A STUDY ON DIAGNOSTIC AND PROGNOSTIC ROLE OF PERIOSTIN IN RESPIRATORY SYSTEM DISEASE COMPLEX IN CALVES

Year 2024, Volume: 33 Issue: 1, 25 - 34, 01.04.2024

Derviş Baran , İhsan Keleş

https://doi.org/10.34108/eujhs.1367430

Abstract

The purpose of this study was to compare the amounts of serum amyloid a, haptoglobin, fibrinogen, and periostin in calves with respiratory system disease complex before and after treatment. Three groups were used in the study: an acute group (n=10) made up of calves with acute respiratory system disease complex symptoms, a chronic group made up of calves with chronic respiratory system disease complex symptoms, and a control group made up of disease-free, healthy calves. Before and after therapy (day 0, 7 and 14), clinical examinations were performed and blood samples were taken from the acute and chronic groups. Calves in the control group only had one clinical evaluation and blood sample collection. Results showed that both the acute and chronic groups exhibited clinical improvement after treatment. Before treatment, the concentrations of fibrinogen, serum amyloid A, and haptoglobin in the acute and chronic groups were significantly higher than those in the control group (p<0.001). On days 7 and 14, the serum periostin concentrations of the acute group were lower than those of the chronic group and control group (p<0.05). However, no significant difference was observed in serum periostin concentrations before and after treatment in both the acute and chronic groups (p>0.05). Additionally, a positive correlation was found between the respiratory system disease complex scores and the concentrations of serum amyloid A, haptoglobin, and fibrinogen. However, there was no significant correlation between periostin concentrations and respiratory system disease complex scores, as well as between fibrinogen, haptoglobin, and serum amyloid A concentrations (p>0.05).Based on the findings, it can be concluded that haptoglobin, serum amyloid A, and fibrinogen values, rather than periostin, play an important role in supporting the diagnosis and prognosis of respiratory system disease complex in calves.

Keywords

Calves, Diagnostic, Periostin, Prognostic, Respiratory system

Ethical Statement

I declare that this study is my own work and that all information has been obtained in accordance with academic and ethical rules. I also declare that I have fully cited all materials and results as required by academic and ethical rules, and in case the works of others are used, I have cited the relevant works in accordance with scientific rules and shown them in the list of references.

Supporting Institution

This study was produced from Derviş BARAN's doctoral thesis. Additionally, it was supported by Erciyes University Scientific Research Projects Unit with the project code TDK-2018-8422.

Thanks

I would like to thank my thesis advisor Prof. Dr. İhsan KELEŞ, Erciyes University, Faculty of Veterinary Medicine, for his support and help in the planning, execution and writing of this thesis project.

BUZAĞILARDA SOLUNUM SİSTEMİ HASTALIK KOMPLEKSİNDE PERİOSTİNİN DİAGNOSTİK VE PROGNOSTİK ROLÜ ÜZERİNE BİR ÇALIŞMA

Abstract

Bu çalışmada buzağılarda Solunum Sistemi Hastalıkları Kompleks’in de serum amiloidA, haptoglobin, fibrinojen ve periostin konsantrasyonlarının tedavi öncesi ve tedavi sonrası değişimlerinin araştırılması amaçlandı. Çalışmada üç grup kullanılmıştır: Akut solunum sistemi hastalığı kompleksi semptomları olan buzağılardan oluşan bir akut grup (n=10), kronik solunum sistemi hastalığı kompleksi semptomları olan buzağılardan oluşan bir kronik grup ve hastalıksız, sağlıklı buzağılardan oluşan bir kontrol grubu. Tedaviden önce ve sonra (0, 7 ve 14. günler), akut ve kronik gruplardan klinik muayeneler yapıldı ve kan örnekleri alındı. Kontrol grubundaki buzağılardan sadece bir klinik değerlendirme ve kan örneği alınmıştır. Sonuçlar hem akut hem de kronik grupların tedaviden sonra klinik iyileşme gösterdiğini ortaya koymuştur. Tedavi öncesinde, akut ve kronik gruplardaki fibrinojen, serum amiloidA ve haptoglobin konsantrasyonları kontrol grubundakilerden anlamlı derecede yüksekti (p<0.001). 7. ve 14. günlerde, akut grubun serum periostin konsantrasyonları kronik grup ve kontrol grubundan daha düşüktü (p<0.05). Ancak, hem akut hem de kronik gruplarda tedavi öncesi ve sonrası serum periostin konsantrasyonlarında anlamlı bir fark gözlenmemiştir (p>0.05). Ayrıca, solunum sistemi hastalığı kompleksi skorları ile serum amiloidA, haptoglobinve fibrihojen konsantrasyonları arasında pozitif bir korelasyon bulunmuştur. Ancak, periostin konsantrasyonları ile solunum sistemi hastalığı kompleksi skorları arasında ve ayrıca fibrinojen, haptoglobin ve serum amiloidA konsantrasyonları arasında anlamlı bir korelasyon bulunmamıştır (p>0.05).Bulgulara dayanarak, buzağılarda solunum sistemi hastalığı kompleksinin tanı ve prognozunu desteklemede periostin'den ziyade haptoglobin, serum amiloidA ve fibrinojen değerlerinin önemli bir rol oynadığı sonucuna varılabilir.

Keywords

Buzağı, Diagnostik, Periostin, Prognostik, Solunum Sistemi

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