Cytotoxic Effects of Biosynthesized zinc nanoparticles on Normal fibroblast cells and their antimicrobial effect on pathogenic strains

Year 2024, Volume: 4 Issue: 2, 108 - 121, 03.10.2024

Dr. Margi Patel , Dr. Farida Minocheherhomji

https://doi.org/10.59838/etoxec.1502126

Abstract

Nanoparticles, particularly zinc nanoparticles (ZnNPs), have garnered substantial interest in biomedical research for their potential applications in therapeutics and antimicrobial therapy. In this study, we investigated the cytotoxic effects of biosynthesized zinc nanoparticles on normal fibroblast cells and evaluated their antimicrobial efficacy against pathogenic strains. The biosynthesis of zinc nanoparticles was achieved through an eco-friendly and cost-effective approach utilizing biological agents. The cytotoxicity of biosynthesized zinc nanoparticles was assessed on normal fibroblast cells, serving as a model for evaluating biocompatibility. Our results indicate that biosynthesized zinc nanoparticles exhibited minimal cytotoxicity towards normal fibroblast cells, suggesting their potential safety for biomedical applications. Furthermore, the antimicrobial activity of biosynthesized zinc nanoparticles was evaluated against pathogenic strains, including antibiotic-resistant bacteria. The antimicrobial efficacy of zinc nanoparticles demonstrated promising results, highlighting their potential as alternative antimicrobial agents. Overall, this study provides valuable insights into the cytotoxic effects of biosynthesized zinc nanoparticles on normal fibroblast cells and underscores their antimicrobial potential against pathogenic strains, offering opportunities for the development of nanoparticle-based therapeutics and antimicrobial agents in medicine and healthcare.

Keywords

Antimicrobial activity, MTT cell viability assay, Scanning Electron Microscopy, Zinc nanoparticles.

Supporting Institution

Drs. Kiran & Pallavi Patel Global University

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