Relationship between automated perimetry and Heidelberg retina tomograph, optic coherence tomography and laser polarimetry in moderate to severe glaucomatous eyes

Year 2021, Volume: 7 Issue: 3, 270 - 277, 04.05.2021

Mehmet Emin Aslancı Mehmet Baykara , Emre Güler , Ozgur Bulent Timucin , Sami Yılmaz

https://doi.org/10.18621/eurj.721956

Abstract

Objectives: To determine the correlations between the measurements obtained with Heidelberg retina tomograph III (HRT III), optic coherence tomography (OCT), and laser polarimetry (GDx) with the indices of automated perimetry (AP) in moderate and severe glaucoma patients.

Methods: Forty-nine eyes of 30 patients were included in the current study and were divided into two groups: 23 eyes with moderate and 26 eyes with severe glaucoma defined by Hodapp-Parrish-Anderson grading system. Pearson’s correlation coefficients were used to evaluate the correlation between the indices of AP including mean deviation (MD) and pattern standard deviation (PSD), and structural parameters of the retinal nerve fiber layer (RNFL) and optic disc acquired by using three devices in both groups.

Results: In moderate glaucoma OCT and GDx measurements were not correlated to MD only the exception of inferior RNFL (r = 0.57, p = 0.007 and r = 0.52, p = 0.008, respectively). Mild to moderate correlations were calculated between the structural parameters of HRT III and AP indices. In severe glaucoma, the most correlated measurements were obtained by OCT compared to the other devices. The correlations for MD were more powerful compared to PSD. Parameters based on the study of the RNFL showed stronger correlations than those of the optic nerve head. No devices showed significant correlations in patients with MD less than -12 dB.

Conclusions: OCT measurements showed the best correlations with the AP indices in both moderate and severe glaucoma patients. However, AP still seems to be more effective in the follow-up of glaucoma progression in more advanced glaucomatous damage.

Keywords

automated perimetry, Heidelberg retina tomograph,, laser polarimetry, optic coherence tomography, glaucoma

References

• 1. Boden C, Hoffmann EM, Medeiros FA, Zangwill LM, Weinreb RN, Sample PA. Intereye concordance in locations of visual field defects in primary open-angle glaucoma: diagnostic innovations in glaucoma study. Ophthalmology 2006;113:918-23.
• 2. Garway-Heath DF. Early diagnosis in glaucoma. Prog Brain Res 2008;173:47-57.
• 3. Medeiros FA, Zangwill LM, Bowd C, Weinreb RN. Comparison of the GDx VCC scanning laser polarimeter, HRT II confocal scanning laser ophthalmoscope, and stratus OCT optical coherence tomograph for the detection of glaucoma. Arch Ophthalmol 2004;122:827-37.
• 4. Hoh ST, Greenfield DS, Mistlberger A, Liebmann JM, Ishikawa H, Ritch R. Optical coherence tomography and scanning laser polarimetry in normal, ocular hypertensive, and glaucomatous eyes. Am J Ophthalmol 2000;129:129-35.
• 5. Kerrigan-Baumrind LA, Quigley HA, Pease ME, Kerrigan DF, Mitchell RS. Number of ganglion cells in glaucoma eyes compared with threshold visual field tests in the same persons. Invest Ophthalmol Vis Sci 2000;41:741-8.
• 6. Nomoto H, Matsumoto C, Takada S, Hashimoto S, Arimura E, Okuyama S, et al. Detectability of glaucomatous changes using SAP, FDT, flicker perimetry, and OCT. J Glaucoma 2009;18:165-71.
• 7. Greaney MJ, Hoffman DC, Garway-Heath DF, Nakla M, Coleman AL, Caprioli J. Comparison of optic nerve imaging methods to distinguish normal eyes from those with glaucoma. Invest Ophthalmol Vis Sci 2002;43:140-5.
• 8. Anderson DR, Patella VM, eds. Automated Static Perimetry. 2nd ed. St. Louis: Mosby. 1998.
• 9. Bengtsson B, Heijl A. Evaluation of a new perimetric threshold strategy, SITA, in patients with manifest and suspect glaucoma. Acta Ophthalmol Scand 1998;76:268-72.
• 10. Leung CK, Ye C, Weinreb RN, Cheung CY, Qiu Q, Liu S, et al. Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography a study on diagnostic agreement with Heidelberg Retinal Tomograph. Ophthalmology 2010;117:267-74.
• 11. Jaffe GJ, Caprioli J. Optical coherence tomography to detect and manage retinal disease and glaucoma. Am J Ophthalmol 2004;137:156-69.
• 12. Weinreb RN, Bowd C, Zangwill LM. Scanning laser polarimetry in monkey eyes using variable corneal polarization compensation. J Glaucoma 2002;11:378-84.
• 13. Wollstein G, Schuman JS, Price LL, Aydin A, Stark PC, Hertzmark E, et al. Optical coherence tomography longitudinal evaluation of retinal nerve fiber layer thickness in glaucoma. Arch Ophthalmol 2005;123:464-70.
• 14. Kanamori A, Nakamura M, Escano MF, Seya R, Maeda H, Negi A. Evaluation of the glaucomatous damage on retinal nerve fiber layer thickness measured by optical coherence tomography. Am J Ophthalmol 2003;135:513-20.
• 15. Ojima T, Tanabe T, Hangai M, Yu S, Morishita S, Yoshimura N. Measurement of retinal nerve fiber layer thickness and macular volume for glaucoma detection using optical coherence tomography. Jpn J Ophthalmol 2007;51:197-203.
• 16. Wollstein G, Schuman JS, Price LL, Aydin A, Beaton SA, Stark PC, et al. Optical coherence tomography (OCT) macular and peripapillary retinal nerve fiber layer measurements and automated visual fields. Am J Ophthalmol 2004;138:218-25.
• 17. Brigatti L, Caprioli J. Correlation of visual field with scanning confocal laser optic disc measurements in glaucoma. Arch Ophthalmol 1995;113:1191-4.
• 18. Wollstein G, Garway-Heath DF, Hitchings RA. Identification of early glaucoma cases with the scanning laser ophthalmoscope. Ophthalmology 1998;105:1557-63.
• 19. Reus NJ, Lemij HG. Diagnostic accuracy of the GDx VCC for glaucoma. Ophthalmology 2004;111:1860-5.
• 20. Leung CK, Chong KK, Chan WM, Yiu CK, Tso MY, Woo J, et al. Comparative study of retinal nerve fiber layer measurement by StratusOCT and GDx VCC, II: structure/function regression analysis in glaucoma. Invest Ophthalmol Vis Sci 2005;46:3702-11.
• 21. Zangwill LM, Bowd C, Berry CC, Williams J, Blumenthal EZ, Sanchez-Galeana CA, et al. Discriminating between normal and glaucomatous eyes using the Heidelberg Retina Tomograph, GDx Nerve Fiber Analyzer, and Optical Coherence Tomograph. Arch Ophthalmol 2001;119:985-93.
• 22. DeLeon Ortega JE, Sakata LM, Kakati B, McGwin G Jr, Monheit BE, Arthur SN, et al. Effect of glaucomatous damage on repeatability of confocal scanning laser ophthalmoscope, scanning laser polarimetry, and optical coherence tomography. Invest Ophthalmol Vis Sci 2007;48:1156-63.