 4 (1): 40-44.
  • Fairweather-Tait S, Bao Y, Broadley MR, et al. Selenium in human health and disease. Antioxid Redox Signal 2011; 14 (7): 1337- 1383.
  • Farreras N, Artigas V, Cardona D, et al. Effect of early postoperative enteral immunonutrition on wound healing in patients undergoing surgery for gastric cancer. Clin Nutr 2005; 24 (1): 55-65.
  • Federico A, Iodice P, Federico P, et al. Effects of selenium and zinc supplementation on nutritional status in patients with cancer of digestive tract. Eur J Clin Nutr 2001; 55 (4): 293- 297.
  • Grimble R. Nutritional modulation of immune function. Proc Nutr Soc 2001; 60 (3): 389- 397.
  • Hoang B, Han B, Shaw DG, et al. Zinc as a possible preventive and therapeutic agent in pancreatic, prostate, and breast cancer. Eur J Cancer Prev 2016; 25 (5): 457-461.
  • Kanekiyo S, Takeda S, Iida M, et al. Efficacy of perioperative immunonutrition in esophageal cancer patients undergoing esophagectomy. Nutrition 2019; 59: 96-102.
  • Levis S, Pugsley M, Schneider C, et al. The effect of immünonutrition on veterans undergoing major surgery for gastrointestinal cancer. Fed Pract 2018; 35(Suppl 4): 49–S56.
  • Lın L, Que J, Lın LK, et al. Zinc supplementatıon to improve mucositis and dermatitis in patients after radıotherapy for head-and-neck cancers: a double-blind, randomized study. Int J Radiation Oncology Biol Phys 2006; 65 (3): 745-750.
  • Luis D, Izaola O, Aller R, et al. A randomized clinical trial with oral immunonutrition (ω3- enhanced formula vs. arginine-enhanced formula) in ambulatory head and neck cancer patients. Ann Nutr Metab 2005; 49 (2) :95-99.
  • May P, Barber A, D'Olimpio JT, et al. Reversal of cancer-related wasting using oral supplementation with a combination of β-hydroxy- β-methylbutyrate, arginine, and glutamine. Am J Surg 2002; 183 (4): 471-479.
  • Öztürk E. Kanser ve immünonütrisyon. İç Hastalıkları Dergisi 2010; 17 : 239-246.
  • Öztürk M. Preoperatif Alanin-Glutaminden Zenginleştirilmiş Diyetin Elektif Kolon Anastomozu Üzerine Etkileri (Deneysel Çalışma). Uzmanlık Tezi, Dr.Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi, İstanbul, 2004: 51.
  • Prieto I, Montemuino S, Luna J, et al. The role of immunonutritional support in cancer treatment: Current evidence. Clin Nutr 2017; 36 (6): 1457-1464.
  • Rajagopalan K, DeBerardinis RJ. Role of glutamine in cancer: Therapeutic and imaging implications. J Nucl Med 2011; 52 (7): 1005-1008.
  • Rayman M. Selenium and human health. Lancet 2012; 379 : 1256-1268.
  • Riso S, Aluffi P, Brugnani M, et al. Postoperative enteral immunonutrition in head and neck cancer patients. Clin Nutr 2000; 19 (6): 407- 412.
  • Suchner U, Kuhn KS, Fürst P. The scientific basis of immunonutrition. Proc Nutr Soc 2000; 59 (4): 553-563.
  • Tokatlı A. İmmünonütrisyon. Ankem Dergi 2002; 16 (3): 390-394.
  • Vidal-Casariego A, Calleja-Fernández A, Ballesteros-Pomar MD, et al. Efficacy of glutamine in the prevention of oral mucositis and acute radiation-induced esophagitis: A retrospective study. Nutr Cancer 2013; 65 (3) : 424-429.
  • Wu X, Tang J, Xie M. Serum and hair zinc levels in breast cancer: A meta-analysis. Sci Rep 2015; 5: 1-8.
  • Xu J, Zhong Y, Jing D, et al. Preoperative enteral immunonutrition improves postoperative outcome in patients with gastrointestinal cancer. World J Surg 2006; 30 (7): 1284- 1289.
  • Yıldırım Z, Bidev D, Büyükavcı M. Parenteral glutamine supplementation has no effect on chemotherapy-induced toxicity in children with non-hodgkin lymphoma. Am J Pediatr Hematol Oncol 2013; 35 (5): 371-376.
  • Yoshida S, Kaibara A, Ishibashi N. Glutamine supplementation in cancer patients. Nutrition 2001; 17 (9): 766-768.
  • Zhang Y, Gu Y, Guo T, et al. Perioperative immunonutrition for gastrointestinal cancer: A systematic review of randomized controlled trials. Surg Oncol 2012; 21 (2): 87-95.
  • Zheng G, Zheng Z, Zhao Y, et al. Clinical application of glutamine enhanced hypo-nitrogen hypo-caloric parenteral nutrition in postoperative stress period for gastric cancer patients with nutritional risk. Progress in Modern Biomedicine 2013: 13.
  • Ziegler T. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001; 131 (9): 2578-2584.
  • Ziegler T. Glutamine supplementation in bone marrow transplantation (BMT). Br J Nutr 2002; 87 (1): 9-15.
There are 37 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Derleme Bölümü
Authors

Sema Çalapkorur

Gamze Akbulut

Publication Date June 15, 2019
Submission Date December 5, 2019
Published in Issue Year 2019 Volume: 6 Issue: 1

Cite

APA Çalapkorur, S., & Akbulut, G. (2019). İMMÜNONÜTRİSYON VE KANSER. ERÜ Sağlık Bilimleri Fakültesi Dergisi, 6(1), 93-101.