Relationship between fibroblast growth factor and arrhythmogenesis in normotensive patients with polycystic kidney disease

Year 2015, Volume: 1 Issue: 3, 106 - 112, 04.11.2015

Kemal Karaagac , Abdulmecit Yildiz , Osman Yontar , Erhan Tenekecioglu , Fahriye Vatansever , Mehmet Demir

https://doi.org/10.18621/eurj.2015.1.3.106

Cited By: 1

Abstract

Objectives. Autosomal dominant polycystic kidney disease (ADPKD) is the most common life-threatening genetic disease. Recent prospective studies showed a powerful and dose dependent association between increasing FGF-23 levels and greater risk of mortality among chronic kidney disease patients. In this study, our aim is to evaluate electrocardiogram derived arrhythmogenesis markers such as Tp-e, Tp-e/QT and Tpe/QTc ratio ADPKD. Methods. Data of 31 patients with ADPKD and age-sex matched 26 healthy were gained for study. Electrocardiogram and echocardiogram measurements, various serum markers were compared between groups. Results. FGF-23 was significantly higher, and eGFR was significantly lower in the ADPKD patients. Myocardial thickness was also higher in ADPKD group. Corrected QT dispersion, Tpe, Tp-e/QT and Tp-e/QTc were also compared between groups. All indicators were significantly worse in ADPKD group. In the correlation analyzes, FGF-23 was significantly correlated with Tp-e, Tp-e/QT and Tp-e/QTc (r=0.388, p=0.003; r=0.472, p<0.0001; r=0.442, p=0.001, respectively). Conclusions. In this occasion, we suggest that FGF-23, which probably accumulates ventricular electrical remodeling, may be helpful for risk stratification in patients with ADPKD when used with other indicators. Myocardial cell de-arrangement and electrical remodelling due to fibrosis are suggested mechanisms for this effect.

Keywords

Polycystic kidney disease, fibroblast growth factor, arrhythmogenesis, Tp-e interval, Tp-e/QT ratio

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