Effects of propylene glycol in different doses on metabolic parameters in dairy cows

Year 2024, Volume: 35 Issue: 1, 44 - 50, 04.07.2024

Adem Şahan , Başak Hanedan

https://doi.org/10.35864/evmd.1401188

Abstract

In the study, the effects of propylene glycol (PG) drenched in different doses in dairy cows with positive energy balance were evaluated on serum metabolic parameters. Twenty-four Simmental dairy cows in 60-190 days of lactation period with positive energy balance were included to this study. PG was drenched 3 h after morning feeding, at a doses of 300 mL (8 dairy cows) and 500 mL (8 dairy cows), once a day, for 3 days. Eight dairy cows were included for control group. Blood samples were collected once before PG drenching, daily after drenching of PG, and finally on day 4. Serum biochemical parameters were determined. With regard to energy metabolism, glucose concentrations from serum biochemical parameters significantly increased on day 3 in 500 mL PG group compared to control group, and there were not significant changes in BHBA and NEFA concentrations. Decreased urea, increased chloride concentrations were determined with within reference limits. In dairy cows with positive energy balance, 500 mL PG oral drenching had positive effect on energy balance as determined by serum glucose measurements, might not have negative effects on hepatic and renal function, and may cause serum electrolyte changes within reference limits.

Keywords

Dairy cows, propylene glycol, serum metabolic parameters

Project Number

TDK-2021-9002

Süt ineklerinde farklı dozlarda propilen glikolün metabolik parametreler üzerine etkileri

Abstract

Çalışmada pozitif enerji dengesine sahip süt ineklerinde farklı dozlarda propilen glikol (PG) uygulamasının serum metabolik parametreleri üzerine etkileri değerlendirildi. Çalışmaya 60-190 günlük laktasyon döneminde pozitif enerji dengesine sahip 24 adet Simental ırkı süt ineği dahil edildi. PG, sabah yemlemesinden 3 saat sonra, günde bir kez 300 mL (8 süt sığırı) ve 500 mL (8 süt sığırı) dozlarında 3 gün boyunca uygulandı. Kontrol grubu için sekiz süt sığırı dahil edildi. Kan örnekleri PG uygulamasından önce bir kez, PG uygulamasından sonra günlük olarak ve son olarak 4. günde toplandı. Serum biyokimyasal parametreleri belirlendi. Enerji metabolizması ile ilgili olarak, serum biyokimyasal parametrelerinden glikoz yoğunlukları kontrol grubuna kıyasla 500 mL PG grubunda 3. günde önemli ölçüde arttı, BHBA ve NEFA yoğunluklarında ise önemli bir değişiklik olmadı. Üre yoğunluklarında azalma, klorür yoğunluklarında ise referans sınırlar içerisinde artış tespit edildi. Pozitif enerji dengesine sahip süt ineklerinde, 500 mL PG oral içirmenin serum glikoz ölçümleri ile belirlenen enerji dengesi üzerinde olumlu etkisi olduğu, hepatik ve renal fonksiyonlar üzerinde olumsuz etkileri olmayabileceği ve referans sınırlar içinde serum elektrolit değişikliklerine neden olabileceği sonucuna varıldı.

Keywords

Propilen glikol, serum metabolik parametreleri, süt ineği

Ethical Statement

This study was approved by Atatürk University Ethics Committee (13.01.2020/5)

Supporting Institution

This study was funded by Atatürk University Scientific Research Unit (TDK-2021-9002).

Project Number

TDK-2021-9002

Thanks

The authors thank Atatürk University Scientific Research Projects Coordination Unit that funded this study (TDK-2021-9002). In addition, the authors thank Cinisli livestock for the use of the dairy cows and veterinary technical support.

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