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Year 2020, Volume: 7 Issue: 2, 49 - 54, 16.01.2021

Fulden Ulucan-karnak

Abstract

Multiple sclerosis is a central nervous system disease that occurs when the immune system tries to destroy the myelin sheath surrounding nerve cells for defense purposes. Many different methods are used for its diagnosis and it takes a long time to confirm the diagnosis. Although there are clinically approved drugs for treatment for the disease, none of them alone is totally successful and sufficient. Various studies are carried out in which physiotherapy and stem cell therapies are used alone or in combination to increase the success of treatment and the quality of life of patients. In this review, it is aimed to share the treatment approaches used against multiple sclerosis disease.

Keywords

multiple sclerosis therapy approaches stem cell

References

  • 1. Zalc B. One hundred and fifty years ago Charcot reported multiple sclerosis as a new neurological disease. Brain. 2018;141(12):3482–8. doi: 10.1093/brain/awy287
  • 2. Steinman L. Multiple sclerosis: A coordinated immunological attack against myelin in the central nervous system. Cell. 1996;85(3):299–302. doi: 10.1016/s0092-8674(00)81107-1
  • 3. Loma I, Heyman R. Multiple Sclerosis: Pathogenesis and Treatment. Curr Neuropharmacol [Internet]. 2011;9(3):409–16. doi: 10.2174/157015911796557911
  • 4. Thompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee T, Comi G, et al. Position Paper Diagnosis of multiple sclerosis: 2018 Feb;17(2):162-173. doi: 10.1016/S1474-4422(17)30470-2.
  • 5. Omerhoca S, Yazici Akkas S, Kale Icen N. Multiple sclerosis: Diagnosis and Differrential Diagnosis. Arch Neuropsychiatry. 2018;(Supplement 1):1–9. doi : 10.29399/npa.23418
  • 6. Ghasemi N, Razavi S, Nikzad E. Multiple Sclerosis: Pathogenesis, Symptoms, Diagnoses and Cell-Based Therapy. Cell J. 2017;19(191):1–10. doi: 10.22074/cellj.2016.4867
  • 7. Alghwiri AA, Jamali F, Aldughmi M, Khalil H, Al-Sharman A, Alhattab D, et al. The effect of stem cell therapy and comprehensive physical therapy in motor and non-motor symptoms in patients with multiple sclerosis. Medicine (Baltimore). 2020;99(34):e21646. doi: 10.1097/MD.0000000000021646
  • 8. Tintore M, Vidal-Jordana A, Sastre-Garriga J. Treatment of multiple sclerosis — success from bench to bedside. Nat Rev Neurol . 2019;15(1):53–8. doi:10.1038/s41582-018-0082-z
  • 9. Gholamzad M, Ebtekar M, Ardestani MS, Azimi M, Mahmodi Z, Mousavi MJ, et al. A comprehensive review on the treatment approaches of multiple sclerosis: currently and in the future. Inflamm Res . 2019;68(1):25–38. doi:10.1007/s00011-018-1185-0
  • 10. Delmendo, I., Pigeon, T., Ceffret, M., K., Szeszko, A., Potash J. Current Strategies in the Treatment of Multiple Sclerosis. AJMC Perspect [Internet]. 2018;3–12. Available at: www.ajmc.com
  • 11. Gajofatto A, Benedetti MD. Treatment strategies for multiple sclerosis: When to start, when to change, when to stop? World J Clin Cases . 2015 ;3(7):545. doi: 10.12998/wjcc.v3.i7.545
  • 12. Genc B, Bozan HR, Genc S, Genc K. Stem Cell Therapy for Multiple Sclerosis. Advances in Experimental Medicine and Biology. Springer New York LLC; 2019. 1084; s. 145–174. doi:10.1007/5584_2018_247
  • 13. Cuascut FX, Hutton GJ. Stem cell-based therapies for multiple sclerosis: Current perspectives. Biomedicines. 2019;7(2):26. doi: 10.3390/biomedicines7020026
  • 14. Martino G, Franklin RJM, Van Evercooren AB, Kerr DA. Stem cell transplantation in multiple sclerosis: Current status and future prospects , Nature Reviews Neurology. Nature Publishing Group; 2010 . s. 247–55. doi: 10.1038/nrneurol.2010.35
  • 15. Figueroa FE, Carrión F, Villanueva S, Khoury M. Mesenchymal Stem Cell treatment for autoimmune diseases: A critical review. Biol Res. 2012;45(3):269–77. doi: 10.4067/S0716-97602012000300008
  • 16. Muraro PA, Martin R, Mancardi GL, Nicholas R, Sormani MP, Saccardi R. Autologous haematopoietic stem cell transplantation for treatment of multiple sclerosis. C. 13, Nature Reviews Neurology. Nature Publishing Group; 2017. s. 391–405. doi: 10.1038/nrneurol.2017.81
  • 17. Soleimani M, Aghayan HR, Goodarzi P, Hagh MF, Lajimi AA, Saki N, et al. Stem cell therapy ‒Approach for multiple sclerosis treatment. Arch Neurosci. 2016;3(1):1–9. doi:10.5812/archneurosci.21564
  • 18. Llufriu S, Sepúlveda M, Blanco Y, Marín P, Moreno B, Berenguer J, et al. Randomized placebo-controlled phase II trial of autologous mesenchymal stem cells in multiple sclerosis. PLoS One. 2014;9(12):1–15. doi:10.1371/journal.pone.0113936
  • 19. Mancardi GL, Sormani MP, Gualandi F, Saiz A, Carreras E, Merelli E, et al. Autologous hematopoietic stem cell transplantation in multiple sclerosis: A phase II trial. Neurology .2015;84(10):981–8. doi:10.1212/WNL.0000000000001329
  • 20. Muraro PA, Pasquini M, Atkins HL, Bowen JD, Farge D, Fassas A, et al. Long-term outcomes after autologous hematopoietic stem cell transplantation for multiple sclerosis. JAMA Neurol. 2017;74(4):459–69. doi: 10.1001/jamaneurol.2016.5867
  • 21. Shroff G. Transplantation of human embryonic stem cells in patients with multiple sclerosis and lyme disease. Am J Case Rep. 2016;17:944–9. doi:10.12659/AJCR.899745
  • 22. Pluchino S, Smith JA, Peruzzotti-Jametti L. Promises and Limitations of Neural Stem Cell Therapies for Progressive Multiple Sclerosis. Trends Mol Med . 2020;xx(xx):1–15. doi:10.1016/j.molmed.2020.04.005
  • 23. Döring A, Pfueller CF, Paul F, Dörr J. Exercise in multiple sclerosis -- an integral component of disease management. EPMA J . 2012;3(1):2. doi: 10.1007/s13167-011-0136-4
  • 24. Alphonsus KB, Su Y, D’Arcy C. The effect of exercise, yoga and physiotherapy on the quality of life of people with multiple sclerosis: Systematic review and meta-analysis. Complement Ther Med. 2019;43:188–95. doi:10.1016/j.ctim.2019.02.010

MULTIPL SKLEROZ HASTALIĞINA KARŞI TEDAVİ YAKLAŞIMLARI

Year 2020, Volume: 7 Issue: 2, 49 - 54, 16.01.2021

Fulden Ulucan-karnak

Abstract

Multiple skleroz, bağışıklık sisteminin savunma amaçlı olarak sinir hücrelerini çevreleyen miyelin kılıfı yok etmeye çalışması ile ortaya çıkan bir merkezi sinir sistemi hastalığıdır. Teşhisi için çok farklı metotlar kullanılmakta ve tanıyı kesinleştirmek uzun zaman almaktadır. Hastalığın tedavisinde ise klinik onaylı ilaçlar olmasına rağmen hiç biri tek başına tamamen başarılı ve yeterli değildir. Tedavi başarısını ve hastaların yaşam kalitesini arttırmak için fizyoterapi ve kök hücre tedavilerinin tek başına ya da birlikte kullanıldığı çok çeşitli araştırmalar yürütülmektedir. Bu derlemede multiple skleroz hastalığına karşı uygulanan tedavi yaklaşımlarının paylaşılması amaçlanmıştır.

Keywords

Multipl Skleroz Tedavi Yaklaşımları Kök Hücre

References

  • 1. Zalc B. One hundred and fifty years ago Charcot reported multiple sclerosis as a new neurological disease. Brain. 2018;141(12):3482–8. doi: 10.1093/brain/awy287
  • 2. Steinman L. Multiple sclerosis: A coordinated immunological attack against myelin in the central nervous system. Cell. 1996;85(3):299–302. doi: 10.1016/s0092-8674(00)81107-1
  • 3. Loma I, Heyman R. Multiple Sclerosis: Pathogenesis and Treatment. Curr Neuropharmacol [Internet]. 2011;9(3):409–16. doi: 10.2174/157015911796557911
  • 4. Thompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee T, Comi G, et al. Position Paper Diagnosis of multiple sclerosis: 2018 Feb;17(2):162-173. doi: 10.1016/S1474-4422(17)30470-2.
  • 5. Omerhoca S, Yazici Akkas S, Kale Icen N. Multiple sclerosis: Diagnosis and Differrential Diagnosis. Arch Neuropsychiatry. 2018;(Supplement 1):1–9. doi : 10.29399/npa.23418
  • 6. Ghasemi N, Razavi S, Nikzad E. Multiple Sclerosis: Pathogenesis, Symptoms, Diagnoses and Cell-Based Therapy. Cell J. 2017;19(191):1–10. doi: 10.22074/cellj.2016.4867
  • 7. Alghwiri AA, Jamali F, Aldughmi M, Khalil H, Al-Sharman A, Alhattab D, et al. The effect of stem cell therapy and comprehensive physical therapy in motor and non-motor symptoms in patients with multiple sclerosis. Medicine (Baltimore). 2020;99(34):e21646. doi: 10.1097/MD.0000000000021646
  • 8. Tintore M, Vidal-Jordana A, Sastre-Garriga J. Treatment of multiple sclerosis — success from bench to bedside. Nat Rev Neurol . 2019;15(1):53–8. doi:10.1038/s41582-018-0082-z
  • 9. Gholamzad M, Ebtekar M, Ardestani MS, Azimi M, Mahmodi Z, Mousavi MJ, et al. A comprehensive review on the treatment approaches of multiple sclerosis: currently and in the future. Inflamm Res . 2019;68(1):25–38. doi:10.1007/s00011-018-1185-0
  • 10. Delmendo, I., Pigeon, T., Ceffret, M., K., Szeszko, A., Potash J. Current Strategies in the Treatment of Multiple Sclerosis. AJMC Perspect [Internet]. 2018;3–12. Available at: www.ajmc.com
  • 11. Gajofatto A, Benedetti MD. Treatment strategies for multiple sclerosis: When to start, when to change, when to stop? World J Clin Cases . 2015 ;3(7):545. doi: 10.12998/wjcc.v3.i7.545
  • 12. Genc B, Bozan HR, Genc S, Genc K. Stem Cell Therapy for Multiple Sclerosis. Advances in Experimental Medicine and Biology. Springer New York LLC; 2019. 1084; s. 145–174. doi:10.1007/5584_2018_247
  • 13. Cuascut FX, Hutton GJ. Stem cell-based therapies for multiple sclerosis: Current perspectives. Biomedicines. 2019;7(2):26. doi: 10.3390/biomedicines7020026
  • 14. Martino G, Franklin RJM, Van Evercooren AB, Kerr DA. Stem cell transplantation in multiple sclerosis: Current status and future prospects , Nature Reviews Neurology. Nature Publishing Group; 2010 . s. 247–55. doi: 10.1038/nrneurol.2010.35
  • 15. Figueroa FE, Carrión F, Villanueva S, Khoury M. Mesenchymal Stem Cell treatment for autoimmune diseases: A critical review. Biol Res. 2012;45(3):269–77. doi: 10.4067/S0716-97602012000300008
  • 16. Muraro PA, Martin R, Mancardi GL, Nicholas R, Sormani MP, Saccardi R. Autologous haematopoietic stem cell transplantation for treatment of multiple sclerosis. C. 13, Nature Reviews Neurology. Nature Publishing Group; 2017. s. 391–405. doi: 10.1038/nrneurol.2017.81
  • 17. Soleimani M, Aghayan HR, Goodarzi P, Hagh MF, Lajimi AA, Saki N, et al. Stem cell therapy ‒Approach for multiple sclerosis treatment. Arch Neurosci. 2016;3(1):1–9. doi:10.5812/archneurosci.21564
  • 18. Llufriu S, Sepúlveda M, Blanco Y, Marín P, Moreno B, Berenguer J, et al. Randomized placebo-controlled phase II trial of autologous mesenchymal stem cells in multiple sclerosis. PLoS One. 2014;9(12):1–15. doi:10.1371/journal.pone.0113936
  • 19. Mancardi GL, Sormani MP, Gualandi F, Saiz A, Carreras E, Merelli E, et al. Autologous hematopoietic stem cell transplantation in multiple sclerosis: A phase II trial. Neurology .2015;84(10):981–8. doi:10.1212/WNL.0000000000001329
  • 20. Muraro PA, Pasquini M, Atkins HL, Bowen JD, Farge D, Fassas A, et al. Long-term outcomes after autologous hematopoietic stem cell transplantation for multiple sclerosis. JAMA Neurol. 2017;74(4):459–69. doi: 10.1001/jamaneurol.2016.5867
  • 21. Shroff G. Transplantation of human embryonic stem cells in patients with multiple sclerosis and lyme disease. Am J Case Rep. 2016;17:944–9. doi:10.12659/AJCR.899745
  • 22. Pluchino S, Smith JA, Peruzzotti-Jametti L. Promises and Limitations of Neural Stem Cell Therapies for Progressive Multiple Sclerosis. Trends Mol Med . 2020;xx(xx):1–15. doi:10.1016/j.molmed.2020.04.005
  • 23. Döring A, Pfueller CF, Paul F, Dörr J. Exercise in multiple sclerosis -- an integral component of disease management. EPMA J . 2012;3(1):2. doi: 10.1007/s13167-011-0136-4
  • 24. Alphonsus KB, Su Y, D’Arcy C. The effect of exercise, yoga and physiotherapy on the quality of life of people with multiple sclerosis: Systematic review and meta-analysis. Complement Ther Med. 2019;43:188–95. doi:10.1016/j.ctim.2019.02.010
There are 24 citations in total.

Details

Primary Language Turkish
Subjects Clinical Sciences
Journal Section Derleme Bölümü
Authors

Fulden Ulucan-karnak 0000-0001-5567-0261

Publication Date January 16, 2021
Submission Date November 3, 2020
Published in Issue Year 2020 Volume: 7 Issue: 2

Cite

APA Ulucan-karnak, F. (2021). MULTIPL SKLEROZ HASTALIĞINA KARŞI TEDAVİ YAKLAŞIMLARI. ERÜ Sağlık Bilimleri Fakültesi Dergisi, 7(2), 49-54.