Regenerative effect of platelet-rich fibrin on articular cartilage defects in an experimental rat model

Year 2019, Volume: 5 Issue: 2, 299 - 305, 04.03.2019

Hasan Metineren , Turan Cihan Dülgeroğlu

https://doi.org/10.18621/eurj.373385

Cited By: 3

Abstract

Objectives:
Different materials are currently being used experimentally to accelerate
cartilage healing and to obtain hyaline cartilage. We aimed to investigate the
effect of platelet-rich fibrin on joint cartilage healing.

Methods:
Twenty rats were used in this study. platelet-rich fibrin was obtained from
4 rats, and the remaining 16 rats were randomly divided into two groups (4 and
8 weeks). Both knee joints were prepared, and an osteochondral
defect was created at the femoral condyle in all rats.
platelet-rich fibrin was placed into the osteochondral defect of the right
knee, while the left knee joint was used as a control. Groups were sacrificed
after 4 and 8 weeks, respectively.

Results:
According to the O'Driscoll score, there were no significant differences
between the right and left knee scores in group 4 weeks (p = 0.820). However, the right knee scores were
significantly different than the left knee scores in group 8 weeks (p < 0.001). Defects were completely filled with cartilage tissue
after 8 weeks in the platelet-rich fibrin group.

Conclusions:
Similar to its role in various tissues, platelet-rich
fibrin is an effective biomaterial that enhances the healing of osteochondral
defects. 

Keywords

Articular cartilage, chondral healing, experimental rat model, hyaline cartilage, platelet-rich fibrin

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