İntrauterin İnseminasyon Uygulanan Hastalarda Sperm Parametrelerinin Gebelik Sonuçları ile İlişkisi

Year 2021, , 60 - 66, 30.09.2021

Cuma Taşın , Gülnur Özakşit

https://doi.org/10.46969/ezh.962608

Cited By: 1

Abstract

Amaç: İnfertil hastalarda intrauterin inseminasyon yaygın kullanılan bir yöntemdir. Bu hastalardaki gebelik başarısını
etkileyen sperm parametreleri ise hala tartışmalı bir konudur. Bu çalışmamız sperm parametrelerinin intrauterin
inseminasyon sonuçlarına etkisini tayin etmeyi amaçlamaktadır.
Gereç ve Yöntem: Çalışmamız Ocak 2009-Ocak 2011 tarihleri arasında Dr. Zekai Tahir Burak Kadın Sağlığı Eğitim ve Araştırma
Hastanesi infertilite polikliniğinde rekombinant FSH ile ovulasyon indüksiyonu oluşturulup intrauterin inseminasyon
uygulanan 170 infertil hastanın 300 siklusunun incelendiği bir çalışmadır. Yaş, bazal FSH, toplam kullanılan FSH dozu,
tedavi siklus sayısı, sigara kullanımı, varikosel ve semen parametreleri ile tedavi sonuçları karşılaştırıldı. Hastaların semen
parametrelerinde total progresif motil sperm sayısı ≤10 milyon ve >10 milyon , morfoloji ise ≤ % 4 ve >% 4 olarak gruplara
ayrıldı. Total progresif motil sperm sayısı ve morfoloji gruplarının gebelik sonuçlarına bakıldı. Erkek hastalarda sigara
kullanımı ve varikoselin total progresif motil sperm sayısı ve morfolojiye olan etkilerine bakıldı.
Bulgular: Total progresif motil sperm sayısı <10 milyon ve ≥10 milyon grupları arasında ve morfoloji ≤% 4 ve >% 4
grupları arasında klinik gebelik oranları açısından istatiksel olarak anlamlı fark saptanmadı. Erkelerde sigara kullanımının
normal morfolojideki sperm sayısının azalttığı, varikoselin ise hem total progresif motil sperm sayısını hem de normal
morfolojideki sperm sayısının azalttığı bulundu.
Sonuç: İntrauterin inseminasyon sikluslarındaki gebelik oranları ne tek başına morfoloji ne de tek başına total progresif
motil sperm sayısı ile korelasyon göstermektedir. İnfertil erkeklerde sigara kullanımının özellikle morfolojiyi bozarak
gebelik oranlarını azalttığı saptandı. Varikoselin hem morfolojiyi hem de total progresif motil sperm sayısını azalttığı
fakat bunun gebelik sonuçlarını etkilemediği sonucuna ulaşıldı.

Keywords

intrauterin inseminasyon, sperm parametreleri, Total progresif motil sperm sayısı, morfoloji

The Relationship Between Sperm Parameters and Pregnancy Outcomes in Patients Undergoing Intra Uterine Insemination

Abstract

Aim: Intrauterine insemination is a widely used method in infertile patients. Sperm parameters that affect pregnancy
success in these patients are still a problematic issue. This study aims to determine the effect of sperm parameters on
intrauterine insemination results.
Material and Method: In this study; 300 cycles of 170 infertile patients who underwent intrauterine insemination after
ovulation induction with recombinant FSH in the infertility outpatient clinic of the Dr. Zekai Tahir Burak Women's Health
Training and Research Hospital between January 2009 and January 2011 were examined. Age, basal FSH, total FSH
dose used, number of treatment cycles, smoking, varicocele, semen parameters and treatment results were compared.
Patients were divided into groups as Total progressive motile sperm count ≤10 million and >10 million, morphology ≤4%
and morphology >4% in semen parameters. Pregnancy results of total progressive motile sperm count and morphology
groups were analyzed. In male patients, the effects of smoking and varicocele on total progressive motile sperm count
and morphology from sperm parameters were evaluated.
Results: No statistically significant difference was found between the total progressive motile sperm count ≤10 million
and total progressive motile sperm count >10 million groups and between the morphology≤4% and morphology>4%
groups in terms of clinical pregnancy rates. It was found that smoking in men decreased morphology, while varicocele
decreased both total progressive motile sperm count and morphology.
Conclusion: Pregnancy rates in intrauterine insemination cycles show no correlation with either morphology alone or
total progressive motile sperm count alone. It was found that smoking in infertile men decreased pregnancy rates by
particularly disrupting the morphology. It was concluded that varicocele reduces both morphology and total progressive
motile sperm count in male patients, but this does not affect pregnancy outcomes.

Keywords

Intrauterine insemination; sperm parameters; total progressive motile sperm count; morphology

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