Research Article
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Year 2019, Volume: 5 Issue: 3, 497 - 501, 04.05.2019
https://doi.org/10.18621/eurj.391401

Abstract

References

  • [1] Karadeniz C, Özdemir R, Demirol M, Katipoğlu N, Yozgat Y, Meşe T, et al. Low iron stores in otherwise healthy children affect electrocardiographic markers of important cardiac events. Pediatr Cardiol 2017;38:909-14.
  • [2] Stoltzfus RJ. Iron deficiency: global prevalence and consequences. Food Nutr Bull 2003;24(4 Suppl):99-103.
  • [3] Ghishan FK, Kiela PR. Vitamins and minerals in inflammatory bowel disease. Gastroenterol Clin N Am 2017;46:797-808.
  • [4] Koduah P, Paul F, Dörr JM. Vitamin D in theprevention, predictionand treatment of neurodegenerative and neuroinflammatory diseases. EPMA J 2017;8:313-25.
  • [5] Tick H. Nutrition and pain. Phys Med Rehabil Clin N Am 2015;26:309-20.
  • [6] Straube S, Moore AR, Derry S, Mc Quay HJ. Vitamin D and chronic pain. Pain 2009;141:10-3.
  • [7] Shipton EA, Shipton EE. Vitamin D and pain: Vitamin D and its role in the etiology and maintenance of chronic pain states and associated comorbidities. Pain Res Treat 2015;2015:904967.
  • [8] Abbasi M, Hashemipour S, Hajmanuchehri F, Kazemifar AM. Is vitamin D deficiency associated with non specific musculoskeletal pain? Glob J Health Sci 2012;5:107-11.
  • [9] Helde-Frankling M, Björkhem-Bergman L. Vitamin D in pain management. Int J Mol Sci 2017;18. pii:E2170.
  • [10] Park MJ, Lee J, Lee JK, Joo SY. Prevalence of vitamin D deficiency in Korean children presenting with nonspecific lower-extremity pain. Yonsei Med J 2015;56:1384-8.
  • [11] Zhang M, Han W, Hu S, Xu H. Methylcobalamin: a potential vitamin of pain killer. Neural Plast 2013;2013:424651.
  • [12] Wu PC, Hsiao HT, Lin YC, Shieh DB, Liu YC. The analgesia efficiency of ultrasmall magnetic iron oxide nanoparticles in mice chronic inflammatory pain model. Nanomedicine 2017;13:1975-81.
  • [13] Chun JH, Kim TH, Han MY, Kim NY, Yoon KL. Analysis of clinical characteristics and causes of chest pain in children and adolescents. Korean J Pediatr 2015;58:440-5.
  • [14] Eslick GD, Jones MP, Talley NJ. Non-cardiac chest pain: prevalence, risk factors, impact and consulting - a population-based study. Aliment Pharmacol Ther 2003;17:1115-24.
  • [15] Friedman KG, Kane DA, Rathod RH, Renaud A, Farias M, Geggel R, et al. Management of pediatric chest pain using a standardized assessment and management plan. Pediatrics 2011;128:239-45.
  • [16] Evangelista JA, Parsons M, Renneburg AK. Chest pain in children: diagnosis through history and physical examination. J Pediatr Health Care 2000;14:3-8.
  • [17] Hvas AM, Nexo E. Diagnosis and treatment of vitamin B12 deficiency--an update. Haematologica 2006;91:1506-12.
  • [18] Munns CF, Shaw N, Kiely M, Specker BL, Thacher TD, Ozono K, et al. Global Consensus Recommendations on Prevention and Management of Nutritional Rickets. J Clin Endocrinol Metab 2016;101:394-415.
  • [19] Zadro J, Shirley D, Ferreira M, Carvalho-Silva AP, Lamb SE, Cooper C, et al. Mapping the association between vitamin D and low back pain: a systematic review and meta-analysis of observational studies. Pain Physician 2017;20:611-40.
  • [20] Heuch I, Heuch I, Hagen K, Mai XM, Langhammer A, Zwart JA. Is there an association between vitamin D status and risk of chronic low back pain? A nested case-control analysis in the Nord-Trøndelag Health Study. BMJ Open 2017;7:e018521.
  • [21] Plotnikoff GA, Quigley JM. Prevalence of severe hypovitaminosis D in patients with persistent, nonspecific musculo skeletal pain. Mayo Clin Proc 2003;78:1463-70.
  • [22] Blagojevic Z, Nikolic V, Kisic-Tepavcevic D, Terzic Supic Z, Kovacevic R, Zivkovic Z, et al. Musculoskeletal pain and vitamin D defciency in children: a pilot follow-up study of vitamin D therapy in musculoskeletal/orthopedic conditions. Acta Chir Orthop Traumatol Cech 2016;83:21-6.
  • [23] Ward KA, Das G, Berry JL, Roberts SA, Rawer R, Adams JE, et al. Vitamin D status and muscle function in post-menarchal adolescent girls. J Clin Endocrinol Metab 2009;94:559-63.
  • [24] Cayir A, Turan MI, Tan H. Effect of Vitamin D therapy in addition to amitriptyline on migraine attacks in pediatric patients. Braz J Med Biol Res. 2014;47:349-54.
  • [25] Lawrence DW, Sharma B. A review of the neuroprotective role of vitamin D in traumatic brain injury with implications supplementation post-concussion. Brain Inj 2016;30:960-8.
  • [26] Massin MM, Bourguignont A, Coremans C, Comté L, Lepage P, Gérard P. Chest pain in pediatric patients presenting to an emergency department or to a cardiac clinic. Clin Pediatr (Phila) 2004;43:231-8.
  • [27] Hambrook JT, Kimball TR, Khoury P, Cnota J. Disparities exist in the Emergency Department evaluation of pediatric chest pain. Congenit Heart Dis 2010;5:285-91.
  • [28] Qamar S, Akbani S, Shamim S, Khan G. Vitamin D levels in children with growing pains. J Coll Physicians Surg Pak 2011;21:284-7.

Could there be any relationship between nutritional deficiencies and idiopathic chest pain in children?

Year 2019, Volume: 5 Issue: 3, 497 - 501, 04.05.2019
https://doi.org/10.18621/eurj.391401

Abstract

Objectives: Chest pain in childhood is a frequent cause of referral to pediatric
cardiology departments although cardiac etiology is very rare. Etiology is
usually unidentified and named as ‘idiopatic chest pain’. It is also well known
fact that chronic pain is associated with insuffiency of some nutritional
factors even in childhood. Our aim was to investigate if there is a
relationship between nutritional defiencies with idiopathic chest pain in
children.

Methods: We retrospectively reviewed 364 patients who were
referred pediatric cardiology department in one year period due to experienced
chest pain more than one time. Among these patients, a total of 109 patients
who had complete blood count, serum ferritin, vitamin B 12 and 25-(OH) vitamin
D levels in pediatric outpatient clinics before and the etiology was still unidentified
after a detailed cardiac and other examinations formed the study group. Age and
sex matched 59 healthy children without chest pain formed the control group.
All participants had been evaluated with a detailed physical examination and
patients in chest pain group also had an electrocardiographic ve
echocardiographic evaluation.

Results: Vitamin B12 and Vitamin D
levels were lower in noncardiac chest pain group while there was no difference
between groups in term of ferritin levels and complete blood count parameters.
These difference is statistically significant particularly in vitamin D levels.

Conclusions:
Our results showed that low Vitamin D levels is associated with chronic chest
pain in children. The present study provide the necessity of evaluating
nutritional parameters in  children with
noncardiac chest pain. 

References

  • [1] Karadeniz C, Özdemir R, Demirol M, Katipoğlu N, Yozgat Y, Meşe T, et al. Low iron stores in otherwise healthy children affect electrocardiographic markers of important cardiac events. Pediatr Cardiol 2017;38:909-14.
  • [2] Stoltzfus RJ. Iron deficiency: global prevalence and consequences. Food Nutr Bull 2003;24(4 Suppl):99-103.
  • [3] Ghishan FK, Kiela PR. Vitamins and minerals in inflammatory bowel disease. Gastroenterol Clin N Am 2017;46:797-808.
  • [4] Koduah P, Paul F, Dörr JM. Vitamin D in theprevention, predictionand treatment of neurodegenerative and neuroinflammatory diseases. EPMA J 2017;8:313-25.
  • [5] Tick H. Nutrition and pain. Phys Med Rehabil Clin N Am 2015;26:309-20.
  • [6] Straube S, Moore AR, Derry S, Mc Quay HJ. Vitamin D and chronic pain. Pain 2009;141:10-3.
  • [7] Shipton EA, Shipton EE. Vitamin D and pain: Vitamin D and its role in the etiology and maintenance of chronic pain states and associated comorbidities. Pain Res Treat 2015;2015:904967.
  • [8] Abbasi M, Hashemipour S, Hajmanuchehri F, Kazemifar AM. Is vitamin D deficiency associated with non specific musculoskeletal pain? Glob J Health Sci 2012;5:107-11.
  • [9] Helde-Frankling M, Björkhem-Bergman L. Vitamin D in pain management. Int J Mol Sci 2017;18. pii:E2170.
  • [10] Park MJ, Lee J, Lee JK, Joo SY. Prevalence of vitamin D deficiency in Korean children presenting with nonspecific lower-extremity pain. Yonsei Med J 2015;56:1384-8.
  • [11] Zhang M, Han W, Hu S, Xu H. Methylcobalamin: a potential vitamin of pain killer. Neural Plast 2013;2013:424651.
  • [12] Wu PC, Hsiao HT, Lin YC, Shieh DB, Liu YC. The analgesia efficiency of ultrasmall magnetic iron oxide nanoparticles in mice chronic inflammatory pain model. Nanomedicine 2017;13:1975-81.
  • [13] Chun JH, Kim TH, Han MY, Kim NY, Yoon KL. Analysis of clinical characteristics and causes of chest pain in children and adolescents. Korean J Pediatr 2015;58:440-5.
  • [14] Eslick GD, Jones MP, Talley NJ. Non-cardiac chest pain: prevalence, risk factors, impact and consulting - a population-based study. Aliment Pharmacol Ther 2003;17:1115-24.
  • [15] Friedman KG, Kane DA, Rathod RH, Renaud A, Farias M, Geggel R, et al. Management of pediatric chest pain using a standardized assessment and management plan. Pediatrics 2011;128:239-45.
  • [16] Evangelista JA, Parsons M, Renneburg AK. Chest pain in children: diagnosis through history and physical examination. J Pediatr Health Care 2000;14:3-8.
  • [17] Hvas AM, Nexo E. Diagnosis and treatment of vitamin B12 deficiency--an update. Haematologica 2006;91:1506-12.
  • [18] Munns CF, Shaw N, Kiely M, Specker BL, Thacher TD, Ozono K, et al. Global Consensus Recommendations on Prevention and Management of Nutritional Rickets. J Clin Endocrinol Metab 2016;101:394-415.
  • [19] Zadro J, Shirley D, Ferreira M, Carvalho-Silva AP, Lamb SE, Cooper C, et al. Mapping the association between vitamin D and low back pain: a systematic review and meta-analysis of observational studies. Pain Physician 2017;20:611-40.
  • [20] Heuch I, Heuch I, Hagen K, Mai XM, Langhammer A, Zwart JA. Is there an association between vitamin D status and risk of chronic low back pain? A nested case-control analysis in the Nord-Trøndelag Health Study. BMJ Open 2017;7:e018521.
  • [21] Plotnikoff GA, Quigley JM. Prevalence of severe hypovitaminosis D in patients with persistent, nonspecific musculo skeletal pain. Mayo Clin Proc 2003;78:1463-70.
  • [22] Blagojevic Z, Nikolic V, Kisic-Tepavcevic D, Terzic Supic Z, Kovacevic R, Zivkovic Z, et al. Musculoskeletal pain and vitamin D defciency in children: a pilot follow-up study of vitamin D therapy in musculoskeletal/orthopedic conditions. Acta Chir Orthop Traumatol Cech 2016;83:21-6.
  • [23] Ward KA, Das G, Berry JL, Roberts SA, Rawer R, Adams JE, et al. Vitamin D status and muscle function in post-menarchal adolescent girls. J Clin Endocrinol Metab 2009;94:559-63.
  • [24] Cayir A, Turan MI, Tan H. Effect of Vitamin D therapy in addition to amitriptyline on migraine attacks in pediatric patients. Braz J Med Biol Res. 2014;47:349-54.
  • [25] Lawrence DW, Sharma B. A review of the neuroprotective role of vitamin D in traumatic brain injury with implications supplementation post-concussion. Brain Inj 2016;30:960-8.
  • [26] Massin MM, Bourguignont A, Coremans C, Comté L, Lepage P, Gérard P. Chest pain in pediatric patients presenting to an emergency department or to a cardiac clinic. Clin Pediatr (Phila) 2004;43:231-8.
  • [27] Hambrook JT, Kimball TR, Khoury P, Cnota J. Disparities exist in the Emergency Department evaluation of pediatric chest pain. Congenit Heart Dis 2010;5:285-91.
  • [28] Qamar S, Akbani S, Shamim S, Khan G. Vitamin D levels in children with growing pains. J Coll Physicians Surg Pak 2011;21:284-7.
There are 28 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Original Articles
Authors

Şeyma Kayalı 0000-0002-5400-2189

Nuran Belder This is me 0000-0001-6058-5037

Dilek Gürlek Gökçebay 0000-0001-8097-3950

Publication Date May 4, 2019
Submission Date February 7, 2018
Acceptance Date June 22, 2018
Published in Issue Year 2019 Volume: 5 Issue: 3

Cite

AMA Kayalı Ş, Belder N, Gürlek Gökçebay D. Could there be any relationship between nutritional deficiencies and idiopathic chest pain in children?. Eur Res J. May 2019;5(3):497-501. doi:10.18621/eurj.391401

e-ISSN: 2149-3189 


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