The relationship between atrial natriuretic peptide and microvascular complications of diabetes

Year 2019, Volume: 5 Issue: 1, 14 - 19, 04.01.2019

Pınar Karakaya , Bahar Özdemir Meral Mert , Hakan Koçoğlu , Abdulbaki Kumbasar

https://doi.org/10.18621/eurj.410990

Abstract

Objective: In this study, we aimed to determine the relationship between the atrial
natriuretic peptide and microvascular complications of diabetes.

Methods: Sixty patients with type 2 diabetes mellitus were enrolled into the study.
Patients with a chronic disease other than diabetes mellitus were excluded from
the study. The body-mass index, waist circumference, and hip circumference were
measured and blood samples for routine biochemical tests were taken after at
least 12 hours fasting. The microvascular complications of the patients were
evaluated.

Results: Thirty-two of the patients had microvascular complications
whereas 28 of them did not. Age, body mass index, waist and hip circumference,
and atrial natriuretic peptide levels were significantly higher in the group
with microvascular complications than those without complications. There was no
significant difference in parameters like; waist-hip ratio, blood glucose,
HbA1c, fasting insulin, fasting HOMA, sodium, potassium, magnesium, calcium and
lipid levels between the two groups. When the relationship between atrial
natriuretic peptide and obesity, retinopathy, neuropathy, nephropathy, duration
of diabetes, HbA1c, and sex are evaluated separately, the only significant
parameters related to atrial natriuretic peptide were the body-mass index,
waist circumference, hip circumference measurements, and neuropathy.

Conclusions: Positive correlations between serum atrial natriuretic peptide levels and
body-mass index, waist circumference, and hip circumference measurements were
determined. Also, serum atrial natriuretic peptide levels were significantly
higher in patients with obesity or neuropathy than those without obesity or
neuropathy. 

Keywords

Atrial natriuretic peptide, diabetes mellitus, microvascular complications

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