Serum oxidative markers and delta neutrophil index in hyperemesis gravidarum

Year 2024, Volume: 10 Issue: 6, 561 - 567, 04.11.2024

Gamze Yılmaz , Deniz Oluklu , Dilek Şahin , Salim Neşelioğlu , Gamze Gök , Özcan Erel , Hatice Akkaya , Ayşe Seval Özgü Erdinç

https://doi.org/10.18621/eurj.1521624

Abstract

Objectives: To evaluate the relationship between different serum oxidative markers and the delta neutrophil index and hyperemesis gravidarum.

Methods: One hundred pregnant women were enrolled in the study and divided into two groups. Group 1 included 50 women with hyperemesis gravidarum, while Group 2 (control group) included 50 pregnant women similar in age, gestational week, and body mass index. Serum oxidative markers and complete blood count inflammatory markers were compared.

Results: Native thiol and total thiol were significantly lower in the Group 1 when compared with the control group (P=0.029 for native thiol; P=0.035 for total thiol). Moreover, ischemia-modified albumin (IMA) and catalase values were significantly higher in the Group 1 than in the control group (P=0.023 for IMA; P=0.021 for catalase). Index1% shows the disulfide/native thiol percent ratio and means that the Group 1 oxidant load is increased but not statistically significant. Myeloperoxidase, ferroxidase, and the delta neutrophil index did not differ significantly between the two groups (P=0.591, P=0.793, and P=0.52; respectively).

Conclusions: According to our study, contrary to the literature, although there are differences in some values, when evaluated individually hyperemesis gravidarum does not impose an extra burden on maternal oxidant-antioxidant balance.

Keywords

Oxidative hemostasis, hyperemesis gravidarum, delta neutrophil index

Ethical Statement

All participants signed informed written consent before being enrolled in the study. The study was reviewed and approved by the ethics committee of Republic of Turkey Ministry of Health Ankara City Hospital (Ethics approval reference number: E2-22-2647. All procedures were performed according to the Declaration of Helsinki.

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