Cytotoxic Activity Evaluation of Three New Metal Complexes

Year 2021, Volume: 14 Issue: 1, 306 - 313, 31.03.2021

Halime Güzin Aslan , Senem Akkoç , Zülbiye Kökbudak

https://doi.org/10.18185/erzifbed.875774

Abstract

Salisilaldehit ve 1-amino-5-(4-metilbenzoil)-4-p-tolilpirimidin-2(1H)-on bir Schiff bazı olan 1-(2-hidroksibenzilidenamino)-5-(4-metilbenzoil)-4-p-tolilpirimidin-2 (1H)-on (S1) 'u hazırlamak için kullanıldı. Üç yeni kompleks (Ag (I), Pd (II) ve Pt (II)) bu şelat ligandından (S1) sentezlendi. Metal kompleksleri insan kolon kanser hücre hattına karşı tarandı ve gümüş kompleksinin, kullanılan standart ilaçtan daha fazla sitotoksik aktiviteye sahip olduğu bulundu.

Keywords

Cytotoxic activity, Metal complexes, Schiff base

Supporting Institution

Erciyes Üniversitesi

Project Number

FBA-2013-4659

Thanks

The authors are grateful to Erciyes University’s Research Foundation (FBA-2013-4659) for financial support.

Yeni Metal Komplekslerinin Sentezi ve Sitotoksik Aktivite Değerlendirmesi

Abstract

Salisilaldehit ve 1-amino-5-(4-metilbenzoil)-4-p-tolilpirimidin-2(1H)-on bir Schiff bazı olan 1-(2-hidroksibenzilidenamino)-5-(4-metilbenzoil)-4-p-tolilpirimidin-2(1H)-on (S1) 'u hazırlamak için kullanıldı. Üç yeni kompleks (Ag(I), Pd(II) ve Pt(II)) bu şelat ligantdan (S1) sentezlendi. Ag(I) kompleksi insan kolon kanser hücre hattına karşı tarandı ve gümüş kompleksinin kullanılan standart ilaçtan daha fazla sitotoksik aktiviteye sahip olduğu bulundu.

Keywords

sitotoksik aktivite, kanser, metal kompleksleri, schiff bazı

Project Number

FBA-2013-4659

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