Hepatitis B seroprevalence in hematological oncology patients

Year 2020, Volume: 6 Issue: 2, 87 - 91, 04.03.2020

Melda Turken , Şükran Köse Ayşe Özkan Acar Cengiz Ceylan , Hazal Albayrak Eren Arkalı

https://doi.org/10.18621/eurj.473241

Cited By: 1

Abstract

Objectives:
Hepatitis
B virus (HBV) infection is still a serious public health problem today. Many
factors such as frequent blood transfusion, hemodialysis, sexual contact,
sterilization in surgical procedures, etc. are involved in the transmission of
hepatitis B virus. In our study, HBV seroprevalence was evaluated
retrospectively in order to provide vaccination of anti-HBs negative patients
and to determine HBV prophylaxis in patients with hematological malignancy.

Methods: A
total of 499 patients were included in the study. HBsAg, anti-HBs, anti-HBc
IgG, anti-HDV, HBV DNA values were measured by ELISA (enzyme-linked
immunosorbent assay, Liason, Diasorin, Italy) with Real-Time PCR (Cobas-Tagman,
Roche Switzerland) and recorded. The obtained datas were evaluated by SPSS for
Windows 15.00 statistical program. A value of p <0.05 was accepted as a
statistical significance value.

Results: HBsAg
positivity was found to be 3.4% (n = 17) in all patients. Appropriate treatment
regimens were started to patients with HBsAg (+). There were 166 (33.3%)
patients with anti-HBs (+). One hundred nineteen (23.8%) patients had anti-HBc
IgG (+), 40 (33.6%) of them were started a prophylactic treatment regimen.
Anti-HBs positivity were reported after vaccination in 48 (16.8%) patients.
Occult hepatitis have not been detected in patients with anti-HBc IgG
positivity.

Conclusions: As
a result of this study, anti-HBs negative patients with hematological
malignancies were vaccinated. Patients and physicians should be informed about
vaccination and hepatitis serology controls of hematological malignancy and
other immunosuppressed patients. Sensitivity in this context should be
increased in terms of prophylactic treatments. 

Keywords

Hepatitis B virüs, seroprevalance, hematological malignancy, oncology

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