The association between lipid profile and bone mineral density in subjects with ankylosing spondylitis

Year 2019, Volume: 5 Issue: 2, 355 - 360, 04.03.2019

Betül Sargın , Gülcan Gürer Hakan Öztürk

https://doi.org/10.18621/eurj.359518

Abstract

Objective: This study aims to investigate the relationship between serum
lipids and bone mineral density in ankylosing spondylitis patients.

Methods: A total of 94 ankylosing spondylitis patients fulfilling the
1984 Modified New York Criteria who had serum lipid levels and bone mineral
density scores in medical records were included in this study. These patients
treated with nonsteroid antiinflammatory drugs. Their files were examined in
detail. Later demographic and laboratory features were recorded to the research
form. Dual-energy X-ray absorptiometry was used to assess bone mineral density
in two bone sites of femur (neck, intertrochanteric zone and trochanter) and
spinal lumbar vertebras (Lumbar 1-Lumbar 4).

Results: Significant and positive correlation was found between high
density lipoprotein and femoral neck bone mineral density (r = 0.356, p =
0.021) in osteopenic group and in osteoporotic group (r = 0.005, p =
0.040).

Conclusion: According to our study significant and positive correlations
are found between high density lipoprotein and femoral neck bone mineral density
in osteopenic and osteoporotic group. However, we believe that more studies are
needed about this research. 

Keywords

Ankylosing spondylitis, lipid profile, bone mineral density

References

• [1] Reveille JD, Weisman MH. The epidemiology of back pain, axial spondyloarthritis and HLA-B27 in the United States. Am J Med Sci 2013;345:431-6.
• [2] Karberg K, Zochling J, Sieper J, Felsenberg D, Braun J. Bone loss is detected more frequently in patients with ankylosing spondylitis with syndesmophytes. J Rheumatol 2005;32:1290-8.
• [3] Singh HJ, Nimarpreet K, Ashima, Das S, Kumar A, Prakash S. Study of bone mineral density in patients with ank ankylosing spondylitis. J Clin Diagn Res 2013;7:2832-5.
• [4] Heslinga SC, Peters MJ, Ter Wee MM, van der Horst-Bruinsma IE, van Sijl AM, Smulders YM, et al. Reduction of inflammation drives lipid changes in ankylosing spondylitis. J Rheumatol 2015;42:1842-5.
• [5] Sabour H, Norouzi Javidan A, Latifi S, Hadian MR, Emami Razavi SH, Shidfar F, et al. Is lipid profile associated with bone mineral density and bone formation in subjects with spinal cord injury? J Osteoporos 2014;2014:695014.
• [6] Garg MK, Marwaha RK, Tandon N, Bhadra K, Mahalle N. Relationship of lipid parameters with bone mineral density in Indian population. Indian J Endocrinol Metab 2014;18:325-32.
• [7] Poiana C, Radoi V, Carsote M, Bilezikian JP. New clues that may link osteoporosis to the circulating lipid profile. Bone Res 2013;25:260-6.
• [8] Fan B, Lu Y, Genant H, Fuerst T, Shepherd J. Does standardized BMD still remove differences between Hologic and GE-Lunar state-of-the-art DXA systems? Osteoporos Int 2010;21:227-36.
• [9] Makovey J, Chen JS, Hayward C, Williams FM, Sambrook PN. Association between serum cholesterol and bone mineral density. Bone. 2009;44:208-13.
• [10] Orozco P. Atherogenic lipid profile and elevated lipoprotein(a) are associated with lower bone mineral density in early postmenopausal overweight women. Eur J Epidemiol 2004;19:1105-12.
• [11] Tankó LB, Bagger YZ, Nielsen SB, Christiansen C. Does serum cholesterol contribute to vertebral bone loss in postmenopausal women? Bone 2003;32:8-14.
• [12] Uyama O, Yoshimoto Y, Yamamoto Y, Kawai A. Bone changes and carotid atherosclerosis in postmenopausal women. Stroke 1997;28:1730-32.
• [13] Samelson EJ, Cupples LA, Hannan MT, Wilson PW, Williams SA, Vaccarino V, et al. Long-term effects of serum cholesterol on bone mineral density in women and men: the Framingham Osteoporosis Study. Bone 2005;34:557-61.
• [14] Solomon DH, Avorn J, Canning CF, Wang PS. Lipid levels and bone mineral density. Am J Med 2005;118:1414.
• [15] Wu LY, Yang TC, Kuo SW, Hsiao CF, Hung YJ, Hsieh CH, et al. Correlation between bone mineral density and plasma lipids in Taiwan. Endocr Res 2003;29:317-25.
• [16] Franceschi C, Bonafè M, Valensin S, Olivieri F, De Luca M, Ottaviani E, et al. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann N Y Acad Sci 2000;908:244-54.
• [17] Koshiyama H, Ogawa Y, Tanaka K, Tanaka I. The unified hypothesis of interactions among the bone, adipose and vascular systems: 'osteo-lipo-vascular interactions'. Med Hypotheses 2006;66:960-63.