Significance of thiol/disulphide homeostasis and ischemia modified albumin levels in chronic obstructive pulmonary disease

Year 2019, Volume: 5 Issue: 2, 250 - 257, 04.03.2019

Oğuz Eroğlu , Nermin Dindar Badem , Ayşe Baccıoğlu , Ertan Cömertpay Salim Neşelioğlu Özcan Erel

https://doi.org/10.18621/eurj.425178

Cited By: 4

Abstract

Objectives: The
severity of inflammation occurring during chronic obstructive pulmonary disease
(COPD) is closely associated with oxidative stress. The aim of this study was
to investigate the diagnostic value of Thiol/disulphide homeostasis (TDH) and
ischemia modified albumin (IMA) levels in evaluating oxidative stress in COPD
patients.

Methods: This
prospective study was performed with COPD patients presenting to the Kırıkkale
University Hospital and with healthy volunteers. Subjects’ demographic data
(age, sex, body mass index, and smoking status), native thiol (NT), total thiol
(TT), disulphide (Ds), IMA levels and Ds/NT, Ds/TT and NT/TT ratios were
recorded. Statistical analysis was performed with SPSS 21.0 software.

Results: One hundred ninety
subjects were enrolled in the study, 141 COPD patients and 49 healthy
volunteers. No difference was determined between the patient and control groups
in terms of age, sex or body mass index. The antioxidant markers; NT and TT
levels and NT/TT ratio were significantly lower in the patient group compared
to the control group (p < 0.001, p < 0.001, and p
< 0.003, respectively). The oxidant markers; IMA levels and Ds/NT and Ds/TT
ratios were significantly higher in the patient group (p = 0.006, p
= 0.003, and p = 0.003, respectively). Significant negative correlation
was determined between antioxidant and oxidant parameters. Sensitivity values
were NT: 87.2%, TT: 83.3%, Ds/NT ratio: 68.1%, Ds/TT ratio: 68.1%, and IMA:
77.8%. Conclusions: TDH was
impaired in favor oxidants in COPD patients. TDH parameters and IMA can be used
to monitor oxidative stress emerging in COPD. 

Keywords

Chronic obstructive pulmonary disease, oxidative stress, thiol/disulphide homeostasis, ischemia modified albumin

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