Healing potentials of Marigold flower (Tagetes erecta) on full thickness dermal wound in caprine model
Abstract
Objectives: In the modern days multiple drug resistance has been developed against many microbes due to the random use of existing antimicrobial drugs in the treatment of infectious diseases. This paves the way for reconsidering traditional medicine; hence we have carried out to evaluate the wound healing potentials of Marigold flower (Tagetes erecta) in the surgical wound model in black Bengal goats.
Methods: A total of sixteen surgical wounds were made in eight goats under proper restraint and analgesia. Wounds were topically treated with Marigold flower paste (Group A) and normal saline (Group B, control). Post-treatment information was recorded from day 1 to day 21. Planimetric features such as swelling of the wound area, elevation of suture line, and length of the wound were monitored. Histopathological and in vivo anti-microbial studies were also investigated.
Results: Results revealed that aqueous paste of Tagetes erecta flower modulated inflammation and promoted wound contraction leading to earlier healing than those with saline. Histological findings highlighted the normal cutaneous architecture of the marigold treated wound more than that appeared in the saline-treated wound. The antibacterial study revealed that the aqueous paste of marigold flower was highly effective against Staphylococcus aureus which is the ubiquitous bacterial pathogen both in humans and animals.
Conclusions: These results, thus, demonstrate that the aqueous paste of Tagetes erecta flower possesses wound healing activities and it could be a potential candidate for the treatment of dermal wounds by topical application.
Supporting Institution
N/A
Project Number
N/A
Thanks
We thank Director, Veterinary Teaching Hospital, BAU, Mymensingh for sharing animal Keeping facilities.
References
- 1. Furie B, Furie BC. Mechanisms of thrombus formation. N Engl J Med 2008;359:938-49.
- 2. Işık A, Sayar I, Gülhan B, Fırat D. Fascioliasis: a rare case mimicking cholelithiasis. South Clin Ist Euras 2016;27:145-6.
- 3. Isık A, Fırat D, Peker D, Inal A, Yılmaz I, Celebi F. Breast skin necrosis after methylene blue dye injection: breast image. Sakarya Med J 2018;8:153-6.
- 4. Shirazi MH, Ranjbar R, Eshraghi S, Amin G, Nouri MS, Bazzaz N. Inhibitory effects of sage extract on the growth of enteric bacteria. Pak J Biol Sci 2008;11:487-9.
- 5. Oguwike FN, Onubueze DP, Ughachukwu P. Evaluation of activities of Marigold extract on wound healing of albino wister rat. IOSR-JDMS 2013;8:67-70.
- 6. Priyanka D, Shalini T, Navneet VK. A brief study on marigold (Tagetes species): a review. Int Res J Pharm 2013;4:43-8.
- 7. Tamanna SJ, Shihab MM, Akter MA, Rahman M, Alam MM. Therapeutic potentialities of green tea (Camellia sinensis) and aloe vera (Aloe barbadensis) on Staphylococcus aureus induced septic wound in goats. J Bangladesh Agril Univ 2020;18:105-10.
- 8. Jaman MM, Mishra P, Rahman M, Alam MM. Clinical and laboratory investigation on the recurrence of the umbilical hernia after herniorrhaphy in bovine calves. J Bangladesh Agril Univ 2018;16:464-70.
- 9. Ashraf MB, Akter MA, Saha M, Mishra P, Hoda N, Alam MM. Clinicopathological evaluation on capture myopathy due to chemical immobilization in spotted deer. Turk J Vet Res 2019;3:81-4.
- 10. Alam MM, Islam SA, Mohammed Y, Juyena NS, Hashim MA. Comparative efficacy of two medicinal plant extracts and an antibiotic on wound healing. Pak J Biol Sci 2005;8:740-3.
- 11. Alam MM, Islam SA, Hashim MA, Saha D. A comparison of the effect of medicinal plant extract and antibiotic on wound healing with changes of blood values in Black Bengal goat. J Bangladesh Soc Agric Sci Technol 2007;4:141-4.
- 12. Ghani A. Medicinal plants of Bangladesh: chemical constituents and uses. Asiatic society of Bangladesh, 1998.
- 13. Shetty LJ, Sakr FM, Al-Obaidy K, Patel MJ, Shareef H. A brief review on medicinal plant Tagetes erecta Linn. J Appl Pharm Sci 2015;5(Suppl 3):91-5.
- 14. Clark RA. Fibrin and wound healing. Ann NY Acad Sci 2001;936:355-67.
- 15. Singh N, Thakur R. A Review on pharmacological aspects of Tagetes erecta Linn. PharmaTutor 2019;7:16-24.
Abstract
Project Number
N/A
References
- 1. Furie B, Furie BC. Mechanisms of thrombus formation. N Engl J Med 2008;359:938-49.
- 2. Işık A, Sayar I, Gülhan B, Fırat D. Fascioliasis: a rare case mimicking cholelithiasis. South Clin Ist Euras 2016;27:145-6.
- 3. Isık A, Fırat D, Peker D, Inal A, Yılmaz I, Celebi F. Breast skin necrosis after methylene blue dye injection: breast image. Sakarya Med J 2018;8:153-6.
- 4. Shirazi MH, Ranjbar R, Eshraghi S, Amin G, Nouri MS, Bazzaz N. Inhibitory effects of sage extract on the growth of enteric bacteria. Pak J Biol Sci 2008;11:487-9.
- 5. Oguwike FN, Onubueze DP, Ughachukwu P. Evaluation of activities of Marigold extract on wound healing of albino wister rat. IOSR-JDMS 2013;8:67-70.
- 6. Priyanka D, Shalini T, Navneet VK. A brief study on marigold (Tagetes species): a review. Int Res J Pharm 2013;4:43-8.
- 7. Tamanna SJ, Shihab MM, Akter MA, Rahman M, Alam MM. Therapeutic potentialities of green tea (Camellia sinensis) and aloe vera (Aloe barbadensis) on Staphylococcus aureus induced septic wound in goats. J Bangladesh Agril Univ 2020;18:105-10.
- 8. Jaman MM, Mishra P, Rahman M, Alam MM. Clinical and laboratory investigation on the recurrence of the umbilical hernia after herniorrhaphy in bovine calves. J Bangladesh Agril Univ 2018;16:464-70.
- 9. Ashraf MB, Akter MA, Saha M, Mishra P, Hoda N, Alam MM. Clinicopathological evaluation on capture myopathy due to chemical immobilization in spotted deer. Turk J Vet Res 2019;3:81-4.
- 10. Alam MM, Islam SA, Mohammed Y, Juyena NS, Hashim MA. Comparative efficacy of two medicinal plant extracts and an antibiotic on wound healing. Pak J Biol Sci 2005;8:740-3.
- 11. Alam MM, Islam SA, Hashim MA, Saha D. A comparison of the effect of medicinal plant extract and antibiotic on wound healing with changes of blood values in Black Bengal goat. J Bangladesh Soc Agric Sci Technol 2007;4:141-4.
- 12. Ghani A. Medicinal plants of Bangladesh: chemical constituents and uses. Asiatic society of Bangladesh, 1998.
- 13. Shetty LJ, Sakr FM, Al-Obaidy K, Patel MJ, Shareef H. A brief review on medicinal plant Tagetes erecta Linn. J Appl Pharm Sci 2015;5(Suppl 3):91-5.
- 14. Clark RA. Fibrin and wound healing. Ann NY Acad Sci 2001;936:355-67.
- 15. Singh N, Thakur R. A Review on pharmacological aspects of Tagetes erecta Linn. PharmaTutor 2019;7:16-24.
Details
| Primary Language | English |
|---|---|
| Subjects | Surgery |
| Journal Section | Original Articles |
| Authors | |
| Project Number | N/A |
| Publication Date | July 4, 2021 |
| Submission Date | June 30, 2020 |
| Acceptance Date | November 4, 2020 |
| Published in Issue | Year 2021 Volume: 7 Issue: 4 |
Cited By
