The effect of Arnebia purpurea extract on the survival of random pattern skin flaps in rats

Year 2018, Volume: 4 Issue: 3, 152 - 156, 04.07.2018

Erkan Orhan , Merve Yüzbaşıoğlu Yağmur Reyyan Erol Erem Bilensoy Nazlı Erdoğar Lütfiye Ömür Demirezer , Ayşe Kuruüzüm-uz

https://doi.org/10.18621/eurj.335550

Abstract

Objectives. One of the important causes of flap
losses is ischemia-reperfusion damage. Arnebia species are
rich in naphthoquinone derivatives which known to have anti-inflammatory and anti-oxidant
effects. The aim of the present study was to investigate the effects of Arnebia purpurea extract on viability of
the skin flaps. Methods. Eighteen Wistar rats were divided in three groups. Caudal-based
9×3 cm size skin flap were applied  on
dorsum of the all rats and following surgery, 2 cc of A. purpurea extract topically was applied to the group 1 and 2 cc
of 0.2% Nitrofurazon cream topically was applied to the group 2, daily. The Group 3 only
received flap surgery (control group). Seven days later, all subjects were euthanatized
and necrosis rate in their flaps was calculated and compared to each other. Results.
The necrosis rate was
calculated as 20.25% ± 1.59% in Group 1, 32.05% ± 2.23% in the Group 2
and 37.33% ± 4.12% in the Group 3. It was found that
necrosis rate in the Group 1 was statistically significantly less than Groups 2
and 3 (p < 0.001) and that
difference in necrosis rate between Group 2 and Group 3 was not statistically
significant (p > 0.05). Conclusion.
Necrosis of skin flaps was reduced through topical application of A. purpurea extract. 

 

Keywords

Arnebia purpurea, skin flaps, necrosis, naphthoquinones, plant extracts

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