The Maternal, Cord Blood and Neonatal Serum Ischemia-Modified Albumin Levels in Different Modes of Delivery

Year 2023, , 35 - 40, 04.07.2023

Dilek Ulubas Isik , Sezin Unal , Nihal Demirel , Yıldız Akdaş Reis , Özcan Erel , Ahmet Yağmur Baş

https://doi.org/10.46969/EZH.1313284

Abstract

Background: Human serum albumin modifies in response to ischemic events and affinity of N-terminal decreases for metal especially for cobalt. This modification results in the formation of ischemia modified albumin (IMA). The IMA rises immediately after ischemic event and remains high for several hours after cessation of ischemia. The purpose of this study was to investigate the effects of mode of delivery on the IMA levels in mothers and their term infants, and to determine which mode causes much oxidative stress.
Study Design: The cases were grouped according to the mode of delivery: vaginal delivery group (VD, n=40) and cesarean group (C/S, n=40). The serum samples were collected from mothers before delivery (pre-delivery), from the cord blood (CB) and from the infants at the 24th hour after birth according to the following criteria: (1) singleton live birth, (2) gestational age between 37- 41 6/7 weeks, (3) birth weight of 2500 and 4000 g, and (4) Apgar scores ≥ 8 at 5 min. The IMA levels of both groups were compared.
Results: The pre-delivery serum IMA levels were similar between two groups. The cord blood IMA levels were significantly higher in C/S group than those with VD group (0.694±0.113 vs 0.642±0.084, p=0.021). The serum IMA levels were higher in infants born by C/S compared with those born by VD, but the result was not statistically significant.
Conclusion: Our results showed the IMA levels in infants and cord blood was influenced by the way of delivery and supported that oxidative stress is reduced in vaginally delivered infants.

Keywords

Cord blood, Ischemia modified albumin, Mode of delivery, Newborn

Farklı Doğum Şekillerinde Anne, Kordon Kanı ve Yenidoğanda Serum İskemi-Modifiye Albümin Düzeyleri

Abstract

Amaç: Serum albumini iskemik olaylara yanıt olarak değişir ve N-terminalinin kobalt metaline afinitesi azalır. Bu modifikasyon sonucu iskemi modifiye albümin (IMA) oluşur. IMA, iskemik olaydan hemen sonra yükselir ve iskeminin sonlanmasından sonra birkaç saat yüksek kalır. Bu çalışmanın amacı, doğum şeklinin annelerde ve term bebeklerde İMA düzeylerine etkisini araştırmak ve hangi doğum şeklinin daha fazla oksidatif strese neden olduğunu belirlemektir.
Gereç ve Yöntem: Vakalar doğum şekline göre vajinal doğum grubu (VD, n=40) ve sezaryen grubu (C/S, n=40) olarak gruplandırıldı. Annelerden doğum öncesi, kordon kanından ve bebeklerden doğumdan sonraki 24. saatte serum örnekleri belirlenen kriterlere uyan vakalardan alındı; (1) tekil canlı doğum, (2) gebelik yaşı 37-41 6/7 hafta arası, (3) 2500 ve 4000 gr doğum ağırlığı ve (4) 5. dakikada Apgar skoru ≥ 8. Her iki grubun İMA düzeyleri karşılaştırıldı.
Bulgular: Doğum öncesi serum IMA seviyeleri iki grup arasında benzerdi. Kordon kanı IMA düzeyleri C/S grubunda VD grubuna göre anlamlı olarak yüksekti (0,694±0,113’e vs 0,642±0,084, p=0,021). C/S ile doğan bebeklerde serum IMA seviyeleri, VD ile doğan bebeklere göre daha yüksekti, ancak sonuç istatistiksel olarak anlamlı değildi.
Sonuç: Bulgularımız bebeklerde ve kord kanında IMA düzeylerinin doğum şeklinden etkilenebileceğini ve VD ile doğan bebeklerde oksidatif stresin azaldığını desteklemektedir.

Keywords

İskemi modifiye albumin, Doğum şekli, Kord kanı, Yenidoğan

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